Talk:Non-malignant skin disease

Urticaria

Microscopic description

The sections show a mild, superficial dermal perivascular lymphoeosinophilic infiltration. Rare eosinophils are seen in the dermis distant from blood vessels. The epidermis shows normal maturation and is not inflamed. No dysplastic changes are present.

Final diagnosis

A. Skin, posterior left thigh, biopsy - dermal perivascular lymphoeosinophilic infiltration, see comment.

Comment

The sections show a mild, superficial dermal perivascular lymphoeosinophilic infiltration. Rare eosinophils are seen in the dermis distant from blood vessels. The epidermis shows normal maturation and is not inflammed.

Pilomatrixoma

Microscopic description

The sections show a fibrous encapsulated lesion with nests of benign basaloid squamous cells, occasional squamous pearls, multi-nucleated foreign body-type giant cells, and abundant anucleated squamous cells ("ghost cells"). Focal, punctate calcifications are present. Small collections of lymphocytes are present. There is no evidence of dysplasia.

Final diagnosis

Neck mass, left, excision - Pilomatrixoma

Dermatofibroma

Microscopic description

Sections show a well-circumscribed deep dermal, cellular lesion with thick bundles of collagen through-out. The predominant cell type has regular, pale vesicular nuclei without prominent nucleoli and moderate pale cytoplasm. No mitotic activity is present. Histocytes and lymphocytes are present focally. The lesion is incompletely excised. The overlying epidermis and superficial dermis have no pathology.

Final diagnosis

Soft tissue, right anterior calf, excision: - Cellular dermatofibroma.

Dupuytren contracture

Microscopic description

The sections show bland spindle cells in dense collagen. No nuclear atypia is seen.

Final diagnosis

Palmar fascia, left hand, excision:
- FIBROMATOSIS CONSISTENT WITH DUPUYTREN'S CONTRACTURE.

Frictional keratosis

Microscopic

Multiple levels show stratified squamous epithelium with focal ulceration, fibrin, and reactive inflammation consisting predominantly of neutrophils, and, to a lesser extent, from lymphocytes and plasma cells. There is keratosis of the epithelium, a prominent granular cell layer and acanthosis. Moderate dermal fibrosis is present. No viral cytopathic changes are identified. PAS staining does not identify microorganisms.

Final diagnosis

Tongue, left posterior lateral, biopsy:
-FOCAL ULCERATION WITH REGENERATION/REPARATIVE EPITHELIAL HYPERPLASIA.
-NEGATIVE FOR DYSPLASIA.
-PAS STAIN NEGATIVE FOR MICROORGANISMS.

Pigmented seborrheic keratosis

Microscopic

The sections show skin with acanthosis, horn cysts, and keratinocyte hyperpigmentation. Solar elastosis is present.

Final diagnosis

Skin, right preauricular area, biopsy:
- PIGMENTED SEBORRHEIC KERATOSIS.
- EXTENSIVE SOLAR ELASTOSIS.

Dermal scar

Microscopic

The sections show skin with dense collagen fibres running parallel to the dermal-epidermal junction. There is focal loss of the rete ridges and adnexal structures.

Final diagnosis

Skin, scalp graft, excision:
- MATURE HYALINIZED DERMAL SCAR.
- NEGATIVE FOR ATYPIA AND MALIGNANCY.