Difference between revisions of "Zollinger-Ellison syndrome"
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'''Zollinger-Ellison syndrome''', abbreviated '''ZES''', is the triad of pancreatic gastrinoma, peptic ulcers of the small bowel and gastric hypersecretion.<ref name=pmid13259432>{{cite journal |author=Zollinger RM, Ellison EH |title=Primary peptic ulcerations of the jejunum associated with islet cell tumors of the pancreas |journal=Ann. Surg. |volume=142 |issue=4 |pages=709–23; discussion, 724–8 |year=1955 |pmid=13259432|doi=10.1097/00000658-195510000-00015 |PMC = 1465210 |URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1465210/?page=1 }}</ref> | '''Zollinger-Ellison syndrome''', abbreviated '''ZES''', is the triad of pancreatic gastrinoma, peptic ulcers of the small bowel and gastric hypersecretion.<ref name=pmid13259432>{{cite journal |author=Zollinger RM, Ellison EH |title=Primary peptic ulcerations of the jejunum associated with islet cell tumors of the pancreas |journal=Ann. Surg. |volume=142 |issue=4 |pages=709–23; discussion, 724–8 |year=1955 |pmid=13259432|doi=10.1097/00000658-195510000-00015 |PMC = 1465210 |URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1465210/?page=1 }}</ref> | ||
==General== | |||
*May be part of [[MEN 1|multiple endocrine neoplasia 1]]. | |||
Clinical: | |||
*Abdominal pain. | |||
*Diarrhea. | |||
Laboratory: | |||
*Serum gastrin often elevated - though not usually not very high.<ref name=pmid17108778>{{Cite journal | last1 = Berna | first1 = MJ. | last2 = Hoffmann | first2 = KM. | last3 = Serrano | first3 = J. | last4 = Gibril | first4 = F. | last5 = Jensen | first5 = RT. | title = Serum gastrin in Zollinger-Ellison syndrome: I. Prospective study of fasting serum gastrin in 309 patients from the National Institutes of Health and comparison with 2229 cases from the literature. | journal = Medicine (Baltimore) | volume = 85 | issue = 6 | pages = 295-330 | month = Nov | year = 2006 | doi = 10.1097/01.md.0000236956.74128.76 | PMID = 17108778 }}</ref> | |||
**Gastrin may be elevated due to chronic proton pump inhibitor (PPI) use - 35+/-20 pg/ml (normal) versus 170+/-135 pg/ml (chronic PPI use).<ref name=pmid22460728>{{Cite journal | last1 = Raines | first1 = D. | last2 = Chester | first2 = M. | last3 = Diebold | first3 = AE. | last4 = Mamikunian | first4 = P. | last5 = Anthony | first5 = CT. | last6 = Mamikunian | first6 = G. | last7 = Woltering | first7 = EA. | title = A prospective evaluation of the effect of chronic proton pump inhibitor use on plasma biomarker levels in humans. | journal = Pancreas | volume = 41 | issue = 4 | pages = 508-11 | month = May | year = 2012 | doi = 10.1097/MPA.0b013e318243a0b6 | PMID = 22460728 }}</ref> | |||
==Microscopic== | |||
===Pancreas=== | |||
:See: ''[[Pancreatic neuroendocrine tumour]]''. | |||
===Stomach=== | |||
*G-cell hyperplasia. | |||
DDx: | |||
*Pseudo-Zollinger-Ellison syndrome.<ref name=pmid10833904>{{Cite journal | last1 = Tomaszewska | first1 = R. | last2 = Kedra | first2 = B. | last3 = Stachura | first3 = J. | title = Hypertrophic gastritis, primary diffuse G-cell hyperplasia and pancreatic metaplasia of the gastric mucosa (pseudo-Zollinger-Ellison syndrome)--case report. | journal = Pol J Pathol | volume = 51 | issue = 1 | pages = 51-4 | month = | year = 2000 | doi = | PMID = 10833904 }} | |||
</ref> | |||
==See also== | ==See also== | ||
Latest revision as of 12:33, 14 May 2013
Zollinger-Ellison syndrome, abbreviated ZES, is the triad of pancreatic gastrinoma, peptic ulcers of the small bowel and gastric hypersecretion.[1]
General
- May be part of multiple endocrine neoplasia 1.
Clinical:
- Abdominal pain.
- Diarrhea.
Laboratory:
- Serum gastrin often elevated - though not usually not very high.[2]
- Gastrin may be elevated due to chronic proton pump inhibitor (PPI) use - 35+/-20 pg/ml (normal) versus 170+/-135 pg/ml (chronic PPI use).[3]
Microscopic
Pancreas
Stomach
- G-cell hyperplasia.
DDx:
- Pseudo-Zollinger-Ellison syndrome.[4]
See also
References
- ↑ Zollinger RM, Ellison EH (1955). "Primary peptic ulcerations of the jejunum associated with islet cell tumors of the pancreas". Ann. Surg. 142 (4): 709–23; discussion, 724–8. doi:10.1097/00000658-195510000-00015. PMC 1465210. PMID 13259432. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1465210/.
- ↑ Berna, MJ.; Hoffmann, KM.; Serrano, J.; Gibril, F.; Jensen, RT. (Nov 2006). "Serum gastrin in Zollinger-Ellison syndrome: I. Prospective study of fasting serum gastrin in 309 patients from the National Institutes of Health and comparison with 2229 cases from the literature.". Medicine (Baltimore) 85 (6): 295-330. doi:10.1097/01.md.0000236956.74128.76. PMID 17108778.
- ↑ Raines, D.; Chester, M.; Diebold, AE.; Mamikunian, P.; Anthony, CT.; Mamikunian, G.; Woltering, EA. (May 2012). "A prospective evaluation of the effect of chronic proton pump inhibitor use on plasma biomarker levels in humans.". Pancreas 41 (4): 508-11. doi:10.1097/MPA.0b013e318243a0b6. PMID 22460728.
- ↑ Tomaszewska, R.; Kedra, B.; Stachura, J. (2000). "Hypertrophic gastritis, primary diffuse G-cell hyperplasia and pancreatic metaplasia of the gastric mucosa (pseudo-Zollinger-Ellison syndrome)--case report.". Pol J Pathol 51 (1): 51-4. PMID 10833904.