Complex endometrial hyperplasia: Difference between revisions
Jump to navigation
Jump to search
m sm |
m touch |
||
| (3 intermediate revisions by the same user not shown) | |||
| Line 3: | Line 3: | ||
| Image = Complex endometrial hyperplasia -- intermed mag.jpg | | Image = Complex endometrial hyperplasia -- intermed mag.jpg | ||
| Width = | | Width = | ||
| Caption = Complex endometrial hyperplasia. [[H&E stain]]. | | Caption = Complex endometrial hyperplasia. [[H&E stain]]. | ||
| Micro = increase in size & number of glands + irregular shape, nuclear pseudostratification, nuclear enlargement, mitoses common, +/-nuclear atypia (round nuclei ~ 2-3x the size of a lymphocyte, grey/translucent chromatin, nucleoli) | | Micro = increase in size & number of glands + irregular shape, nuclear pseudostratification, nuclear enlargement, mitoses common, +/-nuclear atypia (round nuclei ~ 2-3x the size of a lymphocyte, grey/translucent chromatin, nucleoli) | ||
| Subtypes = CEH [[NOS]] (CEH without atypia), CEH with atypia | | Subtypes = CEH [[NOS]] (CEH without atypia), CEH with atypia | ||
| Line 13: | Line 13: | ||
| IF = | | IF = | ||
| Gross = thickened endometrium | | Gross = thickened endometrium | ||
| Grossing = | | Grossing = [[hysterectomy for endometrial hyperplasia grossing]] | ||
| Site = [[endometrium]] - see ''[[endometrial hyperplasia]] | | Site = [[endometrium]] - see ''[[endometrial hyperplasia]] | ||
| Assdx = [[obesity]], [[endometrium with squamous morules]] | | Assdx = [[obesity]], [[endometrium with squamous morules]] | ||
| Line 69: | Line 69: | ||
DDx: | DDx: | ||
*Artifactual gland crowding due to fragmentation - white space around the glands. | *Artifactual gland crowding due to fragmentation - white space around the glands. | ||
*Endometrial gland coiling - no sharp transition, moderate stroma between the glands horizontally. | *[[Endometrial gland coiling]] - no sharp transition, moderate stroma between the glands horizontally. | ||
*[[Endometrioid endometrial carcinoma]] - see ''[[endometrial carcinoma versus complex endometrial hyperplasia]]''. | *[[Endometrioid endometrial carcinoma]] - see ''[[endometrial carcinoma versus complex endometrial hyperplasia]]''. | ||
*Benign papillary proliferation of the endometrium.<ref name=pmid23211295>{{Cite journal | last1 = Ip | first1 = PP. | last2 = Irving | first2 = JA. | last3 = McCluggage | first3 = WG. | last4 = Clement | first4 = PB. | last5 = Young | first5 = RH. | title = Papillary proliferation of the endometrium: a clinicopathologic study of 59 cases of simple and complex papillae without cytologic atypia. | journal = Am J Surg Pathol | volume = 37 | issue = 2 | pages = 167-77 | month = Feb | year = 2013 | doi = 10.1097/PAS.0b013e318272d428 | PMID = 23211295 }}</ref> | *Benign papillary proliferation of the endometrium.<ref name=pmid23211295>{{Cite journal | last1 = Ip | first1 = PP. | last2 = Irving | first2 = JA. | last3 = McCluggage | first3 = WG. | last4 = Clement | first4 = PB. | last5 = Young | first5 = RH. | title = Papillary proliferation of the endometrium: a clinicopathologic study of 59 cases of simple and complex papillae without cytologic atypia. | journal = Am J Surg Pathol | volume = 37 | issue = 2 | pages = 167-77 | month = Feb | year = 2013 | doi = 10.1097/PAS.0b013e318272d428 | PMID = 23211295 }}</ref> | ||
| Line 174: | Line 174: | ||
for the diagnosis of endometrial carcinoma. | for the diagnosis of endometrial carcinoma. | ||
</pre> | </pre> | ||
====Micro==== | |||
=====CEH with atypia===== | |||
The sections show endometrium with atypical hyperchromatic, densely packed branching glands. The nuclei of the atypical glands focally are round, 2-3x the size of a lymphocyte, and have grey/translucent chromatin and small nucleoli. No papillary or cribriform changes are appreciated. No desmoplastic stroma is identified. | |||
==See also== | ==See also== | ||