Adrenal cortical adenoma: Difference between revisions
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| Micro = | | Micro = | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = adrenal cortical nodule, | | LMDDx = adrenal cortical nodule, adrenal cortical hyperplasia, [[adrenal cortical carcinoma]] | ||
| Stains = | | Stains = | ||
| IHC = [[calretinin]], inhibin | | IHC = [[calretinin]], inhibin | ||
| EM = | | EM = | ||
| Molecular = | | Molecular = cortisol-producing (PRKACA, GNAS1, MENIN, ARMC5, APC, FH, PRKAR1A, PDE11A, PDE8B), aldosterone-producing (KCNJ5, ATP1A1, ATP2B3, CACNA1D, CTNNB1), non-secreting (CTNNB1) | ||
| IF = | | IF = | ||
| Gross = | | Gross = | ||
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| Clinicalhx = | | Clinicalhx = | ||
| Signs = | | Signs = | ||
| Symptoms = | | Symptoms = | ||
| Prevalence = relatively common | | Prevalence = relatively common | ||
| Bloodwork = | | Bloodwork = +/-cortisol elevation, +/-aldosterone elevation | ||
| Rads = adrenal mass, HU<10 | | Rads = adrenal mass, HU<10 | ||
| Endoscopy = | | Endoscopy = | ||
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The serology in adenoma has been associated with certain genes:<ref name=pmid30969728>{{cite journal |authors=Mahmood E, Loughner CL, Anastasopoulou C |title= |journal= |volume= |issue= |pages= |date= |pmid=30969728 |doi= |url=}}</ref> | The serology in adenoma has been associated with certain genes:<ref name=pmid30969728>{{cite journal |authors=Mahmood E, Loughner CL, Anastasopoulou C |title= |journal= |volume= |issue= |pages= |date= |pmid=30969728 |doi= |url=}}</ref> | ||
{| class="wikitable sortable" | {| class="wikitable sortable" | ||
!Serology | |||
!Gene(s) | |||
|- | |- | ||
|non-secreting adenoma | |non-secreting adenoma | ||
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None of the following are present in the cortex: | None of the following are present in the cortex: | ||
High nuclear grade, high mitotic rate (mitotic activity | High nuclear grade, high mitotic rate (mitotic activity >5/50 HPF, | ||
where 1 HPF~=0.2376 mm*mm), atypical mitoses, sheeting, necrosis, | where 1 HPF~=0.2376 mm*mm), atypical mitoses, sheeting, necrosis, | ||
sinusoidal invasion, venous invasion, capsular invasion. | sinusoidal invasion, venous invasion, capsular invasion. | ||