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Difference between revisions of "Kidney tumours"
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→Chromophobe renal cell carcinoma: clean-up
m (→Microscopic) |
(→Chromophobe renal cell carcinoma: clean-up) |
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Notes: | Notes: | ||
*May have [[psammoma bodies]]. | *May have [[psammoma bodies]]. | ||
DDx: | |||
#Clear cell RCC (classic). | |||
#*Perinuclear clearing is ''not'' seen in clear cell RCC. | |||
#*ChRCC has wisps in the cytoplasm. | |||
====Eosinophilic variant==== | ====Eosinophilic variant==== | ||
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Notes: | Notes: | ||
#May have [[psammoma bodies]]. | #May have [[psammoma bodies]]. | ||
# | |||
DDx: | |||
#[[Renal oncocytoma|Oncocytoma]] - particularly the eosinophilic variant. | |||
#*IHC may be useful to differentiate (CK7: oncocytoma = cytoplasm +ve, chromophobe = cell membrane +ve). | |||
#*A comparison based on histomorphology: ''[[Kidney_tumours#Tabular_comparison_of_oncocytoma_and_chromophobe_RCC|Tabular comparison between ChRCC & oncocytoma]]''. | #*A comparison based on histomorphology: ''[[Kidney_tumours#Tabular_comparison_of_oncocytoma_and_chromophobe_RCC|Tabular comparison between ChRCC & oncocytoma]]''. | ||
#** | #**Oncocytoma typically has: no perinuclear clearing, no raisinoid nuclei, no binucleation. | ||
#Clear cell RCC, eosinophilic variant. | |||
#*Perinuclear clearing is ''not'' seen in clear cell RCC. | |||
#*ChRCC has wisps in the cytoplasm. | |||
Image: | Image: | ||
*[http://commons.wikimedia.org/wiki/File:Oncocytic_chromophobe_rcc_high_mag.jpg Oncocytic chromophobe RCC (WC)]. | *[http://commons.wikimedia.org/wiki/File:Oncocytic_chromophobe_rcc_high_mag.jpg Oncocytic chromophobe RCC (WC)]. | ||
===IHC=== | ===IHC=== | ||