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Difference between revisions of "Dermatologic neoplasms"
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Dermatologic neoplasms (view source)
Revision as of 20:03, 20 September 2011
, 20:03, 20 September 2011→Benign: move from non-malign. skin
(→Subtypes/unique features: more) |
(→Benign: move from non-malign. skin) |
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=Benign= | =Benign= | ||
==Syringoma== | |||
===General=== | |||
*Benign sweat duct tumour. | |||
*Eccrine differentiation. | |||
*Usually close to lower eyelid.<ref>{{Ref PBoD8|1177}}</ref> | |||
===Microscopic=== | |||
Features:<ref>URL: [http://emedicine.medscape.com/article/1059871-diagnosis http://emedicine.medscape.com/article/1059871-diagnosis]. Accessed on: 12 May 2010.</ref> | |||
*Proliferation of benign ducts with lined by a bilayer (as in normal sweat ducts) with abnormal architecture: | |||
**Tadpole like appearing ducts. | |||
Images: | |||
*[http://www.flickr.com/photos/euthman/2329061316/ Syringoma (flickr.com)]. | |||
*[http://dermatology.cdlib.org/144/tumors/axillary_syringoma/2.jpg Syringoma (dermatology.cdlib.org)].<ref>{{Cite journal | last1 = Nosrati | first1 = N. | last2 = Coleman | first2 = NM. | last3 = Hsu | first3 = S. | title = Axillary syringomas. | journal = Dermatol Online J | volume = 14 | issue = 4 | pages = 13 | month = | year = 2008 | doi = | PMID = 18627735 |URL = http://dermatology.cdlib.org/144/tumors/axillary_syringoma/hsu.html}}</ref> | |||
==Chondroid syringoma== | |||
*Used to be called ''mixed tumour of skin''.<ref name=pmid19693940>{{Cite journal | last1 = Kumar | first1 = B. | title = Chondroid syringoma diagnosed by fine needle aspiration cytology. | journal = Diagn Cytopathol | volume = 38 | issue = 1 | pages = 38-40 | month = Jan | year = 2010 | doi = 10.1002/dc.21159 | PMID = 19693940 }}</ref> | |||
===General=== | |||
*Mixed apocrine & eccrine tumour of skin, usu. in the head & neck<ref name=pmid19693940/>, esp. nose and cheek.<ref name=pmid19633639/> | |||
*May be in major and minor salivary glands.<ref name=pmid19633639>{{Cite journal | last1 = Rauso | first1 = R. | last2 = Santagata | first2 = M. | last3 = Tartaro | first3 = G. | last4 = Filipi | first4 = M. | last5 = Colella | first5 = G. | title = Chondroid syringoma: a rare tumor of orofacial region. | journal = Minerva Stomatol | volume = 58 | issue = 7-8 | pages = 383-8 | month = | year = | doi = | PMID = 19633639 }}</ref> | |||
===Microscopic=== | |||
Features: | |||
*Mix tumour with:<ref name=pmid19693940/> | |||
*#Epithelial component: | |||
*#*Nests of cells with: | |||
*#**Moderate dull eosinophilic cytoplasm. | |||
*#**Round/ovoid nuclei with nucleoli. | |||
*#Mesenchymal component: | |||
*#*Chondromyxoid stroma. | |||
==Dermal cylindroma== | |||
===General=== | |||
*Benign skin lesion. | |||
*Should not be confused with ''cylindroma'' ([[adenoid cystic carcinoma]]). | |||
===Microscopic=== | |||
Features: | |||
*Nests of cells that are surrounded by hyaline (i.e. glassy, eosinophilic, acellular) material. | |||
DDx: | |||
*[[Eccrine spiradenoma]]. | |||
Images: | |||
*[http://commons.wikimedia.org/wiki/File:Dermal_cylindroma_intermed_mag.jpg Dermal cylindroma (WC)]. | |||
*[http://commons.wikimedia.org/wiki/File:Dermal_cylindroma_intermed_mag_deep.jpg Dermal cylindroma - high mag. (WC)]. | |||
==Keratoacanthoma== | |||
*Abbreviated ''KA''. | |||
*Generally considered to be benign. | |||
**Rare reports of metastases suggesting it may be a form of squamous cell carcinoma.<ref>{{cite journal |author=Mandrell JC, Santa Cruz D |title=Keratoacanthoma: hyperplasia, benign neoplasm, or a type of squamous cell carcinoma? |journal=Semin Diagn Pathol |volume=26 |issue=3 |pages=150–63 |year=2009 |month=August |pmid=20043514 |doi= |url=}}</ref> | |||
===Clinical=== | |||
*May grow rapidly (weeks or months) then involute. | |||
*Main DDx is [[squamous cell carcinoma]]. | |||
*Exophytic lesion, well-circumscribed. | |||
===Microscopic=== | |||
Features:<ref>{{Ref Klatt|378}}</ref> | |||
*Expansion of stratum spinosum - pushing tongue-like downward growth of epidermis into the dermis. | |||
*Keratin collection (keratin plug) at the center of lesion-superficial aspect. | |||
*Cells have glassy pink cytoplasm. | |||
*Minimal/no nuclear atypia. | |||
Image: | |||
*[http://commons.wikimedia.org/wiki/File:Skin_keratoacanthoma_whole_slide.jpg Keratocanthoma (WC).] | |||
==Sebaceous adenoma== | ==Sebaceous adenoma== | ||