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Difference between revisions of "Nephrotic syndrome"
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Features:<ref>URL: [http://www.kidneypathology.com/English_version/Focal_segmental_GS.html http://www.kidneypathology.com/English_version/Focal_segmental_GS.html]. Accessed on: 11 February 2011.</ref> | Features:<ref>URL: [http://www.kidneypathology.com/English_version/Focal_segmental_GS.html http://www.kidneypathology.com/English_version/Focal_segmental_GS.html]. Accessed on: 11 February 2011.</ref> | ||
*PAS +ve crescents. | *PAS +ve crescents. | ||
===IF=== | |||
*No immune deposits. | |||
**No IgG. | |||
**No IgA. | |||
Note: | |||
*IgM, C3 - may be focally positive due to trapping. | |||
===EM=== | |||
*Foot process loss. | |||
**Secondary causes tend to have a thinner foot process width. | |||
==Membranous nephropathy== | ==Membranous nephropathy== | ||
*[[AKA]] ''membranous glomerulonephritis''. | |||
*Abbreviated ''MN''. | |||
===General=== | ===General=== | ||
*Presents as nephrotic syndrome. | *Presents as nephrotic syndrome. | ||
*Variable course. | |||
Clinical DDx:<ref>{{Ref Klatt|241}}</ref> | Clinical DDx:<ref>{{Ref Klatt|241}}</ref> | ||
| Line 125: | Line 140: | ||
===Microscopic=== | ===Microscopic=== | ||
Features: | Features: | ||
*Subepithelial immune complex depositions | *Subepithelial immune complex depositions: | ||
**Spikes or pinholes - seen on silver stain. | |||
**+/-Tram-tracking. | |||
***Advanced lesions. | |||
Image: | Image: | ||
*[http://commons.wikimedia.org/wiki/File:Membranous_Nephropathy_Pathology_Diagram.svg MN - schematic (WC)]. | *[http://commons.wikimedia.org/wiki/File:Membranous_Nephropathy_Pathology_Diagram.svg MN - schematic (WC)]. | ||
===IF=== | |||
*Diffuse granular capillary loop - IgG, C3, kappa, lambda. | |||
=See also= | =See also= | ||