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Difference between revisions of "Gallbladder"
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redo refs
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*+/-Foamy macrophages in the lamina propria. | *+/-Foamy macrophages in the lamina propria. | ||
*Inflammatory cells. | *Inflammatory cells. | ||
**[[Neutrophils]] are not essential for the Dx - usually secondary to necrosis/ulceration or infection.<ref> | **[[Neutrophils]] are not essential for the Dx - usually secondary to necrosis/ulceration or infection.<ref name=Ref_DCHH174>{{Ref DCHH|174}}</ref> | ||
==Cholesterolosis== | ==Cholesterolosis== | ||
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*Polyps - significant as they may be adenomatous, i.e. pre-cancerous. | *Polyps - significant as they may be adenomatous, i.e. pre-cancerous. | ||
Flat dysplasia<ref> | Flat dysplasia:<ref name=Ref_DCHH172>{{Ref DCHH|172}}</ref> | ||
*Nuclear changes | *Nuclear changes. | ||
**Incr. [[NC ratio]] | **Incr. [[NC ratio]]. | ||
**Hyperchromasia (essential) | **Hyperchromasia (essential). | ||
**+/-Intestinal metaplasia --> goblet cells. | **+/-Intestinal metaplasia --> goblet cells. | ||
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==Intestinal metaplasia== | ==Intestinal metaplasia== | ||
Definition: | Definition: | ||
*Presence of [[goblet cell]]s -/+ paneth cells<ref>Sternberg DSP4 P.1789</ref> | *Presence of [[goblet cell]]s -/+ paneth cells.<ref>Sternberg DSP4 P.1789</ref> | ||
Significance: | Significance: | ||
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==Antral type metaplasia== | ==Antral type metaplasia== | ||
General | ===General=== | ||
*[[ | *[[AKA]] ''pyloric metaplasia'', ''pseudopyloric metaplasia'', ''mucous gland metaplasia''.<ref>Sternberg DSP4 P.1789</ref> | ||
===Microscopic=== | |||
Features:<ref>Sternberg DSP4 P.1789</ref> | |||
*Cells with... | |||
**Abundant, pale, apical mucin. | **Abundant, pale, apical mucin. | ||
**Small basal nucleus. | **Small basal nucleus. | ||
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===Microscopic=== | ===Microscopic=== | ||
*Usually adenocarcinoma. | *Usually adenocarcinoma. | ||
**Mimics appearance of pancreatic ductal adenocarcinoma-- but less cellular mucin.<ref> | **Mimics appearance of pancreatic ductal adenocarcinoma-- but less cellular mucin.<ref name=Ref_DCHH174>{{Ref DCHH|174}}</ref> | ||
Notes: | Notes: | ||