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Difference between revisions of "Renal cell carcinoma with fibromyomatous stroma"
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Renal cell carcinoma with fibromyomatous stroma (view source)
Revision as of 20:32, 21 October 2024
, 20:32, 21 October 2024no edit summary
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''Renal cell carcinoma with leiomyomatous stroma'' redirects here. | ''Renal cell carcinoma with leiomyomatous stroma'' redirects here. | ||
==General== | |||
*Rare tumour: 12 in >500 renal cell carcinomas with clear cells.<ref name=pmid36592877/> | |||
==Microscopic== | ==Microscopic== | ||
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!CD10 | !CD10 | ||
!CK34betaE12 (K903) | !CK34betaE12 (K903) | ||
!GPNMB | ![[GPNMB]] | ||
|- | |- | ||
|Clear cell renal cell carcinoma | |Clear cell renal cell carcinoma | ||
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| -ve | | -ve | ||
|- | |- | ||
| | |Renal cell carcinoma with fibromyomatous stroma | ||
| +ve | | +ve | ||
| +ve | | +ve | ||
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==Molecular== | ==Molecular== | ||
*[[Renal neoplasms with TSC/mTOR pathway mutations|TSC/mTOR pathway mutation]].<ref name=pmid36592877/> | *[[Renal neoplasms with TSC/mTOR pathway mutations|TSC/mTOR pathway mutation]].<ref name=pmid36592877/> | ||
**A somewhat non-specific finding as [[Renal neoplasms with TSC/mTOR pathway mutations|several renal tumours (with a different morphology) have TSC/mTOR pathway mutations]]. | |||
==Sign out== | |||
===Molecular lacking=== | |||
<pre> | |||
Right Kidney, Radical Nephrectomy: | |||
- RENAL CELL CARCINOMA with clear cells, cysts and leiomyomatous stroma, see comment. | |||
-- Margin clear. | |||
-- Please see synoptic report for details. | |||
Comment: | |||
The tumour stains as follows: | |||
POSITIVE: CD10 (moderate), EMA (patchy), CK7 (diffuse), PAX8 (diffuse). | |||
NEGATIVE: CK34betaE12, CK20. | |||
The differential diagnosis includes: (1) clear cell renal cell carcinoma, (2) RCC with a mTOR pathway mutation, and (3) ELOC-mutated RCC. | |||
</pre> | |||
==See also== | ==See also== | ||