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Difference between revisions of "Kidney tumours"
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===Histology=== | ===Histology=== | ||
*Eosinophilic cytoplasm '''key feature'''. | Features: | ||
*Eosinophilic cytoplasm - slightly granular '''key feature'''. | |||
*Cells arranged in nests. | *Cells arranged in nests. | ||
*Nuclei uniform and round.<ref name=Ref_GUP302>{{Ref GUP|302}}</ref> | *Nuclei uniform and round.<ref name=Ref_GUP302>{{Ref GUP|302}}</ref> | ||
**Slightly enlarged nuclei, but '''no significant''' pleomorphism (size variation) - '''important'''. | |||
Notes: | Notes: | ||
*May look like eosinophilic variant of chromophobe RCC -- this is the main DDx. | *May look like eosinophilic variant of chromophobe RCC -- this is the main DDx. | ||
**May need IHC to differentiate (CK7: oncocytoma = cytoplasm +ve, chromophobe = cell membrane +ve). | **May need IHC to differentiate (CK7: oncocytoma = cytoplasm +ve, chromophobe = cell membrane +ve). | ||
**No perinuclear clearing -- this is seen in ChRCC. | |||
Images: | Images: | ||
*[http://commons.wikimedia.org/wiki/File:Renal_oncocytoma2.jpg High mag. oncocytoma ( | *[http://commons.wikimedia.org/wiki/File:Renal_oncocytoma2.jpg High mag. oncocytoma (WC)]. | ||
*[http://commons.wikimedia.org/wiki/File:Renal_oncocytoma3.jpg Intermed. mag. oncocytoma ( | *[http://commons.wikimedia.org/wiki/File:Renal_oncocytoma3.jpg Intermed. mag. oncocytoma (WC)]. | ||
*[http://commons.wikimedia.org/wiki/File:Renal_oncocytoma4.jpg Low mag. oncocytoma ( | *[http://commons.wikimedia.org/wiki/File:Renal_oncocytoma4.jpg Low mag. oncocytoma (WC)]. | ||
==Angiomyolipoma== | ==Angiomyolipoma== | ||