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Difference between revisions of "GATA3"
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| Abbrev = | | Abbrev = | ||
| Synonyms = | | Synonyms = | ||
| Similar = [[thrombomodulin]], | | Similar = [[thrombomodulin]], mammaglobin | ||
| Clones = | | Clones = | ||
| Use = bladder versus prostate, bladder versus SCC, breast versus other, parathyroid versus thyroid | | Use = bladder versus prostate, bladder versus SCC, breast versus other, parathyroid versus thyroid | ||
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**[[Lobular breast carcinoma]].<ref name=pmid24061521>{{Cite journal | last1 = Ellis | first1 = CL. | last2 = Chang | first2 = AG. | last3 = Cimino-Mathews | first3 = A. | last4 = Argani | first4 = P. | last5 = Youssef | first5 = RF. | last6 = Kapur | first6 = P. | last7 = Montgomery | first7 = EA. | last8 = Epstein | first8 = JI. | title = GATA-3 immunohistochemistry in the differential diagnosis of adenocarcinoma of the urinary bladder. | journal = Am J Surg Pathol | volume = 37 | issue = 11 | pages = 1756-60 | month = Nov | year = 2013 | doi = 10.1097/PAS.0b013e31829cdba7 | PMID = 24061521 }}</ref> | **[[Lobular breast carcinoma]].<ref name=pmid24061521>{{Cite journal | last1 = Ellis | first1 = CL. | last2 = Chang | first2 = AG. | last3 = Cimino-Mathews | first3 = A. | last4 = Argani | first4 = P. | last5 = Youssef | first5 = RF. | last6 = Kapur | first6 = P. | last7 = Montgomery | first7 = EA. | last8 = Epstein | first8 = JI. | title = GATA-3 immunohistochemistry in the differential diagnosis of adenocarcinoma of the urinary bladder. | journal = Am J Surg Pathol | volume = 37 | issue = 11 | pages = 1756-60 | month = Nov | year = 2013 | doi = 10.1097/PAS.0b013e31829cdba7 | PMID = 24061521 }}</ref> | ||
*[[Chromophobe renal cell carcinoma]] ~50% of cases.<ref name=pmid24145643/> | *[[Chromophobe renal cell carcinoma]] ~50% of cases.<ref name=pmid24145643/> | ||
*[[Trophoblastic tumours]] +ve | *[[Trophoblastic tumours]] +ve<ref>{{Cite journal | last1 = Mirkovic | first1 = J. | last2 = Elias | first2 = K. | last3 = Drapkin | first3 = R. | last4 = Barletta | first4 = JA. | last5 = Quade | first5 = B. | last6 = Hirsch | first6 = MS. | title = GATA3 expression in gestational trophoblastic tissues and tumours. | journal = Histopathology | volume = 67 | issue = 5 | pages = 636-44 | month = Nov | year = 2015 | doi = 10.1111/his.12681 | PMID = 25753145 }}</ref> including [[choriocarcinoma]].<ref name=pmid26772394 >{{cite journal |authors=Osman H, Cheng L, Ulbright TM, Idrees MT |title=The utility of CDX2, GATA3, and DOG1 in the diagnosis of testicular neoplasms: an immunohistochemical study of 109 cases |journal=Hum Pathol |volume=48 |issue= |pages=18–24 |date=February 2016 |pmid=26772394 |doi=10.1016/j.humpath.2015.09.028 |url=}}</ref> | ||
*Parathyroid - [[parathyroid hyperplasia]], [[parathyroid adenoma]], [[parathyroid carcinoma]].<ref name=pmid25046229>{{Cite journal | last1 = Ordóñez | first1 = NG. | title = Value of GATA3 immunostaining in the diagnosis of parathyroid tumors. | journal = Appl Immunohistochem Mol Morphol | volume = 22 | issue = 10 | pages = 756-61 | month = | year = | doi = 10.1097/PAI.0000000000000007 | PMID = 25046229 }}</ref> | *Parathyroid - [[parathyroid hyperplasia]], [[parathyroid adenoma]], [[parathyroid carcinoma]].<ref name=pmid25046229>{{Cite journal | last1 = Ordóñez | first1 = NG. | title = Value of GATA3 immunostaining in the diagnosis of parathyroid tumors. | journal = Appl Immunohistochem Mol Morphol | volume = 22 | issue = 10 | pages = 756-61 | month = | year = | doi = 10.1097/PAI.0000000000000007 | PMID = 25046229 }}</ref> | ||
*Salivary gland tumours <ref name=pmid23604756>{{Cite journal | last1 = Schwartz | first1 = LE. | last2 = Begum | first2 = S. | last3 = Westra | first3 = WH. | last4 = Bishop | first4 = JA. | title = GATA3 immunohistochemical expression in salivary gland neoplasms. | journal = Head Neck Pathol | volume = 7 | issue = 4 | pages = 311-5 | month = Dec | year = 2013 | doi = 10.1007/s12105-013-0442-3 | PMID = 23604756 }}</ref> | *Salivary gland tumours <ref name=pmid23604756>{{Cite journal | last1 = Schwartz | first1 = LE. | last2 = Begum | first2 = S. | last3 = Westra | first3 = WH. | last4 = Bishop | first4 = JA. | title = GATA3 immunohistochemical expression in salivary gland neoplasms. | journal = Head Neck Pathol | volume = 7 | issue = 4 | pages = 311-5 | month = Dec | year = 2013 | doi = 10.1007/s12105-013-0442-3 | PMID = 23604756 }}</ref> | ||
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*[[Prostate carcinoma]]. | *[[Prostate carcinoma]]. | ||
**Positive in benign prostate glands with radiation atypia.<ref name=pmid28316088>{{cite journal |authors=Tian W, Dorn D, Wei S, Sanders RD, Matoso A, Shah RB, Gordetsky J |title=GATA3 expression in benign prostate glands with radiation atypia: a diagnostic pitfall |journal=Histopathology |volume=71 |issue=1 |pages=150–155 |date=July 2017 |pmid=28316088 |doi=10.1111/his.13214 |url=}}</ref> | **Positive in benign prostate glands with radiation atypia.<ref name=pmid28316088>{{cite journal |authors=Tian W, Dorn D, Wei S, Sanders RD, Matoso A, Shah RB, Gordetsky J |title=GATA3 expression in benign prostate glands with radiation atypia: a diagnostic pitfall |journal=Histopathology |volume=71 |issue=1 |pages=150–155 |date=July 2017 |pmid=28316088 |doi=10.1111/his.13214 |url=}}</ref> | ||
**Positive staining may be seen in prostatic adenocarcinoma.<ref name=pmid32769430>{{cite journal |vauthors=McDonald TM, Epstein JI |title=Aberrant GATA3 Staining in Prostatic Adenocarcinoma: A Potential Diagnostic Pitfall |journal=Am J Surg Pathol |volume=45 |issue=3 |pages=341–346 |date=March 2021 |pmid=32769430 |doi=10.1097/PAS.0000000000001557 |url=}}</ref> | |||
*[[Squamous cell carcinoma of the lung]].<ref name=pmid22982890/> | *[[Squamous cell carcinoma of the lung]].<ref name=pmid22982890/> | ||