Medullary breast carcinoma: Difference between revisions
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = | |||
| Width = | |||
| Caption = | |||
| Synonyms = | |||
| Micro = all required: (1) lesion has well-circumscribed border, (2) syncytial growth pattern, (3) lymphocytic infiltrate, (4) high nuclear grade (as per Nottingham grading system), (5) no tubule formation | |||
| Subtypes = | |||
| LMDDx = [[Invasive ductal carcinoma of the breast|Invasive ductal carcinoma]] with medullary features | |||
| Stains = | |||
| IHC = ER -ve, PR -ve, HER2 -ve | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = [[breast grossing]] | |||
| Staging = [[breast cancer staging]] | |||
| Site = [[breast]] - see ''[[invasive breast cancer]]'' | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = uncommon | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = better than NST | |||
| Other = | |||
| ClinDDx = | |||
| Tx = | |||
}} | |||
'''Medullary breast carcinoma''' is an uncommon form of [[invasive breast carcinoma]]. | |||
It is also known as '''medullary carcinoma of the breast'''. | |||
==General== | |||
*Uncommon breast cancer subtype. | |||
*Some pathologists very rarely make the diagnosis.{{fact}} | |||
Epidemiology: | |||
*Thought to have a better prognosis that no special type (NST). | |||
*May be associated with a [[BRCA1]] mutation. | |||
==Gross== | |||
*Well-circumscribed border.<ref name=pmid21071383>{{Cite journal | last1 = Yoo | first1 = JL. | last2 = Woo | first2 = OH. | last3 = Kim | first3 = YK. | last4 = Cho | first4 = KR. | last5 = Yong | first5 = HS. | last6 = Seo | first6 = BK. | last7 = Kim | first7 = A. | last8 = Kang | first8 = EY. | title = Can MR Imaging contribute in characterizing well-circumscribed breast carcinomas? | journal = Radiographics | volume = 30 | issue = 6 | pages = 1689-702 | month = Oct | year = 2010 | doi = 10.1148/rg.306105511 | PMID = 21071383 }}</ref> | |||
Aside - malignant well-circumscribed breast masses - radiologic DDx:<ref name=pmid21071383/> | |||
*Medullary breast carcinoma. | |||
*[[Mucinous breast carcinoma]]. | |||
*[[Phyllodes tumour|Malignant phyllodes tumour]]. | |||
*[[Invasive papillary carcinoma of the breast]]. | |||
==Microscopic== | |||
Features: | |||
#Lesion has well-circumscribed border. | |||
#Syncytial growth pattern = clumps of cells with poorly defined cell borders. | |||
#Lymphocytic infiltrate. | |||
#High nuclear grade (as per Nottingham grading system). | |||
#No tubule formation. | |||
DDx: | |||
*[[Invasive ductal carcinoma of the breast|Invasive ductal carcinoma]] with medullary features. | |||
==Images== | |||
<gallery> | |||
Image:Breast MedullaryCarcinoma (2) PA.JPG|Breast - Medullary Carcinoma - low power (SKB) | |||
Image:Breast MedullaryCarcinoma TripleNegative LP PA.JPG|Breast - Medullary Carcinoma - medium power (SKB) | |||
Image:Breast MedullaryCarcinoma TripleNegative HP PA.JPG|Breast - Medullary Carcinoma - high power (SKB) | |||
</gallery> | |||
==IHC== | |||
Features - typical:<ref>{{Cite journal | last1 = Matkovic | first1 = B. | last2 = Juretic | first2 = A. | last3 = Separovic | first3 = V. | last4 = Novosel | first4 = I. | last5 = Separovic | first5 = R. | last6 = Gamulin | first6 = M. | last7 = Kruslin | first7 = B. | title = Immunohistochemical analysis of ER, PR, HER-2, CK 5/6, p63 and EGFR antigen expression in medullary breast cancer. | journal = Tumori | volume = 94 | issue = 6 | pages = 838-44 | month = | year = | doi = | PMID = 19267102 }}</ref> | |||
*ER -ve. | |||
*PR -ve. | |||
*HER2 -ve. | |||
==See also== | |||
*[[Invasive breast carcinoma]]. | |||
*[[Medullary carcinoma]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Invasive breast cancer]] | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||