Difference between revisions of "Serous tubal intraepithelial carcinoma"

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{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      = Serous tubal intraepithelial carcinoma -- low mag.jpg
| Width      =
| Caption    = Micrograph showing serous tubal intraepithelial carcinoma. [[H&E stain]].
| Synonyms  =
| Micro      = three of the following five: (1) atypical chromatin pattern, (2) nuclear enlargement, (3) nuclear pleomorphism, (4) nuclear moulding, (5) loss of nuclear polarity ''or'' epithelial stratification
| Subtypes  =
| LMDDx      =
| Stains    =
| IHC        = p16 +ve, p53 +ve, Ki-67 increased
| EM        =
| Molecular  = BRCA1 mutation or BRCA2 mutation
| IF        =
| Gross      = not apparent on gross
| Grossing  =
| Staging    =
| Site      = [[fallopian tubes]]
| Assdx      =
| Syndromes  =
| Clinicalhx =
| Signs      =
| Symptoms  = none
| Prevalence = uncommon
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  =
| Other      =
| ClinDDx    =
| Tx        =
}}
'''Serous tubal intraepithelial carcinoma''', abbreviated '''STIC'''<ref name=pmid21989347>{{Cite journal  | last1 = Visvanathan | first1 = K. | last2 = Vang | first2 = R. | last3 = Shaw | first3 = P. | last4 = Gross | first4 = A. | last5 = Soslow | first5 = R. | last6 = Parkash | first6 = V. | last7 = Shih | first7 = IeM. | last8 = Kurman | first8 = RJ. | title = Diagnosis of serous tubal intraepithelial carcinoma based on morphologic and immunohistochemical features: a reproducibility study. | journal = Am J Surg Pathol | volume = 35 | issue = 12 | pages = 1766-75 | month = Dec | year = 2011 | doi = 10.1097/PAS.0b013e31822f58bc | PMID = 21989347 }}</ref> (pronounced ''stick''), is considered to be the precursor of [[serous carcinoma]].
'''Serous tubal intraepithelial carcinoma''', abbreviated '''STIC'''<ref name=pmid21989347>{{Cite journal  | last1 = Visvanathan | first1 = K. | last2 = Vang | first2 = R. | last3 = Shaw | first3 = P. | last4 = Gross | first4 = A. | last5 = Soslow | first5 = R. | last6 = Parkash | first6 = V. | last7 = Shih | first7 = IeM. | last8 = Kurman | first8 = RJ. | title = Diagnosis of serous tubal intraepithelial carcinoma based on morphologic and immunohistochemical features: a reproducibility study. | journal = Am J Surg Pathol | volume = 35 | issue = 12 | pages = 1766-75 | month = Dec | year = 2011 | doi = 10.1097/PAS.0b013e31822f58bc | PMID = 21989347 }}</ref> (pronounced ''stick''), is considered to be the precursor of [[serous carcinoma]].


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DDx:
DDx:
*Atypical tubal lesion (STIL or TILT) - lack proliferation.{{fact}}
*Atypical tubal lesion (STIL or ''tubal intraepithelial lesions in transition'' (TILT)<ref>{{cite journal |authors=Nishida N, Murakami F, Higaki K |title=Detection of serous precursor lesions in resected fallopian tubes from patients with benign diseases and a relatively low risk for ovarian cancer |journal=Pathol Int |volume=66 |issue=6 |pages=337–42 |date=June 2016 |pmid=27250113 |doi=10.1111/pin.12419 |url=}}</ref>) - lack proliferation.{{fact}}
*[[Serous carcinoma of the fallopian tube]].


===Images===
===Images===
Line 38: Line 71:
Image: Serous tubal intraepithelial carcinoma - alt -- high mag.jpg | STIC - high mag. (WC)
Image: Serous tubal intraepithelial carcinoma - alt -- high mag.jpg | STIC - high mag. (WC)
Image: Serous tubal intraepithelial carcinoma -- very high mag.jpg | STIC - very high mag. (WC)
Image: Serous tubal intraepithelial carcinoma -- very high mag.jpg | STIC - very high mag. (WC)
</gallery>
====www====
*[http://www.nature.com/modpathol/journal/v23/n6/fig_tab/modpathol201060f1.html#figure-title STIC (nature.com)].<ref name=pmid20228782>{{Cite journal  | last1 = Sehdev | first1 = AS. | last2 = Kurman | first2 = RJ. | last3 = Kuhn | first3 = E. | last4 = Shih | first4 = IeM. | title = Serous tubal intraepithelial carcinoma upregulates markers associated with high-grade serous carcinomas including Rsf-1 (HBXAP), cyclin E and fatty acid synthase. | journal = Mod Pathol | volume = 23 | issue = 6 | pages = 844-55 | month = Jun | year = 2010 | doi = 10.1038/modpathol.2010.60 | PMID = 20228782 }}</ref>
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3148026/figure/F3/ STIC - schematic (nih.gov)].<ref name=pmid21683865>{{Cite journal  | last1 = Kurman | first1 = RJ. | last2 = Shih | first2 = IeM. | title = Molecular pathogenesis and extraovarian origin of epithelial ovarian cancer--shifting the paradigm. | journal = Hum Pathol | volume = 42 | issue = 7 | pages = 918-31 | month = Jul | year = 2011 | doi = 10.1016/j.humpath.2011.03.003 | PMID = 21683865 }}</ref>
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3148026/figure/F6/ STIC and STIL with p53 stain (nih.gov)].<ref name=pmid21683865/>
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3148026/figure/F5/ STIC - p53 stain (nih.gov)].<ref name=pmid21683865/>
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2860809/figure/fig1/ Small STIC - H&E and p53 (nih.gov)].<ref name=pmid20445756>{{Cite journal  | last1 = Gross | first1 = AL. | last2 = Kurman | first2 = RJ. | last3 = Vang | first3 = R. | last4 = Shih | first4 = IeM. | last5 = Visvanathan | first5 = K. | title = Precursor lesions of high-grade serous ovarian carcinoma: morphological and molecular characteristics. | journal = J Oncol | volume = 2010 | issue =  | pages = 126295 | month =  | year = 2010 | doi = 10.1155/2010/126295 | PMID = 20445756 }}</ref>
*[http://www.ovariancancerprevention.org/wp-content/uploads/2010/10/apotosis-and-mitosis-in-STIC.jpg  STIC - high mag. (ovariancancerprevention.org)].<ref>URL: [http://www.ovariancancerprevention.org/?page_id=191 http://www.ovariancancerprevention.org/?page_id=191]. Accessed on: 13 May 2014.</ref>
*[http://www.ovariancancerprevention.org/wp-content/uploads/2010/10/STIC-junction-HM.jpg STIC & benign - high mag. (ovariancancerprevention.org)].
==IHC==
Features:<ref name=pmid21989347/>
*p53 +ve.
*Ki-67 increased ~10%. (???)
*p16 +ve.<ref name=pmid20228782/>


===Images===
<gallery>
Image: Serous tubal intraepithelial carcinoma - p16 -- very low mag.jpg | STIC - p16 - very low mag. (WC)
Image: Serous tubal intraepithelial carcinoma - p16 -- very low mag.jpg | STIC - p16 - very low mag. (WC)
Image: Serous tubal intraepithelial carcinoma - p16 -- low mag.jpg | STIC - p16 - low mag. (WC)
Image: Serous tubal intraepithelial carcinoma - p16 -- low mag.jpg | STIC - p16 - low mag. (WC)
Line 53: Line 103:
Image: Serous tubal intraepithelial carcinoma - Ki-67  -- high mag.jpg | STIC - Ki-67 - high mag. (WC)
Image: Serous tubal intraepithelial carcinoma - Ki-67  -- high mag.jpg | STIC - Ki-67 - high mag. (WC)
</gallery>
</gallery>
====www====
*[http://www.nature.com/modpathol/journal/v23/n6/fig_tab/modpathol201060f1.html#figure-title STIC (nature.com)].<ref name=pmid20228782>{{Cite journal  | last1 = Sehdev | first1 = AS. | last2 = Kurman | first2 = RJ. | last3 = Kuhn | first3 = E. | last4 = Shih | first4 = IeM. | title = Serous tubal intraepithelial carcinoma upregulates markers associated with high-grade serous carcinomas including Rsf-1 (HBXAP), cyclin E and fatty acid synthase. | journal = Mod Pathol | volume = 23 | issue = 6 | pages = 844-55 | month = Jun | year = 2010 | doi = 10.1038/modpathol.2010.60 | PMID = 20228782 }}</ref>
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3148026/figure/F3/ STIC - schematic (nih.gov)].<ref name=pmid21683865>{{Cite journal  | last1 = Kurman | first1 = RJ. | last2 = Shih | first2 = IeM. | title = Molecular pathogenesis and extraovarian origin of epithelial ovarian cancer--shifting the paradigm. | journal = Hum Pathol | volume = 42 | issue = 7 | pages = 918-31 | month = Jul | year = 2011 | doi = 10.1016/j.humpath.2011.03.003 | PMID = 21683865 }}</ref>
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3148026/figure/F6/ STIC and STIL with p53 stain (nih.gov)].<ref name=pmid21683865/>
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3148026/figure/F5/ STIC - p53 stain (nih.gov)].<ref name=pmid21683865/>
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2860809/figure/fig1/ Small STIC - H&E and p53 (nih.gov)].<ref name=pmid20445756>{{Cite journal  | last1 = Gross | first1 = AL. | last2 = Kurman | first2 = RJ. | last3 = Vang | first3 = R. | last4 = Shih | first4 = IeM. | last5 = Visvanathan | first5 = K. | title = Precursor lesions of high-grade serous ovarian carcinoma: morphological and molecular characteristics. | journal = J Oncol | volume = 2010 | issue =  | pages = 126295 | month =  | year = 2010 | doi = 10.1155/2010/126295 | PMID = 20445756 }}</ref>
*[http://www.ovariancancerprevention.org/wp-content/uploads/2010/10/apotosis-and-mitosis-in-STIC.jpg  STIC - high mag. (ovariancancerprevention.org)].<ref>URL: [http://www.ovariancancerprevention.org/?page_id=191 http://www.ovariancancerprevention.org/?page_id=191]. Accessed on: 13 May 2014.</ref>
*[http://www.ovariancancerprevention.org/wp-content/uploads/2010/10/STIC-junction-HM.jpg STIC & benign - high mag. (ovariancancerprevention.org)].
==IHC==
Features:<ref name=pmid21989347/>
*p53 +ve.
*Ki-67 increased ~10%. (???)
*p16 +ve.<ref name=pmid20228782/>


==See also==
==See also==

Latest revision as of 05:17, 4 November 2024

Serous tubal intraepithelial carcinoma
Diagnosis in short

Micrograph showing serous tubal intraepithelial carcinoma. H&E stain.
LM three of the following five: (1) atypical chromatin pattern, (2) nuclear enlargement, (3) nuclear pleomorphism, (4) nuclear moulding, (5) loss of nuclear polarity or epithelial stratification
IHC p16 +ve, p53 +ve, Ki-67 increased
Molecular BRCA1 mutation or BRCA2 mutation
Gross not apparent on gross
Site fallopian tubes
Symptoms none
Prevalence uncommon

Serous tubal intraepithelial carcinoma, abbreviated STIC[1] (pronounced stick), is considered to be the precursor of serous carcinoma.

It is also known as tubal intraepithelial carcinoma.

General

  • Considered the precursor lesion for tubal serous carcinoma.[2]
  • Seen in ~6% of prophylactic salpingo-oophorectomies in BRCA-mutation carriers.[3]

Gross

  • Not apparent on gross.
  • Usually at the fimbriated end of the tube.

Microscopic

Features:[4]

  • Discrete papillary growth - low power.
  • Formal criteria - need 3 or more:
    1. Atypical chromatin pattern.
    2. Nuclear enlargement.
    3. Nuclear pleomorphism.
    4. Nuclear moulding.
    5. Loss of nuclear polarity or epithelial stratification.

Notes:

  • At low power STIC is usually tall cells that are too blue.
  • Cilia suggest benign.

DDx:

Images

  • STIC - extremely low mag. (WC)

  • STIC - very low mag. (WC)

  • STIC - low mag. (WC)

  • STIC - intermed. mag. (WC)

  • STIC - intermed. mag. (WC)

  • STIC - high mag. (WC)

  • STIC - high mag. (WC)

  • STIC - very high mag. (WC)

www

IHC

Features:[1]

  • p53 +ve.
  • Ki-67 increased ~10%. (???)
  • p16 +ve.[4]

Images

  • STIC - p16 - very low mag. (WC)

  • STIC - p16 - low mag. (WC)

  • STIC - p16 - intermed. mag. (WC)

  • STIC - p16 - high mag. (WC)

  • STIC - p53 - very low mag. (WC)

  • STIC - p53 - low mag. (WC)

  • STIC - p53 - intermed. mag. (WC)

  • STIC - p53 - high mag. (WC)

  • STIC - Ki-67 - very low mag. (WC)

  • STIC - Ki-67 - low mag. (WC)

  • STIC - Ki-67 - high mag. (WC)

See also

References

  1. ↑ 1.0 1.1 Visvanathan, K.; Vang, R.; Shaw, P.; Gross, A.; Soslow, R.; Parkash, V.; Shih, IeM.; Kurman, RJ. (Dec 2011). "Diagnosis of serous tubal intraepithelial carcinoma based on morphologic and immunohistochemical features: a reproducibility study.". Am J Surg Pathol 35 (12): 1766-75. doi:10.1097/PAS.0b013e31822f58bc. PMID 21989347.
  2. ↑ Lee, Y.; Miron, A.; Drapkin, R.; Nucci, MR.; Medeiros, F.; Saleemuddin, A.; Garber, J.; Birch, C. et al. (Jan 2007). "A candidate precursor to serous carcinoma that originates in the distal fallopian tube.". J Pathol 211 (1): 26-35. doi:10.1002/path.2091. PMID 17117391.
  3. ↑ Mingels MJ, Roelofsen T, van der Laak JA, et al. (October 2012). "Tubal epithelial lesions in salpingo-oophorectomy specimens of BRCA-mutation carriers and controls". Gynecol. Oncol. 127 (1): 88–93. doi:10.1016/j.ygyno.2012.06.015. PMID 22710074.
  4. ↑ 4.0 4.1 4.2 Sehdev, AS.; Kurman, RJ.; Kuhn, E.; Shih, IeM. (Jun 2010). "Serous tubal intraepithelial carcinoma upregulates markers associated with high-grade serous carcinomas including Rsf-1 (HBXAP), cyclin E and fatty acid synthase.". Mod Pathol 23 (6): 844-55. doi:10.1038/modpathol.2010.60. PMID 20228782.
  5. ↑ Nishida N, Murakami F, Higaki K (June 2016). "Detection of serous precursor lesions in resected fallopian tubes from patients with benign diseases and a relatively low risk for ovarian cancer". Pathol Int 66 (6): 337–42. doi:10.1111/pin.12419. PMID 27250113.
  6. ↑ 6.0 6.1 6.2 Kurman, RJ.; Shih, IeM. (Jul 2011). "Molecular pathogenesis and extraovarian origin of epithelial ovarian cancer--shifting the paradigm.". Hum Pathol 42 (7): 918-31. doi:10.1016/j.humpath.2011.03.003. PMID 21683865.
  7. ↑ Gross, AL.; Kurman, RJ.; Vang, R.; Shih, IeM.; Visvanathan, K. (2010). "Precursor lesions of high-grade serous ovarian carcinoma: morphological and molecular characteristics.". J Oncol 2010: 126295. doi:10.1155/2010/126295. PMID 20445756.
  8. ↑ URL: http://www.ovariancancerprevention.org/?page_id=191. Accessed on: 13 May 2014.

External links

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