Well-differentiated papillary mesothelial tumour: Difference between revisions

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| Image      = Well-differentiated_papillary_mesothelioma_--_intermed._mag.jpg
| Image      = Well-differentiated_papillary_mesothelioma_--_intermed._mag.jpg
| Width      =
| Width      =
| Caption    = Well-differentiated papillary mesothelioma. [[H&E stain]].
| Caption    = Well-differentiated papillary mesothelial tumour. [[H&E stain]].
| Synonyms  = benign papillary mesothelioma
| Synonyms  = well-differentiated papillary mesothelioma (obsolete term), benign papillary mesothelioma (obsolete term)
| Micro      = papillary structures with thick fibrous cores and simple cuboidal epithelium, lacks cytologic atypia
| Micro      = papillary structures with thick fibrous cores and simple cuboidal epithelium, lacks cytologic atypia
| Subtypes  =
| Subtypes  =
| LMDDx      = [[ovarian serous carcinoma]], [[serous borderline tumour of the ovary]], [[malignant mesothelioma]]
| LMDDx      = [[ovarian serous carcinoma]], [[serous borderline tumour of the ovary]], [[malignant mesothelioma]] especially ''papillary mesothelioma in situ''
| Stains    =
| Stains    =
| IHC        = calretinin +ve, CK5/6 +ve
| IHC        = calretinin +ve, CK5/6 +ve, BAP1 retained (normal)
| EM        =
| EM        =
| Molecular  =
| Molecular  =
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| Rads      =
| Rads      =
| Endoscopy  =
| Endoscopy  =
| Prognosis  = typical indolent
| Prognosis  = typically indolent
| Other      =
| Other      =
| ClinDDx    = [[tuberculosis]], [[carcinoma|carcinomatosis]], [[primary peritoneal serous carcinoma]], others
| ClinDDx    = [[tuberculosis]], [[carcinoma|carcinomatosis]], [[primary peritoneal serous carcinoma]], others
| Tx        =
| Tx        =
}}
}}
'''Well-differentiated papillary mesothelioma''', abbreviated '''WDPM''', is a rare type of [[mesothelioma]] that typically has an indolent behaviour.<ref name=pmid11688466>{{Cite journal | last1 = Butnor | first1 = KJ. | last2 = Sporn | first2 = TA. | last3 = Hammar | first3 = SP. | last4 = Roggli | first4 = VL. | title = Well-differentiated papillary mesothelioma. | journal = Am J Surg Pathol | volume = 25 | issue = 10 | pages = 1304-9 | month = Oct | year = 2001 | doi = | PMID = 11688466 }}</ref>
'''Well-differentiated papillary mesothelial tumour''', abbreviated '''WDPMT''', is a rare benign mesothelial tumour.<ref name=pmid35440764>{{cite journal |authors=Churg A, Galateau-Salle F |title=Well differentiated papillary mesothelial tumor: a new name and new problems |journal=Mod Pathol |volume=35 |issue=10 |pages=1327–1333 |date=October 2022 |pmid=35440764 |doi=10.1038/s41379-022-01082-y |url=}}</ref>


It is also known as '''benign papillary mesothelioma'''. It should '''not''' be confused with ''[[malignant mesothelioma]]'' or ''[[benign multicystic mesothelioma]]''.
It was previously known as ''well-differentiated papillary mesothelioma'', abbreviated ''WDPM''.<ref name=pmid35440764/><ref name=pmid11688466>{{Cite journal  | last1 = Butnor | first1 = KJ. | last2 = Sporn | first2 = TA. | last3 = Hammar | first3 = SP. | last4 = Roggli | first4 = VL. | title = Well-differentiated papillary mesothelioma. | journal = Am J Surg Pathol | volume = 25 | issue = 10 | pages = 1304-9 | month = Oct | year = 2001 | doi =  | PMID = 11688466 }}</ref>  It was also known as ''benign papillary mesothelioma''. This entity should ''not'' be confused with ''[[malignant mesothelioma]]'' and ''[[benign multicystic mesothelioma]]''.


==General==
==General==
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*[[Ovarian serous carcinoma]].
*[[Ovarian serous carcinoma]].
*[[Serous borderline tumour of the ovary]].
*[[Serous borderline tumour of the ovary]].
*[[Malignant mesothelioma]].
*[[Malignant mesothelioma]] - especially [[papillary mesothelioma in situ]].
**''Papillary mesothelioma in situ'' is morphologically identical.<ref name=pmid35440764/>


===Images===
===Images===
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*Calretinin +ve.
*Calretinin +ve.
*CK5/6 +ve.
*CK5/6 +ve.
*[[BAP1]] retained (normal).<ref name=pmid35440764/>
*MTAP retained (normal).
**May not be sensitive.{{fact}}
*[[Claudin-4]] -ve.{{fact}}
==Sign out==
<pre>
A. Submitted as "Peritoneal Deposit", Excision:
- Well-differentiated papillary mesothelial tumour, see comment.
- NEGATIVE for malignancy.
Comment:
Well-differentiated papillary mesothelial tumour is a benign tumour.
The tumour has retained (normal) BAP1 and retained MTAP staining.
Claudin-4 and NF2F are NEGATIVE.
</pre>


==See also==
==See also==
*[[Peritoneum]].
*[[Peritoneum]].
*[[Malignant mesothelioma]].
*[[Malignant mesothelioma]].
*[[Mesothelioma]].


==References==
==References==
Retrieved from "https://librepathology.org/wiki/Well-differentiated_papillary_mesothelial_tumour"