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Difference between revisions of "ALK translocation renal cell carcinoma"
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ALK translocation renal cell carcinoma (view source)
Revision as of 21:26, 26 September 2025
, 21:26, 26 September 2025→IHC
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==IHC== | ==IHC== | ||
Features:<ref>{{Cite journal | last1 = Jeanneau | first1 = M. | last2 = Gregoire | first2 = V. | last3 = Desplechain | first3 = C. | last4 = Escande | first4 = F. | last5 = Tica | first5 = DP. | last6 = Aubert | first6 = S. | last7 = Leroy | first7 = X. | title = ALK rearrangements-associated renal cell carcinoma (RCC) with unique pathological features in an adult. | journal = Pathol Res Pract | volume = 212 | issue = 11 | pages = 1064-1066 | month = Nov | year = 2016 | doi = 10.1016/j.prp.2016.07.015 | PMID = 27554841 }}</ref> | Features:<ref>{{Cite journal | last1 = Jeanneau | first1 = M. | last2 = Gregoire | first2 = V. | last3 = Desplechain | first3 = C. | last4 = Escande | first4 = F. | last5 = Tica | first5 = DP. | last6 = Aubert | first6 = S. | last7 = Leroy | first7 = X. | title = ALK rearrangements-associated renal cell carcinoma (RCC) with unique pathological features in an adult. | journal = Pathol Res Pract | volume = 212 | issue = 11 | pages = 1064-1066 | month = Nov | year = 2016 | doi = 10.1016/j.prp.2016.07.015 | PMID = 27554841 }}</ref> | ||
*ALK +ve. | *L-ALK +ve. ‡ | ||
*PAX8 +ve. | *PAX8 +ve. | ||
*Vimentin +ve (diffuse). | *Vimentin +ve (diffuse). | ||
*CK7 +ve (focal). | *CK7 +ve (focal). | ||
*[[SMARCB1]] normal nuclear staining.{{fact}} | *[[SMARCB1]] normal nuclear staining.{{fact}} | ||
‡ There are different clones for ALK. The ALK clone for lung cancer (e.g. D5F3) should be used.<ref>{{cite journal |authors=Kai K, Tobu S, Kido S, Mikami S, Takeuchi K, Dobashi A, Togashi Y, Noguchi M, Aishima S |title=ALK rearrangement-associated renal cell carcinoma morphologically mimicking mucinous tubular and spindle cell carcinoma: a case report |journal=Diagn Pathol |volume=17 |issue=1 |pages=52 |date=June 2022 |pmid=35718773 |pmc=9206751 |doi=10.1186/s13000-022-01238-z |url=}}</ref> | |||
==Molecular== | ==Molecular== | ||