Olfactory neuroblastoma: Difference between revisions

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+/-Flexner-Wintersteiner [[rosette]] (rosette with empty centre), +/-Fibrillary, eosinophilic material (neuropil-like)
+/-Flexner-Wintersteiner [[rosette]] (rosette with empty centre), +/-Fibrillary, eosinophilic material (neuropil-like)
| Subtypes  =
| Subtypes  =
| LMDDx      = other small round blue cell tumours, e.g. [[small cell carcinoma of the lung]], large cell lymphoma (e.g. [[DLBCL]]), basaloid squamous cell carcinoma
| LMDDx      = other small round blue cell tumours (e.g. [[small cell carcinoma of the lung]]), large cell lymphoma (e.g. [[DLBCL]]), basaloid squamous cell carcinoma
| Stains    =
| Stains    =
| IHC        =
| IHC        =
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==IHC==
==IHC==
*[[Neuroendocrine markers]]:<ref name=pmid36452592>{{cite journal |vauthors=Rao KR, Upadhya IB |title=A Review on Esthesioneuroblastoma |journal=Indian J Otolaryngol Head Neck Surg |volume=74 |issue=Suppl 2 |pages=1584–1590 |date=October 2022 |pmid=36452592 |pmc=9702120 |doi=10.1007/s12070-021-02726-2 |url=}}</ref>
**CD56 +ve.
**Synaptophysin +ve.
**Chromogranin A +ve.
**NSE +ve.
***Lower expression of neuroendocrine markers in IDH2 mutant tumors.{{fact}}
*S-100:
*S-100:
**Small round cells -ve.
**Small round cells -ve.
**Sustentacular cells +ve.
**Sustentacular cells +ve.
***Neuronal ONB subtype is enriched for the presence of S100 sustentacular cells.
***Neuronal ONB subtype is enriched for the presence of S100 sustentacular cells.
*[[Neuroendocrine markers]] +ve (CD56, synaptophysin).
**lower expression of neuroendocrine markers in IDH2 mutant tumors.


Others:
Others:
*CD45 -ve (r/o [[lymphoma]]).
*CD45 -ve (r/o [[lymphoma]]).
*AE1/AE3 usu. -ve (r/o carcinoma).
*AE1/AE3 usually -ve (~1/3 are +ve<ref name=pmid36452592/>).
*CAM5.2 usu. -ve -- up to 35% +ve.<ref name=Ref_WMSP41>{{Ref WMSP|41}}</ref>
*CAM5.2 usu. -ve -- up to 35% +ve.<ref name=Ref_WMSP41>{{Ref WMSP|41}}</ref>
**Higher expression of cytokeratins in IDH2 mutant tumors.
**Higher expression of cytokeratins in IDH2 mutant tumors.
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[[Category:Head and neck pathology]]
[[Category:Head and neck pathology]]
[[Categorgy:Neuropathology]]
[[Category:Neuropathology]]
[[Category:Diagnosis]]
[[Category:Diagnosis]]
Retrieved from "https://librepathology.org/wiki/Olfactory_neuroblastoma"