Difference between revisions of "Serous tubal intraepithelial carcinoma"

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Serous tubal intraepithelial carcinoma (view source)

Revision as of 05:17, 4 November 2024

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| Assdx      =
| Assdx      =
| Syndromes  =
| Syndromes  =
| Clinicalhx = BRCA mutation carrier
| Clinicalhx =  
| Signs      =  
| Signs      =  
| Symptoms  = none
| Symptoms  = none
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DDx:
DDx:
*Atypical tubal lesion (STIL or TILT) - lack proliferation.{{fact}}
*Atypical tubal lesion (STIL or ''tubal intraepithelial lesions in transition'' (TILT)<ref>{{cite journal |authors=Nishida N, Murakami F, Higaki K |title=Detection of serous precursor lesions in resected fallopian tubes from patients with benign diseases and a relatively low risk for ovarian cancer |journal=Pathol Int |volume=66 |issue=6 |pages=337–42 |date=June 2016 |pmid=27250113 |doi=10.1111/pin.12419 |url=}}</ref>) - lack proliferation.{{fact}}
*[[Serous carcinoma of the fallopian tube]].


===Images===
===Images===
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Image: Serous tubal intraepithelial carcinoma - alt -- high mag.jpg | STIC - high mag. (WC)
Image: Serous tubal intraepithelial carcinoma - alt -- high mag.jpg | STIC - high mag. (WC)
Image: Serous tubal intraepithelial carcinoma -- very high mag.jpg | STIC - very high mag. (WC)
Image: Serous tubal intraepithelial carcinoma -- very high mag.jpg | STIC - very high mag. (WC)
</gallery>
====www====
*[http://www.nature.com/modpathol/journal/v23/n6/fig_tab/modpathol201060f1.html#figure-title STIC (nature.com)].<ref name=pmid20228782>{{Cite journal  | last1 = Sehdev | first1 = AS. | last2 = Kurman | first2 = RJ. | last3 = Kuhn | first3 = E. | last4 = Shih | first4 = IeM. | title = Serous tubal intraepithelial carcinoma upregulates markers associated with high-grade serous carcinomas including Rsf-1 (HBXAP), cyclin E and fatty acid synthase. | journal = Mod Pathol | volume = 23 | issue = 6 | pages = 844-55 | month = Jun | year = 2010 | doi = 10.1038/modpathol.2010.60 | PMID = 20228782 }}</ref>
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3148026/figure/F3/ STIC - schematic (nih.gov)].<ref name=pmid21683865>{{Cite journal  | last1 = Kurman | first1 = RJ. | last2 = Shih | first2 = IeM. | title = Molecular pathogenesis and extraovarian origin of epithelial ovarian cancer--shifting the paradigm. | journal = Hum Pathol | volume = 42 | issue = 7 | pages = 918-31 | month = Jul | year = 2011 | doi = 10.1016/j.humpath.2011.03.003 | PMID = 21683865 }}</ref>
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3148026/figure/F6/ STIC and STIL with p53 stain (nih.gov)].<ref name=pmid21683865/>
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3148026/figure/F5/ STIC - p53 stain (nih.gov)].<ref name=pmid21683865/>
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2860809/figure/fig1/ Small STIC - H&E and p53 (nih.gov)].<ref name=pmid20445756>{{Cite journal  | last1 = Gross | first1 = AL. | last2 = Kurman | first2 = RJ. | last3 = Vang | first3 = R. | last4 = Shih | first4 = IeM. | last5 = Visvanathan | first5 = K. | title = Precursor lesions of high-grade serous ovarian carcinoma: morphological and molecular characteristics. | journal = J Oncol | volume = 2010 | issue =  | pages = 126295 | month =  | year = 2010 | doi = 10.1155/2010/126295 | PMID = 20445756 }}</ref>
*[http://www.ovariancancerprevention.org/wp-content/uploads/2010/10/apotosis-and-mitosis-in-STIC.jpg  STIC - high mag. (ovariancancerprevention.org)].<ref>URL: [http://www.ovariancancerprevention.org/?page_id=191 http://www.ovariancancerprevention.org/?page_id=191]. Accessed on: 13 May 2014.</ref>
*[http://www.ovariancancerprevention.org/wp-content/uploads/2010/10/STIC-junction-HM.jpg STIC & benign - high mag. (ovariancancerprevention.org)].
==IHC==
Features:<ref name=pmid21989347/>
*p53 +ve.
*Ki-67 increased ~10%. (???)
*p16 +ve.<ref name=pmid20228782/>


===Images===
<gallery>
Image: Serous tubal intraepithelial carcinoma - p16 -- very low mag.jpg | STIC - p16 - very low mag. (WC)
Image: Serous tubal intraepithelial carcinoma - p16 -- very low mag.jpg | STIC - p16 - very low mag. (WC)
Image: Serous tubal intraepithelial carcinoma - p16 -- low mag.jpg | STIC - p16 - low mag. (WC)
Image: Serous tubal intraepithelial carcinoma - p16 -- low mag.jpg | STIC - p16 - low mag. (WC)
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Image: Serous tubal intraepithelial carcinoma - Ki-67  -- high mag.jpg | STIC - Ki-67 - high mag. (WC)
Image: Serous tubal intraepithelial carcinoma - Ki-67  -- high mag.jpg | STIC - Ki-67 - high mag. (WC)
</gallery>
</gallery>
====www====
*[http://www.nature.com/modpathol/journal/v23/n6/fig_tab/modpathol201060f1.html#figure-title STIC (nature.com)].<ref name=pmid20228782>{{Cite journal  | last1 = Sehdev | first1 = AS. | last2 = Kurman | first2 = RJ. | last3 = Kuhn | first3 = E. | last4 = Shih | first4 = IeM. | title = Serous tubal intraepithelial carcinoma upregulates markers associated with high-grade serous carcinomas including Rsf-1 (HBXAP), cyclin E and fatty acid synthase. | journal = Mod Pathol | volume = 23 | issue = 6 | pages = 844-55 | month = Jun | year = 2010 | doi = 10.1038/modpathol.2010.60 | PMID = 20228782 }}</ref>
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3148026/figure/F3/ STIC - schematic (nih.gov)].<ref name=pmid21683865>{{Cite journal  | last1 = Kurman | first1 = RJ. | last2 = Shih | first2 = IeM. | title = Molecular pathogenesis and extraovarian origin of epithelial ovarian cancer--shifting the paradigm. | journal = Hum Pathol | volume = 42 | issue = 7 | pages = 918-31 | month = Jul | year = 2011 | doi = 10.1016/j.humpath.2011.03.003 | PMID = 21683865 }}</ref>
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3148026/figure/F6/ STIC and STIL with p53 stain (nih.gov)].<ref name=pmid21683865/>
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3148026/figure/F5/ STIC - p53 stain (nih.gov)].<ref name=pmid21683865/>
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2860809/figure/fig1/ Small STIC - H&E and p53 (nih.gov)].<ref name=pmid20445756>{{Cite journal  | last1 = Gross | first1 = AL. | last2 = Kurman | first2 = RJ. | last3 = Vang | first3 = R. | last4 = Shih | first4 = IeM. | last5 = Visvanathan | first5 = K. | title = Precursor lesions of high-grade serous ovarian carcinoma: morphological and molecular characteristics. | journal = J Oncol | volume = 2010 | issue =  | pages = 126295 | month =  | year = 2010 | doi = 10.1155/2010/126295 | PMID = 20445756 }}</ref>
*[http://www.ovariancancerprevention.org/wp-content/uploads/2010/10/apotosis-and-mitosis-in-STIC.jpg  STIC - high mag. (ovariancancerprevention.org)].<ref>URL: [http://www.ovariancancerprevention.org/?page_id=191 http://www.ovariancancerprevention.org/?page_id=191]. Accessed on: 13 May 2014.</ref>
*[http://www.ovariancancerprevention.org/wp-content/uploads/2010/10/STIC-junction-HM.jpg STIC & benign - high mag. (ovariancancerprevention.org)].
==IHC==
Features:<ref name=pmid21989347/>
*p53 +ve.
*Ki-67 increased ~10%. (???)
*p16 +ve.<ref name=pmid20228782/>


==See also==
==See also==
Michael
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