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Difference between revisions of "Thrombotic microangiopathy"
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Thrombotic microangiopathy (view source)
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'''Thrombotic microangiopathy''' is a group of disorders affecting small blood vessels. ''Microangiopathic'' is a disease affecting small blood vessels.<ref>URL: [http://www.mercksource.com/pp/us/cns/cns_hl_dorlands_split.jsp?pg=/ppdocs/us/common/dorlands/dorland/one/000005089.htm http://www.mercksource.com/pp/us/cns/cns_hl_dorlands_split.jsp?pg=/ppdocs/us/common/dorlands/dorland/one/000005089.htm]. Accessed on: 9 September 2010.</ref> | '''Thrombotic microangiopathy''' is a group of disorders affecting small blood vessels. ''Microangiopathic'' is a disease affecting small blood vessels.<ref>URL: [http://www.mercksource.com/pp/us/cns/cns_hl_dorlands_split.jsp?pg=/ppdocs/us/common/dorlands/dorland/one/000005089.htm http://www.mercksource.com/pp/us/cns/cns_hl_dorlands_split.jsp?pg=/ppdocs/us/common/dorlands/dorland/one/000005089.htm]. Accessed on: 9 September 2010.</ref> | ||
==Differential diagnosis== | |||
The grouping includes:<ref>URL: [http://emedicine.medscape.com/article/779218-overview http://emedicine.medscape.com/article/779218-overview]. Accessed on: 8 November 2010.</ref><ref name=pmid15915311>{{cite journal |author=Mayer SA, Aledort LM |title=Thrombotic microangiopathy: differential diagnosis, pathophysiology and therapeutic strategies |journal=Mt. Sinai J. Med. |volume=72 |issue=3 |pages=166–75 |year=2005 |month=May |pmid=15915311 |doi= |url=}}</ref> | The grouping includes:<ref>URL: [http://emedicine.medscape.com/article/779218-overview http://emedicine.medscape.com/article/779218-overview]. Accessed on: 8 November 2010.</ref><ref name=pmid15915311>{{cite journal |author=Mayer SA, Aledort LM |title=Thrombotic microangiopathy: differential diagnosis, pathophysiology and therapeutic strategies |journal=Mt. Sinai J. Med. |volume=72 |issue=3 |pages=166–75 |year=2005 |month=May |pmid=15915311 |doi= |url=}}</ref> | ||
*[[Hemolytic uremic syndrome]]. | *[[Hemolytic uremic syndrome]]. | ||
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*[[DIC]]. | *[[DIC]]. | ||
*[[APLA]] in [[SLE]]. | *[[APLA]] in [[SLE]]. | ||
*Scleroderma renal crisis. | *[[Scleroderma]] renal crisis. | ||
*HIV associated TTP. | *[[HIV]] associated TTP. | ||
*Chemotherapy. | *Chemotherapy. | ||
*Calcineurin inhibitor toxicity. | *Calcineurin inhibitor toxicity. | ||
Notes: | |||
*The above cannot be differentiated on a histomorphologic basis. | |||
==General== | |||
*Underlying pathology: endothelial cell damage. | |||
==Microscopic== | ==Microscopic== | ||
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Notes: | Notes: | ||
*The last two (#2 and #3) are useful for discrimination from endarteritis.<ref name=Ref_FoRP>{{Ref FoRP|204}}</ref> | *The last two (#2 and #3) are useful for discrimination from endarteritis.<ref name=Ref_FoRP>{{Ref FoRP|204}}</ref> | ||
*Early finding: endothelial cell swelling. | |||
Image: | Image: | ||