Difference between revisions of "Small cell carcinoma"
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'''Small cell carcinoma''' is a type of carcinoma. It is mostly commonly from the [[lung tumours|lung]] ~95% of cases.<ref name=pmid21618245/> | '''Small cell carcinoma''' is a type of carcinoma. It is mostly commonly from the [[lung tumours|lung]] ~95% of cases.<ref name=pmid21618245/> | ||
== | ==Overview== | ||
===Grouping=== | |||
May be grouped as:<ref name=pmid21618245>{{Cite journal | last1 = Grossman | first1 = RA. | last2 = Pedroso | first2 = FE. | last3 = Byrne | first3 = MM. | last4 = Koniaris | first4 = LG. | last5 = Misra | first5 = S. | title = Does surgery or radiation therapy impact survival for patients with extrapulmonary small cell cancers? | journal = J Surg Oncol | volume = | issue = | pages = | month = May | year = 2011 | doi = 10.1002/jso.21976 | PMID = 21618245 }}</ref> | May be grouped as:<ref name=pmid21618245>{{Cite journal | last1 = Grossman | first1 = RA. | last2 = Pedroso | first2 = FE. | last3 = Byrne | first3 = MM. | last4 = Koniaris | first4 = LG. | last5 = Misra | first5 = S. | title = Does surgery or radiation therapy impact survival for patients with extrapulmonary small cell cancers? | journal = J Surg Oncol | volume = | issue = | pages = | month = May | year = 2011 | doi = 10.1002/jso.21976 | PMID = 21618245 }}</ref> | ||
*[[Lung|Pulmonary]]. | *[[Lung|Pulmonary]]. | ||
| Line 14: | Line 11: | ||
*Other. | *Other. | ||
== | ===Sites other than lung=== | ||
*Breast.<ref name=pmid21657157>{{Cite journal | last1 = Cesaretti | first1 = M. | last2 = Guarnieri | first2 = A. | last3 = Gaggelli | first3 = I. | last4 = Tirone | first4 = A. | last5 = Francioli | first5 = N. | last6 = Carli | first6 = AF. | title = Small cell carcinoma of the breast. Report of a case. | journal = Ann Ital Chir | volume = 82 | issue = 1 | pages = 61-4 | month = | year = | doi = | PMID = 21657157 }}</ref> | |||
*Thyroid gland.<ref name=pmid21644012>{{Cite journal | last1 = Beach | first1 = DF. | last2 = Klump | first2 = WJ. | last3 = Haddad | first3 = G. | last4 = Reid | first4 = LM. | last5 = Schwarting | first5 = R. | last6 = Hageboutros | first6 = A. | title = Extrapulmonary small cell: a novel case of small cell carcinoma of the thyroid gland. | journal = Med Oncol | volume = | issue = | pages = | month = Jun | year = 2011 | doi = 10.1007/s12032-011-9996-7 | PMID = 21644012 }}</ref> | |||
==Microscopic== | |||
Features: | |||
*Small cells -- typically 15-20 micrometers ~ 2x the size of [[RBC]]. | |||
*Scant cytoplasm. | |||
*Stippled chromatin. | |||
*+/-Nuclear moulding. | |||
Images: | |||
*[http://commons.wikimedia.org/wiki/File:Small_cell_lung_cancer_-_cytology.jpg Small cell carcinoma - cytology (WC)]. | |||
*[http://commons.wikimedia.org/wiki/File:Metastatic_small_cell_carcinoma_-_high_mag.jpg Metastatic small cell carcinoma - high mag. (WC)]. | |||
*[http://commons.wikimedia.org/wiki/File:Metastatic_small_cell_carcinoma_-_very_high_mag.jpg Metastatic small cell carcinoma - very high mag. (WC)]. | |||
DDx: | |||
*[[Small round cell tumours]]. | *[[Small round cell tumours]]. | ||
*[[Chloroma]]. | *[[Chloroma]]. | ||
Revision as of 16:23, 24 July 2011
Small cell carcinoma is a type of carcinoma. It is mostly commonly from the lung ~95% of cases.[1]
Overview
Grouping
May be grouped as:[1]
- Pulmonary.
- Gastrointestinal.
- Genitourinary.
- Head & neck.
- Breast.
- Other.
Sites other than lung
Microscopic
Features:
- Small cells -- typically 15-20 micrometers ~ 2x the size of RBC.
- Scant cytoplasm.
- Stippled chromatin.
- +/-Nuclear moulding.
Images:
- Small cell carcinoma - cytology (WC).
- Metastatic small cell carcinoma - high mag. (WC).
- Metastatic small cell carcinoma - very high mag. (WC).
DDx:
See also
- Lung tumours.
- Azzopardi phenomenon.
- Chloroma (AKA granulocytic sarcoma, myeloid sarcoma).
References
- ↑ 1.0 1.1 Grossman, RA.; Pedroso, FE.; Byrne, MM.; Koniaris, LG.; Misra, S. (May 2011). "Does surgery or radiation therapy impact survival for patients with extrapulmonary small cell cancers?". J Surg Oncol. doi:10.1002/jso.21976. PMID 21618245.
- ↑ Cesaretti, M.; Guarnieri, A.; Gaggelli, I.; Tirone, A.; Francioli, N.; Carli, AF.. "Small cell carcinoma of the breast. Report of a case.". Ann Ital Chir 82 (1): 61-4. PMID 21657157.
- ↑ Beach, DF.; Klump, WJ.; Haddad, G.; Reid, LM.; Schwarting, R.; Hageboutros, A. (Jun 2011). "Extrapulmonary small cell: a novel case of small cell carcinoma of the thyroid gland.". Med Oncol. doi:10.1007/s12032-011-9996-7. PMID 21644012.