Difference between revisions of "Cytogenetic tests"

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| MLL
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| ALL or AML
| ALL or AML
| ?
| rearrangment --> marker of poor prognosis<ref>{{Cite journal  | last1 = Liedtke | first1 = M. | last2 = Cleary | first2 = ML. | title = Therapeutic targeting of MLL. | journal = Blood | volume = 113 | issue = 24 | pages = 6061-8 | month = Jun | year = 2009 | doi = 10.1182/blood-2008-12-197061 | PMID = 19289854 }}
</ref>
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| MYC
| MYC

Revision as of 17:14, 12 May 2011

Thsi article is a list of common cytogenetic tests. An introduction to cytogenetics is in the cytogenetics article.

Karyotyping

Findings:

  • 5q deletion seen in myelodysplastic syndromes.[1]
  • Y deletion in MDS[2] - relatively common in old men.

ISH

Cytogenetic tests at one hospital:[3]

Test Parameters Notes
BCR/ABL1 CML or ALL Tx (imatinib)
MLL ALL or AML rearrangment --> marker of poor prognosis[4]
MYC Burkitt's lymphoma + others prognostic
ALK DLBCL - BCL6, BCL2 or MYC ?
MALT1 MALT lymphoma trisomy 3, trisomy 18
CCND1 mantle cell lymphoma ?
BCL2 follicular lymphoma
ERBB2 (HER2) breast cancer prognostic, Tx (trastuzumab)
EWSR1 small round blue cell tumour (suspected Ewing sarcoma)

See also

References

  1. Nimer, SD. (Jun 2006). "Clinical management of myelodysplastic syndromes with interstitial deletion of chromosome 5q.". J Clin Oncol 24 (16): 2576-82. doi:10.1200/JCO.2005.03.6715. PMID 16735711.
  2. Mallo, M.; Luño, E.; Sanzo, C.; Cervera, J.; Haase, D.; Schanz, J.; García-Manero, G.; Del Cañizo, C. et al. (Jan 2011). "Clinical impact of the clone size in MDS cases with monosomy 7 or 7q deletion, trisomy 8, 20q deletion and loss of Y chromosome.". Leuk Res. doi:10.1016/j.leukres.2011.01.003. PMID 21269692.
  3. Kamel-Reid, Suzanne. University Health Network / Department of Pathology. Cancer Cytogenetics & Molecular Diagnostics Laboratories. Test Requisition. August 2010.
  4. Liedtke, M.; Cleary, ML. (Jun 2009). "Therapeutic targeting of MLL.". Blood 113 (24): 6061-8. doi:10.1182/blood-2008-12-197061. PMID 19289854.