Gallbladder adenoma: Difference between revisions
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{{ Infobox diagnosis | |||
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| Synonyms = | |||
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| Subtypes = | |||
| LMDDx = [[adenocarcinoma of the gallbladder]], reactive changes - as may be seen in [[acute cholecystitis]] | |||
| Stains = | |||
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| Gross = | |||
| Grossing = [[gallbladder grossing]] | |||
| Staging = | |||
| Site = [[gallbladder]] | |||
| Assdx = | |||
| Syndromes = [[familial adenomatous polyposis]], [[Peutz-Jeghers syndrome]] | |||
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| Symptoms = | |||
| Prevalence = uncommon | |||
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}} | |||
'''Gallbladder adenoma''' is a pre-malignant lesion of the [[gallbladder]]. | '''Gallbladder adenoma''' is a pre-malignant lesion of the [[gallbladder]]. | ||
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Notes: | Notes: | ||
*Low grade dysplasia should prompt targeted sampling and review.<ref name=uscap2017_akki/> | *Low grade dysplasia should prompt targeted sampling and review.<ref name=uscap2017_akki/> | ||
*Gallbladders with high grade dysplasia should be [[submitted in total]] to exclude [[gallbladder adenocarcinoma]].<ref name=uscap2017_akki>Akki ''et al.'' (2017) "Detecting Incidental Gallbladder Adenocarcinoma: When to Submit the Entire Gallbladder". Available at: [http://www.abstracts2view.com/uscap17/view.php?nu=USCAP17L_2016 http://www.abstracts2view.com/uscap17/view.php?nu=USCAP17L_2016]. United States and Canadian Academy of Pathology Annual Meeting. Accessed on: April 9, 2017.</ref> | *Gallbladders with high grade dysplasia should be [[submitted in total]] to exclude [[gallbladder adenocarcinoma]].<ref name=uscap2017_akki>Akki ''et al.'' (2017) "Detecting Incidental Gallbladder Adenocarcinoma: When to Submit the Entire Gallbladder". Available at: [http://www.abstracts2view.com/uscap17/view.php?nu=USCAP17L_2016 http://www.abstracts2view.com/uscap17/view.php?nu=USCAP17L_2016]. United States and Canadian Academy of Pathology Annual Meeting. Accessed on: April 9, 2017.</ref><ref name=pmid33629395/> | ||
DDx: | DDx: | ||
*[[Gallbladder adenocarcinoma]]. | *[[Gallbladder adenocarcinoma]]. | ||
*Reactive changes. | *Reactive changes. | ||
===Grading dysplasia=== | |||
Low grade dysplasia:<ref name=pmid33629395>{{cite journal |authors=Roa JC, Basturk O, Adsay V |title=Dysplasia and carcinoma of the gallbladder: pathological evaluation, sampling, differential diagnosis and clinical implications |journal=Histopathology |volume=79 |issue=1 |pages=2–19 |date=July 2021 |pmid=33629395 |doi=10.1111/his.14360 |url=}}</ref> | |||
*Surface epithelium changes: hyperchromasia, pseudostratification, elongated nuclei; nuclei stratified/confined mainly to lower aspect of the epithelium. | |||
High grade dysplasia:<ref name=pmid33629395/> | |||
*Diffuse and severe (cytologic) atypia: nuclei no long stratified. | |||
===Images=== | ===Images=== | ||