Difference between revisions of "Thoracic SMARCA4-deficient undifferentiated tumour"
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==IHC== | ==IHC== | ||
*SMARCA4 loss or strongly reduced (definitional | *SMARCA4 (BRG1) loss (~75% of cases) ''or'' strongly reduced (~25% of cases) - '''definitional'''. | ||
*AE1/AE3 -ve or focal. | *AE1/AE3 -ve or focal. | ||
*Synaptophysin +ve. | *Synaptophysin +ve. | ||
Revision as of 19:51, 21 August 2025
Thoracic SMARCA4-deficient undifferentiated tumour is poorly differentiated malignancy of the thorax.[1]
General
- It was debated whether it is carcinoma or a sarcoma.[2]
Microscopic
Features:
- Poorly differentiated malignancy.
- +/-Rhabdoid morphology.
IHC
- SMARCA4 (BRG1) loss (~75% of cases) or strongly reduced (~25% of cases) - definitional.
- AE1/AE3 -ve or focal.
- Synaptophysin +ve.
- Chromogranin -ve.
See also
References
- ↑ Shinno Y, Ohe Y (March 2024). "Thoracic SMARCA4-deficient undifferentiated tumor: current knowledge and future perspectives". Jpn J Clin Oncol 54 (3): 265–270. doi:10.1093/jjco/hyad175. PMID 38117955.
- ↑ Rekhtman N, Montecalvo J, Chang JC, Alex D, Ptashkin RN, Ai N, Sauter JL, Kezlarian B, Jungbluth A, Desmeules P, Beras A, Bishop JA, Plodkowski AJ, Gounder MM, Schoenfeld AJ, Namakydoust A, Li BT, Rudin CM, Riely GJ, Jones DR, Ladanyi M, Travis WD (February 2020). "SMARCA4-Deficient Thoracic Sarcomatoid Tumors Represent Primarily Smoking-Related Undifferentiated Carcinomas Rather Than Primary Thoracic Sarcomas". J Thorac Oncol 15 (2): 231–247. doi:10.1016/j.jtho.2019.10.023. PMC 7556987. PMID 31751681. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7556987/.