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===Microscopic=== | ===Microscopic=== | ||
Features: | Features: | ||
*Basophilic cells. | #Basal component. | ||
*Usu. nests | #*Basophilic cells - '''key feature'''. | ||
#*Usu. in nests. | |||
#**May be bilayered tubules ''or'' [[trabeculae]]. | |||
#*Large basophilic nucleus. | |||
#*Minimal-to-moderate eosinophilic cytoplasm. | |||
#Stromal cells. | |||
#*Plump spindle cells without significant nuclear atypia - '''distinguishing feature'''. | |||
#*Dense hyaline stroma. | |||
#Tubular component. | |||
#*Within basal component, may be minimal. | |||
#Lesion is encapsulated. | |||
Notes: | Notes: | ||
*No chondromyxoid stroma. | *No chondromyxoid stroma. | ||
**Chondromyxoid stroma present -> pleomorphic adenoma. | **Chondromyxoid stroma present -> [[pleomorphic adenoma]]. | ||
*Neoplastic cells | *Neoplastic cells embedded in stroma ("stromal invasion") = basal cell adenocarcinoma. | ||
**Basal cell adenocarcinoma may be cytologically indistinguishable from basal cell adenoma, i.e. "bad" architecture makes it a basal cell adenocarcinoma. | **Basal cell adenocarcinoma may be cytologically indistinguishable from basal cell adenoma, i.e. "bad" architecture makes it a basal cell adenocarcinoma. | ||
DDx: | |||
*[[Adenoid cystic carcinoma]]. | |||
**Not encapsulated. | |||
*[[Canalicular adenoma]]. | |||
**Different site - CA in oral cavity, usu. upper lip. | |||
Images: | |||
*[http://moon.ouhsc.edu/kfung/jty1/Com/ComImage/Com304-3-LM1.gif BCA (ouhsc.edu)].<ref>URL: [http://moon.ouhsc.edu/kfung/jty1/Com/Com304-3-Diss.htm http://moon.ouhsc.edu/kfung/jty1/Com/Com304-3-Diss.htm]. Accessed on: 25 October 2011.</ref> | |||
*[http://www.webpathology.com/image.asp?n=4&Case=115 BCA (webpathology.com)]. | |||
===IHC=== | ===IHC=== | ||
*Luminal stains +ve: CK7 +ve, CAM5.2 +ve. | *Luminal stains +ve: CK7 +ve, CAM5.2 +ve. | ||
*p63 +ve -- basal component. | |||
*S100 +ve -- spindle cells in the stroma. | |||
==Canalicular adenoma== | ==Canalicular adenoma== |
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