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Difference between revisions of "Tumour regression"
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'''Tumour regression''' can occur as a consequence of treatment | '''Tumour regression''' can occur (1) sporadically, or (2) as a consequence of treatment (treatment response). | ||
==Sporadic tumour regression== | ==Sporadic tumour regression== | ||
| Line 6: | Line 6: | ||
*[[Malignant melanoma]]. | *[[Malignant melanoma]]. | ||
*[[Neuroblastoma]]. | *[[Neuroblastoma]]. | ||
May occur in: | |||
*[[Basal cell carcinoma]].<ref name=Ref_Derm476>{{Ref Derm|476}}</ref> | |||
Note: | |||
*Melanocytic lesions in general, ''not'' only melanoma, may regress.<ref name=Ref_Derm476>{{Ref Derm|476}}</ref><ref name=pmid21029398>{{Cite journal | last1 = Speeckaert | first1 = R. | last2 = van Geel | first2 = N. | last3 = Vermaelen | first3 = KV. | last4 = Lambert | first4 = J. | last5 = Van Gele | first5 = M. | last6 = Speeckaert | first6 = MM. | last7 = Brochez | first7 = L. | title = Immune reactions in benign and malignant melanocytic lesions: lessons for immunotherapy. | journal = Pigment Cell Melanoma Res | volume = 24 | issue = 2 | pages = 334-44 | month = Apr | year = 2011 | doi = 10.1111/j.1755-148X.2010.00799.x | PMID = 21029398 }}</ref> | |||
==Microscopic== | ==Microscopic== | ||
| Line 12: | Line 18: | ||
*+/-Mucin. | *+/-Mucin. | ||
*+/-Inflammation. | *+/-Inflammation. | ||
*+/-Histiocytes. | |||
Note: | |||
*There are specific criteria for ''[[malignant melanoma]]''. | |||
===Grading of tumour regression=== | ===Grading of tumour regression=== | ||
There is a three tiered regression grading system by Ryan ''et al''.<ref name=pmid16045774>{{Cite journal | last1 = Ryan | first1 = R. | last2 = Gibbons | first2 = D. | last3 = Hyland | first3 = JM. | last4 = Treanor | first4 = D. | last5 = White | first5 = A. | last6 = Mulcahy | first6 = HE. | last7 = O'Donoghue | first7 = DP. | last8 = Moriarty | first8 = M. | last9 = Fennelly | first9 = D. | title = Pathological response following long-course neoadjuvant chemoradiotherapy for locally advanced rectal cancer. | journal = Histopathology | volume = 47 | issue = 2 | pages = 141-6 | month = Aug | year = 2005 | doi = 10.1111/j.1365-2559.2005.02176.x | PMID = 16045774 }}</ref> | ====Colorectal carcinoma==== | ||
{{Main|Colorectal carcinoma}} | |||
There is a three tiered regression grading system by Ryan ''et al''. for [[colorectal cancer]].<ref name=pmid16045774>{{Cite journal | last1 = Ryan | first1 = R. | last2 = Gibbons | first2 = D. | last3 = Hyland | first3 = JM. | last4 = Treanor | first4 = D. | last5 = White | first5 = A. | last6 = Mulcahy | first6 = HE. | last7 = O'Donoghue | first7 = DP. | last8 = Moriarty | first8 = M. | last9 = Fennelly | first9 = D. | title = Pathological response following long-course neoadjuvant chemoradiotherapy for locally advanced rectal cancer. | journal = Histopathology | volume = 47 | issue = 2 | pages = 141-6 | month = Aug | year = 2005 | doi = 10.1111/j.1365-2559.2005.02176.x | PMID = 16045774 }}</ref> | |||
====Esophageal carcinoma==== | |||
*The three tier system from Ryan ''et al.'' for colorectal cancer has been applied to esophageal carcinomas.<ref>{{cite journal |authors=Takeda FR, Tustumi F, de Almeida Obregon C, Yogolare GG, Navarro YP, Segatelli V, Sallum RAA, Junior UR, Cecconello I |title=Prognostic Value of Tumor Regression Grade Based on Ryan Score in Squamous Cell Carcinoma and Adenocarcinoma of Esophagus |journal=Ann Surg Oncol |volume=27 |issue=4 |pages=1241–1247 |date=April 2020 |pmid=31664618 |doi=10.1245/s10434-019-07967-8 |url=}}</ref> | |||
====Ovarian carcinoma==== | |||
{{Main|Ovarian carcinoma}} | |||
This has been examined by McCluggage ''et al.''<ref name=pmid11825920>{{Cite journal | last1 = McCluggage | first1 = WG. | last2 = Lyness | first2 = RW. | last3 = Atkinson | first3 = RJ. | last4 = Dobbs | first4 = SP. | last5 = Harley | first5 = I. | last6 = McClelland | first6 = HR. | last7 = Price | first7 = JH. | title = Morphological effects of chemotherapy on ovarian carcinoma. | journal = J Clin Pathol | volume = 55 | issue = 1 | pages = 27-31 | month = Jan | year = 2002 | doi = | PMID = 11825920 }}</ref> | |||
==See also== | |||
*[[Neoadjuvant therapy]]. | |||
==References== | ==References== | ||