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Difference between revisions of "Hemangioblastoma"
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{{ Infobox diagnosis | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | | Name = {{PAGENAME}} | ||
| Image = | | Image = Hemangioblastoma Histology HE.jpg | ||
| Width = | | Width = | ||
| Caption = Cerebellar hemangioblastoma. | | Caption = Cerebellar hemangioblastoma. | ||
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==General== | ==General== | ||
*Usually ''cerebellar''. | *Usually ''cerebellar''. | ||
**occassionally brainstem or spinal cord. Supratentorial tumors are exceptionally rare. | |||
*Typically in adults.<ref>{{Cite journal | last1 = Kassardjian | first1 = CD. | last2 = Macdonald | first2 = RL. | last3 = Munoz | first3 = DG. | title = Hemangioblastomas in the elderly: epidemiology and clinical characteristics. | journal = J Clin Neurosci | volume = 21 | issue = 7 | pages = 1205-8 | month = Jul | year = 2014 | doi = 10.1016/j.jocn.2013.10.023 | PMID = 24629394 }}</ref> | |||
*Associated with [[von Hippel-Lindau syndrome]]. | *Associated with [[von Hippel-Lindau syndrome]]. | ||
*WHO grade I.<ref>URL: [http://www.expertconsultbook.com/expertconsult/ob/book.do?method=display&type=bookPage&decorator=none&eid=4-u1.0-B978-1-4160-4580-9..00019-8--sc0155&isbn=978-1-4160-4580-9 http://www.expertconsultbook.com/expertconsult/ob/book.do?method=display&type=bookPage&decorator=none&eid=4-u1.0-B978-1-4160-4580-9..00019-8--sc0155&isbn=978-1-4160-4580-9]. Accessed on: 9 December 2010.</ref> | *Symptomatic when CSF flow is impaired. | ||
*WHO grade I (ICD-O: 9161/1).<ref>URL: [http://www.expertconsultbook.com/expertconsult/ob/book.do?method=display&type=bookPage&decorator=none&eid=4-u1.0-B978-1-4160-4580-9..00019-8--sc0155&isbn=978-1-4160-4580-9 http://www.expertconsultbook.com/expertconsult/ob/book.do?method=display&type=bookPage&decorator=none&eid=4-u1.0-B978-1-4160-4580-9..00019-8--sc0155&isbn=978-1-4160-4580-9]. Accessed on: 9 December 2010.</ref> | |||
==Macroscopy== | |||
*Red to yellow nodules, highly vascularized. | |||
*75% are cystic tumors. | |||
**Peripheral solid portion. | |||
==Microscopic== | ==Microscopic== | ||
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**Hyperchromatic nuclei. | **Hyperchromatic nuclei. | ||
**Vacuolar cytoplasm. | **Vacuolar cytoplasm. | ||
*Occassionally extensive sclerosis. | |||
Note: | |||
*Based on the stromal content, some classify the tumors as "cellular" and "reticular".<ref>{{Cite journal | last1 = Hasselblatt | first1 = M. | last2 = Jeibmann | first2 = A. | last3 = Gerss | first3 = J. | last4 = Behrens | first4 = C. | last5 = Rama | first5 = B. | last6 = Wassmann | first6 = H. | last7 = Paulus | first7 = W. | title = Cellular and reticular variants of haemangioblastoma revisited: a clinicopathologic study of 88 cases. | journal = Neuropathol Appl Neurobiol | volume = 31 | issue = 6 | pages = 618-22 | month = Dec | year = 2005 | doi = 10.1111/j.1365-2990.2005.00669.x | PMID = 16281910 }}</ref> | |||
DDx: | DDx: | ||
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Image:Cerebellar_hemangioblastoma_high_mag.jpg | Hemangioblastoma - high mag. (WC) | Image:Cerebellar_hemangioblastoma_high_mag.jpg | Hemangioblastoma - high mag. (WC) | ||
Image:Hemangioblastoma_-_nse_-_intermed_mag.jpg | Hemangioblastoma - NSE - intermed. mag. (WC) | Image:Hemangioblastoma_-_nse_-_intermed_mag.jpg | Hemangioblastoma - NSE - intermed. mag. (WC) | ||
File:Hemangioblastoma - nse - high mag.jpg | Hemangioblastoma - NSE - high mag. (WC) | |||
File:Hemangioblastoma Histology CD31.jpg | Hemangioblastoma - CD31. (WC/marvin101) | |||
File:Hippel Lindau.gif | Hemangioblastomas in Hippel-Lindau disease (PlosONE). | |||
</gallery> | </gallery> | ||
www: | www: | ||
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*NSE +ve (nucleus + cytoplasm). | *NSE +ve (nucleus + cytoplasm). | ||
**RCC typically -ve. | **RCC typically -ve. | ||
*CK -ve. | |||
==See also== | ==See also== | ||
*[[Von Hippel-Lindau disease]]. | *[[Von Hippel-Lindau disease]]. | ||
*[[Neuropathology tumours]]. | *[[Neuropathology tumours]]. | ||
*[[Hemangioblastoma of the kidney]]. | |||
==References== | ==References== | ||