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Difference between revisions of "Kidney tumours"
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→Clear cell renal cell carcinoma
m (→Mesenchymal tumours: fix it is sarcoma) |
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==Clear cell renal cell carcinoma== | ==Clear cell renal cell carcinoma== | ||
*Often abbreviated ''CRCC''. | *Often abbreviated ''CRCC''. | ||
===General=== | |||
*Most common subtype of RCC. | |||
===Gross=== | ===Gross=== | ||
*Gold/yellow. | *Gold/yellow. | ||
*+/-Haemorrhage (common). | *+/-Haemorrhage (common). | ||
*+/-Necrosis (common in large tumours). | *+/-Necrosis (common in large tumours). | ||
*+/-Calcification. | |||
*+/-Cysts. | |||
===Microscopic=== | ===Microscopic=== | ||
Features:<ref name=Ref_PBoD1017-8>{{Ref PBoD|1017-8}}</ref> | Features:<ref name=Ref_PBoD1017-8>{{Ref PBoD|1017-8}}</ref> | ||
*Solid or [[trabecular]] pattern. | *Solid or [[trabecular]] pattern. | ||
*Polygonal cells. | |||
*Clear cytoplasm. | |||
*Central nucleus. | |||
*Delicate branching vasculature. | *Delicate branching vasculature. | ||
Notes: | Notes: | ||
*Cytoplasm may be eosinophilic.<ref name=Ref_WMSP291>{{Ref WMSP|291}}</ref> | |||
*[[Hyaline bodies]] common.<ref>AFIP Renal Tumours Book.</ref> | *[[Hyaline bodies]] common.<ref>AFIP Renal Tumours Book.</ref> | ||
**Not common in papillary RCC. | **Not common in papillary RCC. | ||
Clear cell vs. [[adrenocortical carcinoma]]: | |||
*ACC: EMA- (epithelial membrane antigen), cytokeratin mostly neg., inhibin+ (neg. in RCC).<ref name=Ref_GUP285>{{Ref GUP|285}}</ref> | |||
===IHC=== | ===IHC=== | ||
| Line 341: | Line 353: | ||
*CK20 -ve. | *CK20 -ve. | ||
*Hale's colloidal iron -ve. | *Hale's colloidal iron -ve. | ||
**+ve in chromophobe. | **+ve in chromophobe RCC. | ||
Note: ''[[Hale's colloidal iron]]'' does not stain iron... it stains hemosiderin.<ref>Latta. 27 January 2009.</ref> | Note: ''[[Hale's colloidal iron]]'' does not stain iron... it stains hemosiderin.<ref>Latta. 27 January 2009.</ref> | ||
Clear cell vs. chromophobe: | Clear cell vs. chromophobe: | ||
*Chromophobe: "translucent" (NOT quite clear), reticulated, | *Chromophobe: "translucent" (NOT quite clear), reticulated, Hale's colloidal iron stain+, CK7+ (cell membrane). | ||
==Papillary renal cell carcinoma== | ==Papillary renal cell carcinoma== | ||