Difference between revisions of "NUT carcinoma"
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Clinical: | Clinical: | ||
*Usually midline - as the name of the tumour suggests. | *Usually midline - as the name of the tumour suggests. | ||
*[[Head and neck pathology|Head, neck]] and mediastinum.<ref name=pmid18552174>{{Cite journal | last1 = French | first1 = CA. | title = Demystified molecular pathology of NUT midline carcinomas. | journal = J Clin Pathol | volume = 63 | issue = 6 | pages = 492-6 | month = Jun | year = 2010 | doi = 10.1136/jcp.2007.052902 | PMID = 18552174 }}</ref> | |||
*Poor prognosis. | |||
==Microscopic== | ==Microscopic== | ||
Features:<ref name=pmid20951314>{{Cite journal | last1 = French | first1 = CA. | title = NUT midline carcinoma. | journal = Cancer Genet Cytogenet | volume = 203 | issue = 1 | pages = 16-20 | month = Nov | year = 2010 | doi = 10.1016/j.cancergencyto.2010.06.007 | PMID = 20951314 }} | Features:<ref name=pmid20951314>{{Cite journal | last1 = French | first1 = CA. | title = NUT midline carcinoma. | journal = Cancer Genet Cytogenet | volume = 203 | issue = 1 | pages = 16-20 | month = Nov | year = 2010 | doi = 10.1016/j.cancergencyto.2010.06.007 | PMID = 20951314 }}</ref><ref name=pmid18552174>{{Cite journal | last1 = French | first1 = CA. | title = Demystified molecular pathology of NUT midline carcinomas. | journal = J Clin Pathol | volume = 63 | issue = 6 | pages = 492-6 | month = Jun | year = 2010 | doi = 10.1136/jcp.2007.052902 | PMID = 18552174 }}</ref> | ||
</ref> | |||
*Poorly differentiated carcinoma. | *Poorly differentiated carcinoma. | ||
**Cohesive malignant cells. | |||
*Islands of well-differentiated squamous epithelium - '''key feature'''. | *Islands of well-differentiated squamous epithelium - '''key feature'''. | ||
DDx: | |||
*[[Carcinoma ex pleomorphic adenoma]]. | |||
*Poorly differentiated carcinoma. | |||
==Molecular== | ==Molecular== | ||
*Rearrangement of the ''NUT'' gene.<ref name=pmid20951314/> | *Rearrangement of the ''NUT'' gene.<ref name=pmid20951314/> | ||
**Most common: ''BRD | **Most common: t(15;19)(q14;p13) ''BRD/NUT''.<ref name=pmid18552174>{{Cite journal | last1 = French | first1 = CA. | title = Demystified molecular pathology of NUT midline carcinomas. | journal = J Clin Pathol | volume = 63 | issue = 6 | pages = 492-6 | month = Jun | year = 2010 | doi = 10.1136/jcp.2007.052902 | PMID = 18552174 }}</ref><ref>{{OMIM|608749}}</ref> | ||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
[[Category:Weird stuff]] | [[Category:Weird stuff]] | ||
[[Category:Diagnosis]] | |||
Revision as of 19:57, 15 November 2011
NUT midline carcinoma is a super rare tumour.
General
- Not specific to any tissue type or organ.[1]
- Defined by mutation in NUT gene.
- NUT = Nuclear protein in testis.[2]
Clinical:
- Usually midline - as the name of the tumour suggests.
- Head, neck and mediastinum.[3]
- Poor prognosis.
Microscopic
- Poorly differentiated carcinoma.
- Cohesive malignant cells.
- Islands of well-differentiated squamous epithelium - key feature.
DDx:
- Carcinoma ex pleomorphic adenoma.
- Poorly differentiated carcinoma.
Molecular
References
- ↑ 1.0 1.1 1.2 French, CA. (Nov 2010). "NUT midline carcinoma.". Cancer Genet Cytogenet 203 (1): 16-20. doi:10.1016/j.cancergencyto.2010.06.007. PMID 20951314.
- ↑ Online 'Mendelian Inheritance in Man' (OMIM) 608963
- ↑ 3.0 3.1 3.2 French, CA. (Jun 2010). "Demystified molecular pathology of NUT midline carcinomas.". J Clin Pathol 63 (6): 492-6. doi:10.1136/jcp.2007.052902. PMID 18552174.
- ↑ Online 'Mendelian Inheritance in Man' (OMIM) 608749