Spermatocytic tumour: Difference between revisions

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| Image      = Spermatocytic_seminoma_high_mag.jpg
| Image      = Spermatocytic_seminoma_high_mag.jpg
| Width      =
| Width      =
| Caption    = Spermatocytic seminoma
| Caption    = Spermatocytic tumour
| Micro      = three cell sizes: (1) small cells (6-8 µm) - with a large NC ratio, (2) medium cells (15-18 µm) with prominent nucleoli and spireme chromatin, (3) Large cells (50-100 µm) with spireme chromatin; mucoid lakes, intratubular spread
| Synonyms  = spermatocytic seminoma (old term, not recommended by World Health Organization)
| Micro      = three cell populations: (1) small cells (6-8 µm) - with a large NC ratio, (2) medium cells (15-18 µm) with prominent nucleoli and spireme chromatin, (3) Large cells (50-100 µm) with spireme chromatin; mucoid lakes, intratubular spread
| Subtypes  =
| Subtypes  =
| LMDDx      = [[DLBCL]], [[seminoma]]
| LMDDx      = [[DLBCL]], [[seminoma]]
| Stains    =
| Stains    =
| IHC        =
| IHC        = SALL4 +ve, OCT3/4 -ve, CD117 +ve/-ve
| EM        =
| EM        =
| Molecular  =
| Molecular  =
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| Signs      = mass lesion
| Signs      = mass lesion
| Symptoms  =
| Symptoms  =
| Prevalence =
| Prevalence = rare
| Bloodwork  =
| Bloodwork  =
| Rads      =
| Rads      =
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| Other      =
| Other      =
| ClinDDx    = other [[germ cell tumours]], [[lymphoma]]
| ClinDDx    = other [[germ cell tumours]], [[lymphoma]]
| Tx        = excision to exclude malignancy
}}
}}
'''Spermatocytic_seminoma''' is a rare benign testicular tumour.
'''Spermatocytic tumour''' is a rare benign testicular tumour.
 
It was previously known as '''spermatocytic seminoma'''. It should ''not'' be confused with [[seminoma]] which is an unrelated tumour.


==General==
==General==
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===Epidemiology===
===Epidemiology===
*Does NOT arise from ''[[intratubular germ cell neoplasia]]'' (ITGCN)<ref>{{cite journal |author=Müller J, Skakkebaek NE, Parkinson MC |title=The spermatocytic seminoma: views on pathogenesis |journal=Int. J. Androl. |volume=10 |issue=1 |pages=147–56 |year=1987 |month=February |pmid=3583416 |doi= 10.1111/j.1365-2605.1987.tb00176.x|url=}}</ref> - '''not''' considered a subtype of [[seminoma]].
*Does ''not'' arise from ''[[germ cell neoplasia in situ]]'' (previously known as ''intratubular germ cell neoplasia'')<ref name=pmid3583416>{{cite journal |author=Müller J, Skakkebaek NE, Parkinson MC |title=The spermatocytic seminoma: views on pathogenesis |journal=Int. J. Androl. |volume=10 |issue=1 |pages=147–56 |year=1987 |month=February |pmid=3583416 |doi= 10.1111/j.1365-2605.1987.tb00176.x|url=}}</ref> - '''not''' considered a subtype of [[seminoma]].


==Microscopic==
==Microscopic==
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===Images===
===Images===
<gallery>
<gallery>
Image:Spermatocytic_seminoma_high_mag.jpg | Spermatocytic seminoma - high mag. (WC)
Image:Spermatocytic_seminoma_high_mag.jpg | Spermatocytic tumour - high mag. (WC)
Image:Spermatocytic_seminoma_intermed_mag.jpg | Spermatocytic seminoma - intermed. mag. (WC)
Image:Spermatocytic_seminoma_intermed_mag.jpg | Spermatocytic tumour - intermed. mag. (WC)
Image:testicular spermatocytic tumour high mag.jpg | Spermatocytic tumour - high mag. (WC)
</gallery>
</gallery>
==IHC==
==IHC==
Features:<ref name=pmid10223302>{{Cite journal  | last1 = Kraggerud | first1 = SM. | last2 = Berner | first2 = A. | last3 = Bryne | first3 = M. | last4 = Pettersen | first4 = EO. | last5 = Fossa | first5 = SD. | title = Spermatocytic seminoma as compared to classical seminoma: an immunohistochemical and DNA flow cytometric study. | journal = APMIS | volume = 107 | issue = 3 | pages = 297-302 | month = Mar | year = 1999 | doi =  | PMID = 10223302 }}</ref>
Features:<ref name=pmid10223302>{{Cite journal  | last1 = Kraggerud | first1 = SM. | last2 = Berner | first2 = A. | last3 = Bryne | first3 = M. | last4 = Pettersen | first4 = EO. | last5 = Fossa | first5 = SD. | title = Spermatocytic seminoma as compared to classical seminoma: an immunohistochemical and DNA flow cytometric study. | journal = APMIS | volume = 107 | issue = 3 | pages = 297-302 | month = Mar | year = 1999 | doi =  | PMID = 10223302 }}</ref>
*PLAP -ve (0 positive/17).
*[[PLAP]] -ve (0 positive/17).
*CD117 -ve (7 positive/17).
*CD117 -ve (7 positive/17).
*CAM5.2 -ve (1 positive/17).
*CAM5.2 -ve (1 positive/17).
Others:<ref>{{Ref WHOGU2022|289}}</ref>
*SALL4 +ve.
*OCT3/4 -ve.
*AFP -ve.
*CD30 -ve.
*Beta-hCG -ve.
==Sign out==
<pre>
Left Testis, Radical Orchiectomy:
- Spermatocytic tumour, see comment.
- NEGATIVE for germ cell neoplasia in situ.
- Background testis with spermatogenesis and atrophy.
Comment:
Spermatocytic tumours are rare. They are not associated with germ cell neoplasia in situ (GCNIS) and typically not seen together with other germ cell types. 
The tumour stains as follows:
POSITIVE: CD117 (moderate, patchy), SALL4 (moderate, diffuse), BCL2 (scattered cells, moderate membranous).
NEGATIVE: AE1/AE3, AFP, CD31, CD34, calretinin, hCG, CD3, CD10, CD20, CD30, CD45, GATA3, PLAP, PSA, OCT3/4, CAM5.2, D2-40.
This tumour (spermatoctyic tumour) was previously known as "spermatocytic seminoma".  The term "spermatocytic seminoma" is no longer recommended by the World Health Organization, presumably as the name may: (1) create confusion with "seminoma" and (2) falsely raise the possibility of a mixed tumour (that develops in the context of GCNIS).
</pre>
===Micro===
This tumour has three cell types with spireme chromatin in the larger and intermediate cell type. Infiltrating lymphocytes are absent.
The background testis has some spermatogenesis and atrophic change. Germ cell neoplasia in situ (GCNIS) is ABSENT.  The seminiferous tubules adjacent to the tumour, where visualized, are atrophic.


==See also==
==See also==
Retrieved from "https://librepathology.org/wiki/Spermatocytic_tumour"