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Difference between revisions of "Micropapillary urothelial carcinoma"
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| Caption = Urothelial carcinoma with invasive micropapillary features. [[H&E stain]]. | | Caption = Urothelial carcinoma with invasive micropapillary features. [[H&E stain]]. | ||
| Synonyms = | | Synonyms = | ||
| Micro = nests of tumour cells with clefting to the surrounding stroma (invasive pattern) | | Micro = nests of tumour cells with clefting to the surrounding stroma (invasive pattern) ''or'' micropapillae (nipple-like structures without fibrovascular cores) | ||
| Subtypes = (subtype of [[urothelial carcinoma]]) | | Subtypes = (subtype of [[urothelial carcinoma]]) | ||
| LMDDx = conventional [[urothelial carcinoma]], other micropapillary carcinomas ([[metastases]]) | | LMDDx = conventional [[urothelial carcinoma]], other micropapillary carcinomas ([[metastases]]) | ||
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==Microscopic== | ==Microscopic== | ||
Features:<ref name=pmid21080874/> | Features - either: | ||
#Micropapillae:<ref name=pmid21080874/> | |||
#*Nipple-like structures without fibrovascular cores. | |||
#Nests of tumour cells with clefting to the surrounding stroma - this is the invasive pattern of ''micropapillary urothelial carcinoma''. | |||
*Conventional [[urothelial carcinoma]] ( | *+/-Conventional [[urothelial carcinoma]] (common). | ||
Notes: | |||
*In other organs, [[adenocarcinoma]] would be in the differential diagnosis. It should be noted that [[adenocarcinoma of the urinary bladder]] looks quite different than ''micropapillary urothelial carcinoma''. | *In other organs, [[adenocarcinoma]] would be in the differential diagnosis. It should be noted that (primary) [[adenocarcinoma of the urinary bladder]] looks quite different than ''micropapillary urothelial carcinoma''. | ||
*Quantity of micropapillary pattern (percentage) is variable.<ref name=pmid25673582/> | |||
DDx: | DDx: | ||
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==Sign out== | ==Sign out== | ||
*Report percentage of micropapillary pattern - suggested.{{fact}} | *Report percentage of micropapillary pattern - suggested.{{fact}} | ||
* | *In 2012, Amin and Epstein suggested that one distinguish between the invasive and non-invasive micropapillary pattern.<ref name=pmid22939957>{{Cite journal | last1 = Amin | first1 = A. | last2 = Epstein | first2 = JI. | title = Noninvasive micropapillary urothelial carcinoma: a clinicopathologic study of 18 cases. | journal = Hum Pathol | volume = 43 | issue = 12 | pages = 2124-8 | month = Dec | year = 2012 | doi = 10.1016/j.humpath.2012.04.013 | PMID = 22939957 }}</ref> The WHO GU Book of 2016 suggests ''not'' using the term ''micropapillary carcinoma'' if only the non-invasive pattern is present (micropapillae ''without'' (invasive) nests of tumour with clefting to the surrounding stroma).<ref name=whogu2016_90>{{Ref WHOGU2016|90}}</ref> | ||
===Microscopic in surface micropapillary change only=== | |||
<pre> | |||
The surface of the tumour shows papillae without fibrovascular cores. | |||
</pre> | |||
==See also== | ==See also== | ||