Difference between revisions of "Scleroderma"

Latest revision as of 16:32, 5 August 2015

Scleroderma is a disease that keeps rheumatologists busy.

Clinical:

Anti-centromere antibody (ACA) +ve.
- Common in limited systemic scleroderma, AKA CREST syndrome.
Scl-70 (topoisomerase I) +ve.
- Common in diffuse scleroderma.

CREST syndrome:

↑ Jones, NF.; Imbriglia, JE.; Steen, VD.; Medsger, TA. (May 1987). "Surgery for scleroderma of the hand.". J Hand Surg Am 12 (3): 391-400. PMID 3584887.

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 ==General==
-*Anti-centromere antibody +ve.
+Clinical:
-**Common in ''limited systemic scleroderma'', [[AKA]] CREST Syndrome.
+*Anti-centromere antibody (ACA) +ve.
+**Common in ''limited systemic scleroderma'', [[AKA]] CREST syndrome.
+*Scl-70 (topoisomerase I) +ve.
+**Common in ''diffuse scleroderma''.
+CREST syndrome:
+*Calcinosis.
+*Raynaud's phenomenon.
+*[[esophagus|Esophageal]] dysmotility.
+*Sclerodactyly.
+*Telangiectasia.
 ==Associated pathology==
 *[[Scleroderma panniculitis]].
+*Scleroderma renal crisis - see ''[[thrombotic microangiopathy]]''.
+*Digit ischemia - may require [[finger amputation]].<ref>{{Cite journal  | last1 = Jones | first1 = NF. | last2 = Imbriglia | first2 = JE. | last3 = Steen | first3 = VD. | last4 = Medsger | first4 = TA. | title = Surgery for scleroderma of the hand. | journal = J Hand Surg Am | volume = 12 | issue = 3 | pages = 391-400 | month = May | year = 1987 | doi =  | PMID = 3584887 }}</ref>
 ==See also==
 *[[Basics]].
+*[[Systemic lupus erythematosus]].
+==References==
+{{Reflist|1}}
 [[Category:Clinical]]
+[[Category:Diagnosis]]