Vas deferens: Difference between revisions
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The '''vas deferens''' are often seen as part of a [[prostate gland|prostatectomy]] specimen.<ref>URL: [http://www.upmccancercenters.com/cancer/prostate/radprostretropubic.html http://www.upmccancercenters.com/cancer/prostate/radprostretropubic.html]. Accessed on: 26 September 2011.</ref> They are the component of the [[spermatic cord]] that carries the sperm. | [[Image:Normal_Vas_Deferens%2C_Human_%283952564123%29.jpg|thumb|right|Vas deferens. (WC/Ed Uthman)]] | ||
The '''vas deferens''' (plural: vasa deferentia) are often seen as part of a [[prostate gland|prostatectomy]] specimen.<ref>URL: [http://www.upmccancercenters.com/cancer/prostate/radprostretropubic.html http://www.upmccancercenters.com/cancer/prostate/radprostretropubic.html]. Accessed on: 26 September 2011.</ref> They are the component of the [[spermatic cord]] that carries the sperm. | |||
They often arrive alone -- removed for family planning ([[vasectomy]]). | They often arrive alone -- removed for family planning ([[vasectomy]]), where the job of the pathologist is to confirm a full transverse section. | ||
==Normal vas deferens== | ==Normal vas deferens== | ||
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DDx: | DDx: | ||
*Missed vas deferens. | *Missed vas deferens. | ||
**Intermediate size blood vessels +/- denudation. | |||
**Ureter. | |||
*Incomplete vasectomy - only partial lumen. | *Incomplete vasectomy - only partial lumen. | ||
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*CD10 +ve (marker of Wolffian differentiation). | *CD10 +ve (marker of Wolffian differentiation). | ||
*Pankeratin +ve. | *Pankeratin +ve. | ||
*PAX-8 +ve (100%).<ref name=pmid32633248>{{cite journal |authors=Ortiz-Rey JA, Domínguez-de Dios J, Pérez-Schoch M, San Miguel-Fraile P, Gómez-de María C |title=[New immunohistochemistry markers to determine presence of vas deferens in vasectomy specimen.] |language=Spanish; Castilian |journal=Arch Esp Urol |volume=73 |issue=6 |pages=534–540 |date=July 2020 |pmid=32633248 |doi= |url=}}</ref> | |||
*GATA-3 +ve.<ref name=pmid33012491>{{cite journal |authors=Ortiz-Rey JA, Domínguez-de Dios J, Pérez-Schoch M, San Miguel-Fraile P, Gómez-de María C |title=[E-Cadherine and GATA-3 are useful in the confirmation of the vas deferens in vasectomy specimens] |language=Spanish; Castilian |journal=Rev Esp Patol |volume=53 |issue=4 |pages=218–225 |date=2020 |pmid=33012491 |doi=10.1016/j.patol.2020.02.005 |url=}}</ref> | |||
*ERG -ve.<ref name=pmid32633248/> | |||
*CD34 -ve.<ref name=pmid32633248/> | |||
===Sign out=== | ===Sign out=== | ||
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====Left then right==== | ====Left then right==== | ||
<pre> | |||
A. Vas Deferens, Left, Vasectomy: | |||
- Vas deferens within normal limits, loop of epithelium and muscle layers present. | |||
B. Vas Deferens, Right, Vasectomy: | |||
- Vas deferens within normal limits, loop of epithelium and muscle layers present. | |||
</pre> | |||
<pre> | <pre> | ||
A. VAS DEFERENS, LEFT, VASECTOMY: | A. VAS DEFERENS, LEFT, VASECTOMY: | ||
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<pre> | <pre> | ||
VAS DEFERENS, RIGHT AND LEFT, VASECTOMY: | VAS DEFERENS, RIGHT AND LEFT, VASECTOMY: | ||
- VAS DEFERENS WITHIN NORMAL LIMITS, LOOPS OF EPITHELIUM AND MUSCLE LAYERS PRESENT, | - VAS DEFERENS WITHIN NORMAL LIMITS, LOOPS OF EPITHELIUM AND MUSCLE LAYERS PRESENT | ||
ON BOTH SLIDE A1-1 AND SLIDE A2-1. | |||
</pre> | |||
=====One container is empty===== | |||
<pre> | |||
A. VAS DEFERENS ("LEFT"), VASECTOMY: | |||
- VAS DEFERENS WITHIN NORMAL LIMITS, LOOPS OF EPITHELIUM AND MUSCLE LAYERS PRESENT | |||
ON BOTH SLIDE A1-1 AND SLIDE A2-1. | ON BOTH SLIDE A1-1 AND SLIDE A2-1. | ||
- SEE COMMENT. | |||
B. VAS DEFERENS ("RIGHT"), VASECTOMY: | |||
- NO TISSUE IDENTIFIED, SEE COMMENT. | |||
COMMENT: | |||
Both specimens (left vas deferens and right vas deferens) may have been placed in | |||
container A. See 'gross' section of report. Clinical correlation is essential. | |||
</pre> | </pre> | ||
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*#The words ''cross section'' imply the cut is perpendicular to the axis. | *#The words ''cross section'' imply the cut is perpendicular to the axis. | ||
*#It is possible that a section with a loop of epithelium is the result of a non-transecting cut that generates an ovoid defect in the wall of the vas deferens. | *#It is possible that a section with a loop of epithelium is the result of a non-transecting cut that generates an ovoid defect in the wall of the vas deferens. | ||
====No definite epithelium==== | |||
<pre> | |||
A. VAS DEFERENS, LEFT, VASECTOMY: | |||
- VAS DEFERENS WITHIN NORMAL LIMITS, LOOP OF EPITHELIUM AND MUSCLE LAYERS PRESENT. | |||
B. VAS DEFERENS, RIGHT, VASECTOMY: | |||
- COMPATIBLE WITH VAS DEFERENS, WITHOUT COMPLETE LOOP OF EPITHELIUM, SEE COMMENT. | |||
COMMENT - PART B: | |||
Definite vas deferens epithelium is not identified; however, the muscle layering seen is | |||
compatible with a vas deferens. Levels were cut (x4). | |||
Clinical correlation is suggested. | |||
</pre> | |||
====No vas deferens identified==== | |||
<pre> | |||
A. CONNECTIVE TISSUE, RIGHT, "VASECTOMY": | |||
- NO VAS DEFERENS IDENTIFIED. | |||
- BENIGN FIBROMUSCULAR TISSUE WITH INTERMEDIATE BLOOD VESSELS. | |||
B. CONNECTIVE TISSUE, LEFT, "VASECTOMY": | |||
- NO VAS DEFERENS IDENTIFIED. | |||
- BENIGN FIBROMUSCULAR TISSUE WITH INTERMEDIATE BLOOD VESSELS. | |||
COMMENT: | |||
Levels were cut (x3). Clinical correlation is suggested. | |||
</pre> | |||
==Vasitis nodosa== | ==Vasitis nodosa== | ||
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*[[Prostate gland]]. | *[[Prostate gland]]. | ||
*[[Testis]]. | *[[Testis]]. | ||
*[[Male infertility]]. | |||
*[[Epididymis]]. | |||
==References== | ==References== | ||