Squamous cell carcinoma of the penis: Difference between revisions
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| Synonyms = | | Synonyms = | ||
| Micro = | | Micro = | ||
| Subtypes = | | Subtypes = HPV-related SCC, Non-HPV-related SCC | ||
| LMDDx = [[penile intraepithelial neoplasia]], [[pseudoepitheliomatous hyperplasia]] | | LMDDx = [[penile intraepithelial neoplasia]], [[pseudoepitheliomatous hyperplasia]] | ||
| Stains = | | Stains = | ||
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*Median age ~ 67 years old. | *Median age ~ 67 years old. | ||
*Usually a good outcome - 5 year cause specific survival ~ 81%.<ref name=pmid24119832/> | *Usually a good outcome - 5 year cause specific survival ~ 81%.<ref name=pmid24119832/> | ||
*Possible association with sex with animals.<ref>{{Cite journal | last1 = Zequi | first1 = Sde C. | last2 = Guimarães | first2 = GC. | last3 = da Fonseca | first3 = FP. | last4 = Ferreira | first4 = U. | last5 = de Matheus | first5 = WE. | last6 = Reis | first6 = LO. | last7 = Aita | first7 = GA. | last8 = Glina | first8 = S. | last9 = Fanni | first9 = VS. | title = Sex with animals (SWA): behavioral characteristics and possible association with penile cancer. A multicenter study. | journal = J Sex Med | volume = 9 | issue = 7 | pages = 1860-7 | month = Jul | year = 2012 | doi = 10.1111/j.1743-6109.2011.02512.x | PMID = 22023719 }}</ref> | |||
==Gross== | ==Gross== | ||
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*[[Penile intraepithelial neoplasia]] (squamous dysplasia). | *[[Penile intraepithelial neoplasia]] (squamous dysplasia). | ||
*[[Pseudoepitheliomatous hyperplasia]]. | *[[Pseudoepitheliomatous hyperplasia]]. | ||
===Subtyping=== | |||
*''Non-HPV-related squamous cell carcinoma. | |||
**p16 -ve, p53 +ve.{{fact}} | |||
*''HPV-related squamous cell carcinoma''. | |||
**p16 +ve, p53 -ve.{{fact}} | |||
===Grading=== | ===Grading=== | ||
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==IHC== | ==IHC== | ||
*p16 +ve - in types associated with [[HPV]] (basaloid SCC, warty SCC and warty-basaloid SCC.<ref name=pmid22367299>{{Cite journal | last1 = Cubilla | first1 = AL. | last2 = Lloveras | first2 = B. | last3 = Alemany | first3 = L. | last4 = Alejo | first4 = M. | last5 = Vidal | first5 = A. | last6 = Kasamatsu | first6 = E. | last7 = Clavero | first7 = O. | last8 = Alvarado-Cabrero | first8 = I. | last9 = Lynch | first9 = C. | title = Basaloid squamous cell carcinoma of the penis with papillary features: a clinicopathologic study of 12 cases. | journal = Am J Surg Pathol | volume = 36 | issue = 6 | pages = 869-75 | month = Jun | year = 2012 | doi = 10.1097/PAS.0b013e318249c6f3 | PMID = 22367299 }}</ref> | *p16 +ve - in types associated with [[HPV]] (basaloid SCC, warty SCC and warty-basaloid SCC).<ref name=pmid22367299>{{Cite journal | last1 = Cubilla | first1 = AL. | last2 = Lloveras | first2 = B. | last3 = Alemany | first3 = L. | last4 = Alejo | first4 = M. | last5 = Vidal | first5 = A. | last6 = Kasamatsu | first6 = E. | last7 = Clavero | first7 = O. | last8 = Alvarado-Cabrero | first8 = I. | last9 = Lynch | first9 = C. | title = Basaloid squamous cell carcinoma of the penis with papillary features: a clinicopathologic study of 12 cases. | journal = Am J Surg Pathol | volume = 36 | issue = 6 | pages = 869-75 | month = Jun | year = 2012 | doi = 10.1097/PAS.0b013e318249c6f3 | PMID = 22367299 }}</ref> | ||
==Sign out== | ==Sign out== | ||
===Biopsy=== | |||
<pre> | |||
Penis, Biopsy: | |||
- INVASIVE SQUAMOUS CELL CARCINOMA, well differentiated. | |||
Comment: | |||
The tumour has differentiated penile intraepithelial neoplasia adjacent to it. The tumour is p16 negative and p53 positive. | |||
</pre> | |||
===Resection=== | |||
<pre> | <pre> | ||
Tip of Penis, Partial Penectomy: | Tip of Penis, Partial Penectomy: | ||
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invasion is seen. The staging is unchanged. | invasion is seen. The staging is unchanged. | ||
</pre> | </pre> | ||
===Micro=== | |||
The sections show a malignant tumour with moderate to severe anisonucleosis. It focally underlies keratinizing epithelium that matures to the surface. Intracellular bridges are present focally. Keratinization is present. Mitotic activity is easily identified. | |||
==See also== | ==See also== | ||