Renal oncocytoma: Difference between revisions

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*[[CD117]] +ve.<ref>{{Cite journal | last1 = Krüger | first1 = S. | last2 = Sotlar | first2 = K. | last3 = Kausch | first3 = I. | last4 = Horny | first4 = HP. | title = Expression of KIT (CD117) in renal cell carcinoma and renal oncocytoma. | journal = Oncology | volume = 68 | issue = 2-3 | pages = 269-75 | month = | year = 2005 | doi = 10.1159/000086783 | PMID = 16015044 }}</ref>

**ChRCC also +ve.

*GATA-3 -ve.

*GATA-3 usually -ve (38 cases negative of 47 cases).<ref name=pmid2431520>{{cite journal |authors=Gonzalez-Roibon N, Faraj SF, Munari E, Bezerra SM, Albadine R, Sharma R, Argani P, Allaf ME, Netto GJ |title=Comprehensive profile of GATA binding protein 3 immunohistochemical expression in primary and metastatic renal neoplasms |journal=Hum Pathol |volume=45 |issue=2 |pages=244–8 |date=February 2014 |pmid=24315206 |doi=10.1016/j.humpath.2013.08.020 |url=}}</ref>

**+ve in [[low-grade oncocytic renal tumour]].

Line 113:

*PAX2 +ve.<ref name=pmid17210525>{{cite journal |author=Memeo L, Jhang J, Assaad AM, ''et al.'' |title=Immunohistochemical analysis for cytokeratin 7, KIT, and PAX2: value in the differential diagnosis of chromophobe cell carcinoma |journal=Am. J. Clin. Pathol. |volume=127 |issue=2 |pages=225–9 |year=2007 |month=February |pmid=17210525 |doi=10.1309/9KWEA4W9Y94D1AEE |url=http://ajcp.ascpjournals.org/cgi/pmidlookup?view=long&pmid=17210525}}</ref>

**Oncocytoma 20 of 23 +ve versus ChRCC 1 of 11 +ve.

*AMACR -ve.<ref name=pmid26925847>{{Cite journal | last1 = Lüders | first1 = C. | last2 = Kristiansen | first2 = G. | title = [Oncocytoma versus chromophobe renal cell carcinoma : Is there something in between?]. | journal = Pathologe | volume = 37 | issue = 2 | pages = 153-8 | month = Mar | year = 2016 | doi = 10.1007/s00292-016-0145-0 | PMID = 26925847 }}</ref>

*AMACR -ve<ref name=pmid26925847>{{Cite journal | last1 = Lüders | first1 = C. | last2 = Kristiansen | first2 = G. | title = [Oncocytoma versus chromophobe renal cell carcinoma : Is there something in between?]. | journal = Pathologe | volume = 37 | issue = 2 | pages = 153-8 | month = Mar | year = 2016 | doi = 10.1007/s00292-016-0145-0 | PMID = 26925847 }}</ref> or variable.<ref>{{Cite journal | last1 = Wobker | first1 = S.E.| last2 = Williamson | first2 = S.R. | title = Modern Pathologic Diagnosis of Renal Oncocytoma | journal = J Kidney Cancer VHL | volume = 4 | issue = 4 | pages = 1-12 | month = Oct | year = 2017 | doi = 10.15586/jkcvhl.2017.96 | PMID = 29090117}}</ref>

*Vimentin -ve.<ref name=pmid26925847/>

A panel:

*CK7, PAX8, CD117, CD10, [[Mueller-Mowry stain]], GATA-3.

===Comparison between some renal tumours with eosinophilic cytoplasm===

{| class="wikitable sortable"

!Tumour

![[CK7]]

![[CD117]]

![[GATA3]]

|-

| Renal oncocytoma

| -ve †

| +ve

| -ve/+ve

|-

| [[Chromophobe renal cell carcinoma]]

| +ve ‡

| +ve

| -ve

|-

| [[Low-grade oncocytic tumour]]

| +ve

| -ve

| +ve

|-

|}

† may have scattered positive cells<br>

‡ diffuse and strong

==Sign out==

@@ Line 105: / Line 105: @@
 *[[CD117]] +ve.<ref>{{Cite journal  | last1 = Krüger | first1 = S. | last2 = Sotlar | first2 = K. | last3 = Kausch | first3 = I. | last4 = Horny | first4 = HP. | title = Expression of KIT (CD117) in renal cell carcinoma and renal oncocytoma. | journal = Oncology | volume = 68 | issue = 2-3 | pages = 269-75 | month =  | year = 2005 | doi = 10.1159/000086783 | PMID = 16015044 }}</ref>
 **ChRCC also +ve.
-*GATA-3 -ve.
+*GATA-3 usually -ve (38 cases negative of 47 cases).<ref name=pmid2431520>{{cite journal |authors=Gonzalez-Roibon N, Faraj SF, Munari E, Bezerra SM, Albadine R, Sharma R, Argani P, Allaf ME, Netto GJ |title=Comprehensive profile of GATA binding protein 3 immunohistochemical expression in primary and metastatic renal neoplasms |journal=Hum Pathol |volume=45 |issue=2 |pages=244–8 |date=February 2014 |pmid=24315206 |doi=10.1016/j.humpath.2013.08.020 |url=}}</ref>
 **+ve in [[low-grade oncocytic renal tumour]].
@@ Line 113: / Line 113: @@
 *PAX2 +ve.<ref name=pmid17210525>{{cite journal |author=Memeo L, Jhang J, Assaad AM, ''et al.'' |title=Immunohistochemical analysis for cytokeratin 7, KIT, and PAX2: value in the differential diagnosis of chromophobe cell carcinoma |journal=Am. J. Clin. Pathol. |volume=127 |issue=2 |pages=225–9 |year=2007 |month=February |pmid=17210525 |doi=10.1309/9KWEA4W9Y94D1AEE |url=http://ajcp.ascpjournals.org/cgi/pmidlookup?view=long&pmid=17210525}}</ref>
 **Oncocytoma 20 of 23 +ve versus ChRCC 1 of 11 +ve.
-*AMACR -ve.<ref name=pmid26925847>{{Cite journal  | last1 = Lüders | first1 = C. | last2 = Kristiansen | first2 = G. | title = [Oncocytoma versus chromophobe renal cell carcinoma : Is there something in between?]. | journal = Pathologe | volume = 37 | issue = 2 | pages = 153-8 | month = Mar | year = 2016 | doi = 10.1007/s00292-016-0145-0 | PMID = 26925847 }}</ref>
+*AMACR -ve<ref name=pmid26925847>{{Cite journal  | last1 = Lüders | first1 = C. | last2 = Kristiansen | first2 = G. | title = [Oncocytoma versus chromophobe renal cell carcinoma : Is there something in between?]. | journal = Pathologe | volume = 37 | issue = 2 | pages = 153-8 | month = Mar | year = 2016 | doi = 10.1007/s00292-016-0145-0 | PMID = 26925847 }}</ref> or variable.<ref>{{Cite journal  | last1 =  Wobker | first1 = S.E.| last2 = Williamson | first2 = S.R. | title = Modern Pathologic Diagnosis of Renal Oncocytoma | journal = J Kidney Cancer VHL | volume = 4 | issue = 4 | pages = 1-12 | month = Oct | year = 2017 | doi = 10.15586/jkcvhl.2017.96 | PMID = 29090117}}</ref>
 *Vimentin -ve.<ref name=pmid26925847/>
 A panel:
 *CK7, PAX8, CD117, CD10, [[Mueller-Mowry stain]], GATA-3.
+===Comparison between some renal tumours with eosinophilic cytoplasm===
+{| class="wikitable sortable"
+!Tumour
+![[CK7]]
+![[CD117]]
+![[GATA3]]
+|-
+| Renal oncocytoma
+| -ve †
+| +ve
+| -ve/+ve
+|-
+| [[Chromophobe renal cell carcinoma]]
+| +ve ‡
+| +ve
+| -ve
+|-
+| [[Low-grade oncocytic tumour]]
+| +ve
+| -ve
+| +ve
+|-
+|}
+† may have scattered positive cells<br>
+‡ diffuse and strong
 ==Sign out==

Renal oncocytoma: Difference between revisions

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