Connective tissue diseases: Difference between revisions
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'''Connective tissue diseases''' are infrequently seen by [[pathologist]]s. | '''Connective tissue diseases''', also '''connective tissue disorders''', are infrequently seen by [[pathologist]]s. | ||
They may be very important in the context of [[forensic pathology]], as they may be an explanation for multiple fractures | They may be very important in the context of [[forensic pathology]], as they may be an explanation for multiple fractures, which may be seen in child abuse. | ||
=Specific entities= | |||
==Mixed connective tissue disease== | |||
*Abbreviated ''MCTD''. | |||
===General=== | |||
*A wastebasket diagnosis in [[rheumatology]]. | |||
Serology - classic, non-[[specificity|specific]]: | |||
*Anti-U1-RNP (ribonucleoprotein) +ve,<ref name=pmid20722023>{{Cite journal | last1 = Sato | first1 = T. | last2 = Fujii | first2 = T. | last3 = Yokoyama | first3 = T. | last4 = Fujita | first4 = Y. | last5 = Imura | first5 = Y. | last6 = Yukawa | first6 = N. | last7 = Kawabata | first7 = D. | last8 = Nojima | first8 = T. | last9 = Ohmura | first9 = K. | title = Anti-U1 RNP antibodies in cerebrospinal fluid are associated with central neuropsychiatric manifestations in systemic lupus erythematosus and mixed connective tissue disease. | journal = Arthritis Rheum | volume = 62 | issue = 12 | pages = 3730-40 | month = Dec | year = 2010 | doi = 10.1002/art.27700 | PMID = 20722023 }}</ref> | |||
Usually has some features of:<ref>URL: [http://www.merckmanuals.com/home/bone_joint_and_muscle_disorders/autoimmune_disorders_of_connective_tissue/mixed_connective_tissue_disease_mctd.html http://www.merckmanuals.com/home/bone_joint_and_muscle_disorders/autoimmune_disorders_of_connective_tissue/mixed_connective_tissue_disease_mctd.html]. Accessed on: 18 February 2012.</ref> | |||
*[[Systemic lupus erythematosus]]. | |||
*Systemic sclerosis. | |||
*[[Polymyositis]]. | |||
==Ehlers-Danlos syndrome== | ==Ehlers-Danlos syndrome== | ||
{{Main|Ehlers-Danlos syndrome}} | {{Main|Ehlers-Danlos syndrome}} | ||
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==References== | ==References== | ||
{{Reflist| | {{Reflist|2}} | ||
[[Category:Weird stuff]] | [[Category:Weird stuff]] | ||