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*UC patients get pouches... CD patients do not. | *UC patients get pouches... CD patients do not. | ||
**It is said that: ''There 's nothing like a pouch to bring out Crohn's disease''.<ref>URL: [http://www.gihealthfoundation.org/library/ppts/postcolectomypatient.pdf http://www.gihealthfoundation.org/library/ppts/postcolectomypatient.pdf]. 3 March 2011.</ref> | **It is said that: ''There 's nothing like a pouch to bring out Crohn's disease''.<ref>URL: [http://www.gihealthfoundation.org/library/ppts/postcolectomypatient.pdf http://www.gihealthfoundation.org/library/ppts/postcolectomypatient.pdf]. 3 March 2011.</ref> | ||
*People with long standing IBD have an increased risk for: | |||
**Carcinoma - usually [[colorectal carcinoma]].<ref name=pmid21640928>{{Cite journal | last1 = Claessen | first1 = MM. | last2 = Siersema | first2 = PD. | last3 = Vleggaar | first3 = FP. | title = IBD-related carcinoma. | journal = Best Pract Res Clin Gastroenterol | volume = 25 Suppl 1 | issue = | pages = S27-38 | month = Apr | year = 2011 | doi = 10.1016/S1521-6918(11)70007-5 | PMID = 21640928 }}</ref> | |||
***Small increased risk for [[small bowel]] adenocarcinoma in Crohn's disease.<ref name=pmid21640928/> | |||
**Lymphoma - in association with thiopurine use.<ref name=pmid21830262>{{Cite journal | last1 = Vos | first1 = AC. | last2 = Bakkal | first2 = N. | last3 = Minnee | first3 = RC. | last4 = Casparie | first4 = MK. | last5 = de Jong | first5 = DJ. | last6 = Dijkstra | first6 = G. | last7 = Stokkers | first7 = P. | last8 = van Bodegraven | first8 = AA. | last9 = Pierik | first9 = M. | title = Risk of malignant lymphoma in patients with inflammatory bowel diseases: A Dutch nationwide study. | journal = Inflamm Bowel Dis | volume = 17 | issue = 9 | pages = 1837-1845 | month = Sep | year = 2011 | doi = 10.1002/ibd.21582 | PMID = 21830262 }}</ref> | |||
===Molecular=== | |||
*NOD2/CARD15 variants are assoc. with stricturing CD, early need for surgery and recurrence.<ref name=pmid16244543 >{{cite journal |author=Alvarez-Lobos M, Arostegui JI, Sans M, ''et al.'' |title=Crohn's disease patients carrying Nod2/CARD15 gene variants have an increased and early need for first surgery due to stricturing disease and higher rate of surgical recurrence |journal=Ann. Surg. |volume=242 |issue=5 |pages=693–700 |year=2005 |month=November |pmid=16244543 |pmc=1409853 |doi= |url=}}</ref> | |||
===General clinical differential diagnosis=== | ===General clinical differential diagnosis=== | ||
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Others: | Others: | ||
*[[Irritable bowel syndrome]]. | *[[Irritable bowel syndrome]]. | ||
==Microscopic== | ==Microscopic== |
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