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Difference between revisions of "Malignant mesothelioma"
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Malignant mesothelioma (view source)
Revision as of 14:37, 15 September 2025
, 14:37, 15 September 2025no edit summary
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| LMDDx = mesothelial hyperplasia, [[fibrosing pleuritis]], [[adenocarcinoma]] - esp. [[lung adenocarcinoma|lung]], [[serous carcinoma]] | | LMDDx = mesothelial hyperplasia, [[fibrosing pleuritis]], [[adenocarcinoma]] - esp. [[lung adenocarcinoma|lung]], [[serous carcinoma]] | ||
| Stains = | | Stains = | ||
| IHC = calretinin +ve, D2-40 +ve, [[CK5/6]] +ve, WT-1 +ve, [[CK7]] +ve, CEA -ve, [[TTF-1]] -ve | | IHC = calretinin +ve, D2-40 +ve, [[CK5/6]] +ve, WT-1 +ve, [[CK7]] +ve, CEA -ve, [[TTF-1]] -ve, MTAP -ve (pleural mesothelioma), BAP1 -ve | ||
| EM = | | EM = | ||
| Molecular = +/-p16 deletion | | Molecular = +/-p16 deletion | ||
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'''Malignant mesothelioma''', also '''mesothelioma''', is a form of [[cancer]]. It arises from the mesothelium. | '''Malignant mesothelioma''', also '''mesothelioma''', is a form of [[cancer]]. It arises from the mesothelium. | ||
It should '''not''' be confused with ''[[benign multicystic mesothelioma]]'' and ''[[benign papillary mesothelioma | It should '''not''' be confused with ''[[benign multicystic mesothelioma]]'' and ''[[well-differentiated papillary mesothelial tumour]]'' (previously ''benign papillary mesothelioma''). | ||
==General== | ==General== | ||
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Note: | Note: | ||
*A simple pankeratin is useful for seeing where epithelial cells are. | |||
*A simple pankeratin is useful for | |||
Others: | |||
*MTAP -ve.<ref name=pmid34465883>{{cite journal |authors=Dacic S |title=Pleural mesothelioma classification-update and challenges |journal=Mod Pathol |volume=35 |issue=Suppl 1 |pages=51–56 |date=January 2022 |pmid=34465883 |doi=10.1038/s41379-021-00895-7 |url=}}</ref> | |||
**May not be sensitive and specific for peritoneal mesothelioma.{{fact}} | |||
===Mesothelioma versus adenocarcinoma=== | ===Mesothelioma versus adenocarcinoma=== | ||
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**D2-40. | **D2-40. | ||
**[[CK5/6]]. | **[[CK5/6]]. | ||
**[[CA-125]].<ref name=pmid9023557>{{cite journal |authors=Bateman AC, al-Talib RK, Newman T, Williams JH, Herbert A |title=Immunohistochemical phenotype of malignant mesothelioma: predictive value of CA125 and HBME-1 expression |journal=Histopathology |volume=30 |issue=1 |pages=49–56 |date=January 1997 |pmid=9023557 |doi=10.1046/j.1365-2559.1996.d01-562.x |url=}}</ref> | |||
*Carcinoma markers: | *Carcinoma markers: | ||
**CEA (monoclonal and polyclonal). | **CEA (monoclonal and polyclonal). | ||
**[[TTF-1]]. | **[[TTF-1]]. | ||
**[[Ber-EP4]]. | **[[Ber-EP4]]. | ||
***100% of lung adenocarcinoma versus ~25% of mesotheliomas.<ref>{{cite journal |authors=Ordóñez NG |title=Value of the Ber-EP4 antibody in differentiating epithelial pleural mesothelioma from adenocarcinoma. The M.D. Anderson experience and a critical review of the literature |journal=Am J Clin Pathol |volume=109 |issue=1 |pages=85–9 |date=January 1998 |pmid= |doi=10.1093/ajcp/109.1.85 |url=}}</ref> | |||
**MOC-31. | **MOC-31. | ||
**CD15. | **CD15. | ||
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*[[CD138]] +ve. | *[[CD138]] +ve. | ||
**Usually -ve in mesothelioma.<ref name=pmid12866374>{{Cite journal | last1 = Chu | first1 = PG. | last2 = Arber | first2 = DA. | last3 = Weiss | first3 = LM. | title = Expression of T/NK-cell and plasma cell antigens in nonhematopoietic epithelioid neoplasms. An immunohistochemical study of 447 cases. | journal = Am J Clin Pathol | volume = 120 | issue = 1 | pages = 64-70 | month = Jul | year = 2003 | doi = 10.1309/48KC-17WA-U69B-TBXQ | PMID = 12866374 }}</ref> | **Usually -ve in mesothelioma.<ref name=pmid12866374>{{Cite journal | last1 = Chu | first1 = PG. | last2 = Arber | first2 = DA. | last3 = Weiss | first3 = LM. | title = Expression of T/NK-cell and plasma cell antigens in nonhematopoietic epithelioid neoplasms. An immunohistochemical study of 447 cases. | journal = Am J Clin Pathol | volume = 120 | issue = 1 | pages = 64-70 | month = Jul | year = 2003 | doi = 10.1309/48KC-17WA-U69B-TBXQ | PMID = 12866374 }}</ref> | ||
==Molecular== | ==Molecular== | ||