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Difference between revisions of "Papillary thyroid carcinoma"
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BRAF
(BRAF) |
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| Micro = nuclear changes: nuclear membrane irregularities (e.g. raisinoid shape), +/-nuclear grooves, +/-[[nuclear pseudoinclusions]], +/-nuclear clearing, nuclear enlargement (usu. mild), nucleoli; architectural changes: overlap of nuclei, papillae (not required), +/-[[psammoma bodies]] | | Micro = nuclear changes: nuclear membrane irregularities (e.g. raisinoid shape), +/-nuclear grooves, +/-[[nuclear pseudoinclusions]], +/-nuclear clearing, nuclear enlargement (usu. mild), nucleoli; architectural changes: overlap of nuclei, papillae (not required), +/-[[psammoma bodies]] | ||
| Subtypes = [[Papillary thyroid carcinoma tall cell variant|tall cell variant]], [[Papillary thyroid carcinoma columnar cell variant|columnar cell variant]], [[Papillary thyroid carcinoma follicular variant|follicular variant]], [[Papillary thyroid carcinoma cribriform-morular variant|cribriform-morular variant]], [[Papillary thyroid carcinoma diffuse sclerosing variant|diffuse sclerosing variant]], [[Papillary thyroid carcinoma Warthin-like variant|Warthin-like variant]], [[Papillary thyroid carcinoma solid variant|solid variant]], [[Papillary thyroid carcinoma oncocytic variant|oncocytic variant]], others | | Subtypes = [[Papillary thyroid carcinoma tall cell variant|tall cell variant]], [[Papillary thyroid carcinoma columnar cell variant|columnar cell variant]], [[Papillary thyroid carcinoma follicular variant|follicular variant]], [[Papillary thyroid carcinoma cribriform-morular variant|cribriform-morular variant]], [[Papillary thyroid carcinoma diffuse sclerosing variant|diffuse sclerosing variant]], [[Papillary thyroid carcinoma Warthin-like variant|Warthin-like variant]], [[Papillary thyroid carcinoma solid variant|solid variant]], [[Papillary thyroid carcinoma oncocytic variant|oncocytic variant]], others | ||
| LMDDx = [[lymphocytic thyroiditis]] ([[Graves disease]], [[Hashimoto thyroiditis]]), [[solid cell nest of thyroid]], [[follicular thyroid carcinoma]], [[follicular thyroid adenoma]], [[adenomatoid nodule]] | | LMDDx = [[lymphocytic thyroiditis]] ([[Graves disease]], [[Hashimoto thyroiditis]]), [[solid cell nest of thyroid]], [[follicular thyroid carcinoma]], [[follicular thyroid adenoma]], [[adenomatoid nodule]], [[noninvasive follicular thyroid neoplasm with papillary-like nuclear features]] (NIFTP) | ||
| Stains = | | Stains = | ||
| IHC = HBME-1 +ve, [[CK19]] +ve, Galectin-3 +ve, thyroglobulin +ve, TTF-1 +ve | | IHC = HBME-1 +ve, [[CK19]] +ve, Galectin-3 +ve, thyroglobulin +ve, TTF-1 +ve | ||
| EM = | | EM = | ||
| Molecular = | | Molecular = BRAF mutation - commonly | ||
| IF = | | IF = | ||
| Gross = | | Gross = | ||
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DDx: | DDx: | ||
*[[Noninvasive follicular thyroid neoplasm with papillary-like nuclear features]] (NIFTP). | |||
*[[Follicular thyroid carcinoma]] - has a fibrous capsule and invasion though it. | *[[Follicular thyroid carcinoma]] - has a fibrous capsule and invasion though it. | ||
*[[Follicular thyroid adenoma]] - surrounded by a fibrous capsule. | *[[Follicular thyroid adenoma]] - surrounded by a fibrous capsule. | ||
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Images: | Images: | ||
===Papillary thyroid carcinoma cribriform-morular variant=== | ===Papillary thyroid carcinoma cribriform-morular variant=== | ||
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===IHC=== | ===IHC=== | ||
Thyroid versus something else: | Thyroid versus something else: | ||
*Thyroglobulin +ve. | *Thyroglobulin +ve.<ref name=pmid23637102>{{Cite journal | last1 = Sathiyamoorthy | first1 = S. | last2 = Maleki | first2 = Z. | title = Cytomorphologic overlap of differentiated thyroid carcinoma and lung adenocarcinoma and diagnostic value of TTF-1 and TGB on cytologic material. | journal = Diagn Cytopathol | volume = 42 | issue = 1 | pages = 5-10 | month = Jan | year = 2014 | doi = 10.1002/dc.22997 | PMID = 23637102 }}</ref> | ||
*TTF-1 ([[thyroid transcription factor-1]]) +ve. | *TTF-1 ([[thyroid transcription factor-1]]) +ve. | ||
*CD15 +ve.{{fact}} | *CD15 +ve.{{fact}} | ||
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===Molecular=== | ===Molecular=== | ||
* | *BRAF mutation.<ref name=pmid35670964>{{cite journal |authors=Lam AK |title=Papillary Thyroid Carcinoma: Current Position in Epidemiology, Genomics, and Classification |journal=Methods Mol Biol |volume=2534 |issue= |pages=1–15 |date=2022 |pmid=35670964 |doi=10.1007/978-1-0716-2505-7_1 |url=}}</ref> | ||
====Tabular summary==== | ====Tabular summary==== | ||