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Difference between revisions of "Kidney tumours"
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→Renal epithelial stromal tumour: split into 'cystic nephroma' and 'mixed epithelial stromal tumour'
m (→Microscopic) |
(→Renal epithelial stromal tumour: split into 'cystic nephroma' and 'mixed epithelial stromal tumour') |
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*CK7 -ve. | *CK7 -ve. | ||
== | ==Mixed epithelial stromal tumour== | ||
*Abbreviated '' | *Abbreviated ''MEST''. | ||
===General=== | ===General=== | ||
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===IHC=== | ===IHC=== | ||
Features:<ref name=pmid17454754>PMID 17454754</ref> | Features:<ref name=pmid17454754>{{Cite journal | last1 = Mai | first1 = KT. | last2 = Elkeilani | first2 = A. | last3 = Veinot | first3 = JP. | title = Mixed epithelial and stromal tumour (MEST) of the kidney: report of 14 cases with male and PEComatous variants and proposed histopathogenesis. | journal = Pathology | volume = 39 | issue = 2 | pages = 235-40 | month = Apr | year = 2007 | doi = 10.1080/00313020701230799 | PMID = 17454754 }} | ||
</ref> | |||
*ER +ve. | *ER +ve. | ||
*PR +ve. | *PR +ve. | ||
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===DDx=== | ===DDx=== | ||
*Tubulocystic carcinoma. | *Tubulocystic carcinoma. | ||
==Cystic nephroma== | |||
===General=== | |||
*Some consider ''cystic nephroma'' and ''mixed epithelial stromal tumour (MEST)'' to be one tumour. | |||
**The lumping term ''renal epithelial stromal tumour'', abbreviated ''REST''.<ref>{{Cite journal | last1 = Turbiner | first1 = J. | last2 = Amin | first2 = MB. | last3 = Humphrey | first3 = PA. | last4 = Srigley | first4 = JR. | last5 = De Leval | first5 = L. | last6 = Radhakrishnan | first6 = A. | last7 = Oliva | first7 = E. | title = Cystic nephroma and mixed epithelial and stromal tumor of kidney: a detailed clinicopathologic analysis of 34 cases and proposal for renal epithelial and stromal tumor (REST) as a unifying term. | journal = Am J Surg Pathol | volume = 31 | issue = 4 | pages = 489-500 | month = Apr | year = 2007 | doi = 10.1097/PAS.0b013e31802bdd56 | PMID = 17414095 }}</ref> - some believe these are separate entities. | |||
===Gross=== | |||
*Bubble wrap-like appearance. | |||
Image: | |||
*[http://commons.wikimedia.org/wiki/File:Bubble_Wrap.jpg Bubble wrap (WC)]. | |||
===Microscopic=== | |||
Features: | |||
*Cysts lined by simple epithelium with hobnailing - '''key feature'''. | |||
*Stroma has an ovarian look: | |||
**''Blue'' (basophilic). | |||
**''Spindle cells''. | |||
Notes: | |||
*Parenchymal elements (e.g. glomueruli, tubules) are not found in the septa between the cysts. | |||
Images: | |||
*[http://commons.wikimedia.org/wiki/File:Cystic_nephroma_low_mag.jpg Cystic nephroma - low mag. (WC)]. | |||
*[http://commons.wikimedia.org/wiki/File:Cystic_nephroma_intermed_mag.jpg Cystic nephroma - intermed. mag. (WC)]. | |||
===IHC=== | |||
Features: | |||
*ER +ve. | |||
*PR +ve. | |||
*CD10 +ve. | |||
==Renal mucinous tubular and spindle cell carcinoma== | ==Renal mucinous tubular and spindle cell carcinoma== | ||