49,006
edits
Difference between revisions of "Thymoma"
Jump to navigation
Jump to search
→Microscopic
| (8 intermediate revisions by 2 users not shown) | |||
| Line 13: | Line 13: | ||
| Molecular = | | Molecular = | ||
| IF = | | IF = | ||
| Gross = | | Gross = light brown/tan, usually encapsulated | ||
| Grossing = | | Grossing = | ||
| Staging = [[thymus staging]] | | Staging = [[thymus staging]] | ||
| Line 82: | Line 82: | ||
Image: | Image: | ||
*[http://www.sciencephoto.com/media/253251/enlarge Thymoma (sciencephoto.com)]. | *[http://www.sciencephoto.com/media/253251/enlarge Thymoma (sciencephoto.com)]. | ||
Note: | |||
*The line between ''thymoma'' and ''persistent normal thymus in the adult'' is not well-defined in the radiologic context.<ref name=pmid25925358>{{Cite journal | last1 = Araki | first1 = T. | last2 = Nishino | first2 = M. | last3 = Gao | first3 = W. | last4 = Dupuis | first4 = J. | last5 = Hunninghake | first5 = GM. | last6 = Murakami | first6 = T. | last7 = Washko | first7 = GR. | last8 = O'Connor | first8 = GT. | last9 = Hatabu | first9 = H. | title = Normal thymus in adults: appearance on CT and associations with age, sex, BMI and smoking. | journal = Eur Radiol | volume = 26 | issue = 1 | pages = 15-24 | month = Jan | year = 2016 | doi = 10.1007/s00330-015-3796-y | PMID = 25925358 }}</ref> | |||
==Microscopic== | ==Microscopic== | ||
| Line 89: | Line 92: | ||
**Spindle cells - Type A. | **Spindle cells - Type A. | ||
**Epithelioid cells - Type B. | **Epithelioid cells - Type B. | ||
Notes: | |||
*Perivascular edema is typical of thymoma. | |||
DDx: | DDx: | ||
| Line 94: | Line 100: | ||
*[[Lymphoma]]. | *[[Lymphoma]]. | ||
*[[Follicular dendritic cell sarcoma]]. | *[[Follicular dendritic cell sarcoma]]. | ||
*Normal persistent [[thymus]]. | |||
===Images=== | ===Images=== | ||
| Line 101: | Line 108: | ||
Image:Thymoma_B1_(3)_CK_CAM5-2.JPG | Thymoma Type B1 - CAM5.2. (WC/KGH) | Image:Thymoma_B1_(3)_CK_CAM5-2.JPG | Thymoma Type B1 - CAM5.2. (WC/KGH) | ||
</gallery> | </gallery> | ||
====Case 1==== | |||
<gallery> | <gallery> | ||
Image: Thymoma type B1 -- low mag.jpg | Thymoma B1 - low mag. | Image: Thymoma type B1 -- low mag.jpg | Thymoma B1 - low mag. | ||
| Line 108: | Line 116: | ||
Image: Thymoma type B1 - alt -- very high mag.jpg | Thymoma B1 - very high mag. | Image: Thymoma type B1 - alt -- very high mag.jpg | Thymoma B1 - very high mag. | ||
</gallery> | </gallery> | ||
====Case 2==== | |||
<gallery> | |||
File:5 404717367 sl 1.png|Thymoma type B1 | |||
File:5 404717367 sl 2.png|Thymoma type B1 | |||
File:5 404717367 sl 3.png|Thymoma type B1 | |||
File:5 404717367 sl 4.png|Thymoma type B1 | |||
File:5 404717367 sl 5.png|Thymoma type B1 | |||
File:5 404717367 sl 6.png|Thymoma type B1 | |||
</gallery> | |||
Thymoma type B1 in a 33 y man, 384 gram 9 x 10 x 8 cm. A. Blue tumor shows a starry sky pattern (red square), as well as occasional fibrous bands (red arrows). B. Epithelial component, impossible to see on H&E at lower power, is readily identified, here with immunostain for CK7. C. CK7 positivity favors B over type A. Note that where the nuclei are visible the tumor cells are round, proving type B. The predominance of lymphoid cells makes this tumor B1. D. Lymphoid cells are uniform and small. Arrows show the tangible body macrophages that gave the low power starry sky appearance. E. Lymphoid cells are CD5 positive. F. Lymphoid cells are TdT positive. | |||
====Case 3==== | |||
<gallery> | |||
Image: Thymoma type B2 -- low mag.jpg | Thymoma type B2 - low mag. | |||
Image: Thymoma type B2 -- intermed mag.jpg | Thymoma type B2 - intermed. mag. | |||
Image: Thymoma type B2 -- high mag.jpg | Thymoma type B2 - high mag. | |||
Image: Thymoma type B2 -- very high mag.jpg | Thymoma type B2 - very high mag. | |||
</gallery> | |||
===Staging=== | ===Staging=== | ||
{{Main|Thymic staging}} | {{Main|Thymic staging}} | ||
| Line 119: | Line 146: | ||
A panel: | A panel: | ||
*TdT, CD1a, CD3, CD5, CD20, Ki-67, CD117, p63, CK5/6. | *TdT, CD1a, CD3, CD5, CD20, Ki-67, CD117, [[p63]], [[CK5/6]]. | ||
==Sign out== | ==Sign out== | ||
| Line 136: | Line 163: | ||
==See also== | ==See also== | ||
*[[Thymus]]. | *[[Thymus]]. | ||
*[[Thymus staging]]. | |||
==References== | ==References== | ||