Spermatocytic tumour: Difference between revisions
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| Caption = Spermatocytic tumour | | Caption = Spermatocytic tumour | ||
| Synonyms = spermatocytic seminoma (old term) | | Synonyms = spermatocytic seminoma (old term, not recommended by World Health Organization) | ||
| Micro = three cell populations: (1) small cells (6-8 µm) - with a large NC ratio, (2) medium cells (15-18 µm) with prominent nucleoli and spireme chromatin, (3) Large cells (50-100 µm) with spireme chromatin; mucoid lakes, intratubular spread | | Micro = three cell populations: (1) small cells (6-8 µm) - with a large NC ratio, (2) medium cells (15-18 µm) with prominent nucleoli and spireme chromatin, (3) Large cells (50-100 µm) with spireme chromatin; mucoid lakes, intratubular spread | ||
| Subtypes = | | Subtypes = | ||
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The tumour stains as follows: | The tumour stains as follows: | ||
POSITIVE: CD117 (moderate, patchy), SALL4 (moderate, diffuse | POSITIVE: CD117 (moderate, patchy), SALL4 (moderate, diffuse), BCL2 (scattered cells, moderate membranous). | ||
NEGATIVE: AE1/AE3, AFP, CD31, CD34, calretinin, hCG, CD3, CD10, CD20, CD30, CD45, GATA3, PLAP, PSA, OCT3/4. | NEGATIVE: AE1/AE3, AFP, CD31, CD34, calretinin, hCG, CD3, CD10, CD20, CD30, CD45, GATA3, PLAP, PSA, OCT3/4, CAM5.2, D2-40. | ||
This tumour (spermatoctyic tumour) was previously known as "spermatocytic seminoma". The term "spermatocytic seminoma" is no longer recommended by the | This tumour (spermatoctyic tumour) was previously known as "spermatocytic seminoma". The term "spermatocytic seminoma" is no longer recommended by the World Health Organization, presumably as the name may: (1) create confusion with "seminoma" and (2) falsely raise the possibility of a mixed tumour (that develops in the context of GCNIS). | ||
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