ABCC2: Difference between revisions
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==Papillary renal cell carcinoma== | ==Papillary renal cell carcinoma== | ||
ABCC2 staining is predictive of outcome in [[papillary renal cell carcinoma]] | ABCC2 staining is predictive of outcome in [[papillary renal cell carcinoma]]: | ||
*Brush border staining is associated with a worse survival.<ref name=pmid37680023>{{cite journal |authors=Castillo VF, Masoomian M, Trpkov K, Downes M, Brimo F, van der Kwast T, Yousef GM, Zakhary A, Rotondo F, Saad G, Nguyen VN, Kidanewold W, Streutker C, Rowsell C, Hamdani M, Saleeb RM |title=ABCC2 brush-border expression predicts outcome in papillary renal cell carcinoma: a multi-institutional study of 254 cases |journal=Histopathology |volume=83 |issue=6 |pages=949–958 |date=December 2023 |pmid=37680023 |doi=10.1111/his.15042 |url=}}</ref> | |||
*Brush border staining suggests response to immunotherapy.<ref>{{cite journal |authors=Castillo VF, Zakhary A, Rotondo F, Di Ciano-Oliveira C, Hamdani M, Adona E, van der Kwast T, Trpkov K, Saleeb R |title=Papillary renal cell carcinoma with high-ABCC2 shows an immune-evasive profile associated with favorable response to immunotherapy |journal=J Pathol |volume=268 |issue=2 |pages=188–199 |date=February 2026 |pmid=41259021 |doi=10.1002/path.70001 |url=}}</ref> | |||
==Sign out== | |||
===Positive=== | |||
<pre> | |||
ABCC2 brush border staining in the tumour is PRESENT, patchy and estimated as >50%; the presence of significant ABCC2 staining suggests a more aggressive disease.[1] | |||
The findings are in keeping with papillary renal cell carcinoma; the diagnosis is not changed. | |||
1. Histopathology. 2023 Dec;83(6):949-958. doi: 10.1111/his.15042. | |||
</pre> | |||
===Negative=== | |||
<pre> | |||
Significant ABCC2 brush border staining in the tumour is ABSENT (<50%). | |||
</pre> | |||
==References== | ==References== | ||