Difference between revisions of "Neuroendocrine neoplasms"
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#Mixed adenoneuroendocrine carcinoma. | #Mixed adenoneuroendocrine carcinoma. | ||
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{{Cite journal | last1 = Volante | first1 = M. | last2 = Righi | first2 = L. | last3 = Berruti | first3 = A. | last4 = Rindi | first4 = G. | last5 = Papotti | first5 = M. | title = The pathological diagnosis of neuroendocrine tumors: common questions and tentative answers. | journal = Virchows Arch | volume = 458 | issue = 4 | pages = 393-402 | month = Apr | year = 2011 | doi = 10.1007/s00428-011-1060-7 | PMID = 21344263 }} | {{Cite journal | last1 = Volante | first1 = M. | last2 = Righi | first2 = L. | last3 = Berruti | first3 = A. | last4 = Rindi | first4 = G. | last5 = Papotti | first5 = M. | title = The pathological diagnosis of neuroendocrine tumors: common questions and tentative answers. | journal = Virchows Arch | volume = 458 | issue = 4 | pages = 393-402 | month = Apr | year = 2011 | doi = 10.1007/s00428-011-1060-7 | PMID = 21344263 }} | ||
Revision as of 03:34, 12 August 2011
Neuroendocrine neoplasms, also neuroendocrine tumours, are a group of tumours whose behaviour varies from benign to malignant and are found in may different sites.
Use of the term carcinoid
Use of the term carcinoid is discouraged.[1][2][3]
Microscopic - generic
Features:
- Nests of cells.
- Stippled chromatin AKA salt-and-pepper chromatin, coarse chromatin.
- Classically subepithelial/mural.
Images:
- Neuroendocrine tumour - low mag. (WC).
- Neuroendocrine tumour - intermed. mag. (WC).
- Neuroendocrine tumour - high mag. (WC).
Site specific
Lung
Main article: Lung_tumours#Neuroendocrine_tumours
GI tract
Main article: Duodenum#Neuroendocrine_tumours
WHO classification
Subtypes:[4]
- Neuroendocrine tumour G1.
- Neuroendocrine tumor G2.
- Neuroendocrine carcinoma, small cell type.
- Neuroendocrine carcinoma, large cell type.
- Mixed adenoneuroendocrine carcinoma.
Further reading:
Volante, M.; Righi, L.; Berruti, A.; Rindi, G.; Papotti, M. (Apr 2011). "The pathological diagnosis of neuroendocrine tumors: common questions and tentative answers.". Virchows Arch 458 (4): 393-402. doi:10.1007/s00428-011-1060-7. PMID 21344263.
See also
References
- ↑ Chetty, R. (Apr 2008). "Requiem for the term 'carcinoid tumour' in the gastrointestinal tract?". Can J Gastroenterol 22 (4): 357-8. PMID 18414708.
- ↑ Klöppel, G.; Perren, A.; Heitz, PU. (Apr 2004). "The gastroenteropancreatic neuroendocrine cell system and its tumors: the WHO classification.". Ann N Y Acad Sci 1014: 13-27. PMID 15153416.
- ↑ Klöppel G (July 2003). "[Neuroendocrine tumors of the gastrointestinal tract]" (in German). Pathologe 24 (4): 287–96. doi:10.1007/s00292-003-0636-7. PMID 14513276.
- ↑ Scoazec, JY.; Couvelard, A. (Apr 2011). "[The new WHO classification of digestive neuroendocrine tumors].". Ann Pathol 31 (2): 88-92. doi:10.1016/j.annpat.2011.01.001. PMID 21601112.