Lymphoma: Difference between revisions
Jump to navigation
Jump to search
| (4 intermediate revisions by 2 users not shown) | |||
| Line 86: | Line 86: | ||
====Histologic terms==== | ====Histologic terms==== | ||
*Lymphomas = cells look discohesive, may be difficult to differentiate from poor differentiated carcinoma. | *Lymphomas = cells look discohesive, may be difficult to differentiate from poor differentiated carcinoma. | ||
*Auer rods = | *[[Auer rods]] = [[acute myeloid leukemia]]. | ||
**Granular cytoplasmic rod (0.5-1 x4-6 micrometres). | **Granular cytoplasmic rod (0.5-1 x4-6 micrometres). | ||
**Not pathognomonic. | |||
*Reed-Sternberg cells = [[Hodgkin's lymphoma]]. | *Reed-Sternberg cells = [[Hodgkin's lymphoma]]. | ||
**Large cell - very large nucleus. | **Large cell - very large nucleus. | ||
| Line 104: | Line 105: | ||
Others: | Others: | ||
*AE1/AE3 -- to r/o carcinoma. | *[[AE1/AE3]] -ve -- to r/o carcinoma. | ||
====T cell markers==== | ====T cell markers==== | ||
| Line 326: | Line 327: | ||
Features: | Features: | ||
*Intermediate size cells with: | *Intermediate size cells with: | ||
**+/-Vesicular nuclei. | **+/-[[Vesicular nuclei]]. | ||
**Clear, moderate cytoplasm. | **Clear, moderate cytoplasm. | ||
*"Empty" sinus; subcapsular sinuses "open". | *"Empty" sinus; subcapsular sinuses "open". | ||
| Line 406: | Line 407: | ||
**''Hyperviscosity syndrome''. | **''Hyperviscosity syndrome''. | ||
**Bony destruction (seen in [[multiple myeloma]]) is absent.<ref name=Ref_PCPBoD8_325>{{Ref PCPBoD8|325}}</ref> | **Bony destruction (seen in [[multiple myeloma]]) is absent.<ref name=Ref_PCPBoD8_325>{{Ref PCPBoD8|325}}</ref> | ||
**Over 90% of patients have the MYD88 L265P somatic mutation.<ref name=pmid=22931316>{{cite journal |vauthors=Treon SP, Xu L, Yang G, Zhou Y, Liu X, Cao Y, Sheehy P, Manning RJ, Patterson CJ, Tripsas C, Arcaini L, Pinkus GS, Rodig SJ, Sohani AR, Harris NL, Laramie JM, Skifter DA, Lincoln SE, Hunter ZR |title=MYD88 L265P somatic mutation in Waldenström's macroglobulinemia |journal=N Engl J Med |volume=367 |issue=9 |pages=826–33 |date=August 2012 |pmid=22931316 |doi=10.1056/NEJMoa1200710 |url=}}</ref> | |||
====Clinical==== | ====Clinical==== | ||