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Difference between revisions of "Cystitis glandularis"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Cystitis cystica et glandularis - alt -- intermed mag.jpg | |||
| Width = | |||
| Caption = Cystitis glandularis. [[H&E stain]]. | |||
| Synonyms = | |||
| Micro = nests of urothelium within the lamina propria with cyst formation; lining cells are glandular (cuboidal and/or columnar epithelium); +/-goblet cells; nests should '''not''' extend into the muscularis propria | |||
| Subtypes = | |||
| LMDDx = [[cystitis cystica]], [[nested variant of urothelial carcinoma]], [[tubular adenoma of the urinary bladder]], [[adenocarcinoma in situ of the urinary bladder]] | |||
| Stains = | |||
| IHC = | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Staging = | |||
| Site = [[urinary bladder]] - see ''[[urothelium]]'' | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = uncommon | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = benign | |||
| Other = | |||
| ClinDDx = | |||
| Tx = | |||
}} | |||
{{ Infobox external links | |||
| Name = Cystitis glandularis | |||
| EHVSC = 10173 | |||
| pathprotocols = | |||
| wikipedia = | |||
| pathoutlines = | |||
}} | |||
'''Cystitis glandularis''' is an uncommon type of inflammatory process that afflicts the [[urinary bladder]] ([[Cystitis|cystitis]]). | |||
''Cystitis cystica et glandularis'' and ''pyelitis cystica et glandularis'' redirect to here. | |||
==General== | |||
*Benign.<ref name=pmid25202387>{{Cite journal | last1 = Yi | first1 = X. | last2 = Lu | first2 = H. | last3 = Wu | first3 = Y. | last4 = Shen | first4 = Y. | last5 = Meng | first5 = Q. | last6 = Cheng | first6 = J. | last7 = Tang | first7 = Y. | last8 = Wu | first8 = F. | last9 = Ou | first9 = R. | title = Cystitis glandularis: A controversial premalignant lesion. | journal = Oncol Lett | volume = 8 | issue = 4 | pages = 1662-1664 | month = Oct | year = 2014 | doi = 10.3892/ol.2014.2360 | PMID = 25202387 }}</ref> | |||
**No increased risk of malignancy on follow-up in an older paper with a cohort of 136 patients.<ref name=pmid18455631>{{cite journal |authors=Smith AK, Hansel DE, Jones JS |title=Role of cystitis cystica et glandularis and intestinal metaplasia in development of bladder carcinoma |journal=Urology |volume=71 |issue=5 |pages=915–8 |date=May 2008 |pmid=18455631 |doi=10.1016/j.urology.2007.11.079 |url=}}</ref> | |||
**An older series of 53 patients with intestinal metaplasia suggests it is not a significant risk for cancer.<ref>{{cite journal |authors=Corica FA, Husmann DA, Churchill BM, Young RH, Pacelli A, Lopez-Beltran A, Bostwick DG |title=Intestinal metaplasia is not a strong risk factor for bladder cancer: study of 53 cases with long-term follow-up |journal=Urology |volume=50 |issue=3 |pages=427–31 |date=September 1997 |pmid=9301710 |doi=10.1016/S0090-4295(97)00294-X |url=}}</ref> | |||
*Can be thought of as [[cystitis cystica]] with mucin-secreting cells lining the cystic spaces.<ref name=Ref_WMSP304>{{Ref WMSP|304}}</ref> | |||
*When seen in conjunction with ''cystitis cystica'' it is called ''cystitis cystica et glandularis''. | |||
Note: | |||
*There are case reports of ''urethritis glandularis'' - the same lesion in the [[urethra]].<ref name=pmid11104631>{{Cite journal | last1 = Chan | first1 = YM. | last2 = Ka-Leung Cheng | first2 = D. | last3 = Nga-Yin Cheung | first3 = A. | last4 = Yuen-Sheung Ngan | first4 = H. | last5 = Wong | first5 = LC. | title = Female urethral adenocarcinoma arising from urethritis glandularis. | journal = Gynecol Oncol | volume = 79 | issue = 3 | pages = 511-4 | month = Dec | year = 2000 | doi = 10.1006/gyno.2000.5968 | PMID = 11104631 }}</ref><ref name=pmid17825180>{{Cite journal | last1 = Yin | first1 = G. | last2 = Liu | first2 = YQ. | last3 = Gao | first3 = P. | last4 = Wang | first4 = XH. | title = Male urethritis glandularis: case report. | journal = Chin Med J (Engl) | volume = 120 | issue = 16 | pages = 1460-1 | month = Aug | year = 2007 | doi = | PMID = 17825180 }}</ref> | |||
==Microscopic== | |||
Features:<ref name=Ref_PBoD1028>{{Ref PBoD|1028}}</ref> | |||
*Nests of urothelium within the lamina propria with cyst formation, i.e. lumens are present. | |||
*Cyst lining cells are cuboidal and/or columnar epithelium. | |||
**Produce mucin. | |||
*+/-Goblet cells, i.e. intestinal metaplasia.<ref name=Ref_WMSP304>{{Ref WMSP|304}}</ref> | |||
Note: | |||
*Nests should '''not''' extend into the muscularis propria. | |||
DDx: | |||
*[[Cystitis cystica]]. | |||
*[[Nested variant of urothelial carcinoma]]. | |||
*[[Tubular adenoma of the urinary bladder]]. | |||
*[[Adenocarcinoma in situ of the urinary bladder]]. | |||
===Images=== | |||
<gallery> | |||
Image: Cystitis cystica et glandularis -- very low mag.jpg | CCG - very low mag. | |||
Image: Cystitis cystica et glandularis -- low mag.jpg | CCG - low mag. | |||
Image: Cystitis cystica et glandularis - alt -- intermed mag.jpg | CCG - intermed mag. | |||
Image: Cystitis cystica et glandularis -- high mag.jpg | CCG - high mag. | |||
</gallery> | |||
www: | |||
*[http://www.webpathology.com/image.asp?n=2&Case=50 Cystitis glandularis (webpathology.com)]. | |||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2684385/figure/F0002/ Cystitis cystica et glandularis (nih.gov)]. | |||
==Sign out== | |||
<pre> | |||
Urinary Bladder Lesion, Transurethral Resection: | |||
- Cystitis cystica et cystica glandularis. | |||
- NEGATIVE for dysplasia and NEGATIVE for malignancy. | |||
</pre> | |||
===Block letters=== | |||
<pre> | |||
URINARY BLADDER NECK, BIOPSY: | |||
- CYSTITIS CYSTICA ET GLANDULARIS. | |||
- NEGATIVE FOR MALIGNANCY. | |||
</pre> | |||
===Micro=== | |||
The sections show urothelial mucosa with bland nests within the lamina propria with cyst formation. The stroma is edematous and has a mixed inflammatory infiltrate consisting of plasma cells, eosinophils, lymphocytes and neutrophils. | |||
==See also== | |||
*[[Urothelium]]. | |||
*[[Intestinal metaplasia]]. | |||
==References== | |||
{{Reflist|1}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||