Difference between revisions of "Spindle cell lesions"
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(→Malignant fibrous histiocytoma: beta-catenin) |
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==Malignant fibrous histiocytoma== | ==Malignant fibrous histiocytoma== | ||
Work-up (MSH): | Work-up (MSH): | ||
*CD34 - GIST, angiosarcoma. | *CD34 - GIST, angiosarcoma, solitary fibrous tumour/hemangiopericytoma. | ||
*S100 - neural marker, sensitive for malignant melanoma. | *S100 - neural marker, sensitive for malignant melanoma. | ||
*Desmin - smooth muscle. | *Desmin - smooth muscle. | ||
Revision as of 18:42, 6 July 2010
Spindle cell lesions are seen frequent enough that one ought to have a solid approach to 'em.
General DDx
Spindle cells should make think:
- Nerve.
- Muscle.
- Smooth.
- Skeletal.
- Other.
Malignant fibrous histiocytoma
Work-up (MSH):
- CD34 - GIST, angiosarcoma, solitary fibrous tumour/hemangiopericytoma.
- S100 - neural marker, sensitive for malignant melanoma.
- Desmin - smooth muscle.
- MIB-1 - proliferation.
- CD99 - small round cell tumours, considered "slutty", i.e. non-specific, by Dr. Fletcher; useful if membranous stain pattern = Ewing sarcoma/PNET.
- Bcl-2.
- PGP 9.5.
- SMMS - smooth muscle.
- Caldesmon - muscle.
- PDGFR - GIST.
- DOG-1 - GIST (membranous, cytoplasmic),[1] normal pancreas (islets),[1] associated with BRCA1.
Others:
- Beta-catenin - a small subset of soft tissue lesions:
- Desmoidtype fibromatosis (~70%), solitary fibrous tumour & endometrial stromal sarcoma (~40%), synovial sarcoma (~30%).[2]
See also
References
- ↑ 1.0 1.1 Ardeleanu C, Arsene D, Hinescu M, et al. (October 2009). "Pancreatic expression of DOG1: a novel gastrointestinal stromal tumor (GIST) biomarker". Appl. Immunohistochem. Mol. Morphol. 17 (5): 413–8. doi:10.1097/PAI.0b013e31819e4dc5. PMID 19417627.
- ↑ Ng TL, Gown AM, Barry TS, et al. (January 2005). "Nuclear beta-catenin in mesenchymal tumors". Mod. Pathol. 18 (1): 68–74. doi:10.1038/modpathol.3800272. PMID 15375433.