48,706
edits
m (→IHC) |
(tweak) |
||
(12 intermediate revisions by the same user not shown) | |||
Line 8: | Line 8: | ||
| LMDDx = [[embryonal carcinoma]], [[mixed germ cell tumour]] | | LMDDx = [[embryonal carcinoma]], [[mixed germ cell tumour]] | ||
| Stains = | | Stains = | ||
| IHC = AFP +ve, glypican 3 +ve, OCT3 -ve, CK19 +ve | | IHC = [[AFP]] +ve, [[glypican 3]] +ve, OCT3 -ve, [[CK19]] +ve, AE1/AE3 +ve | ||
| EM = | | EM = | ||
| Molecular = | | Molecular = | ||
Line 14: | Line 14: | ||
| Gross = white/yellow mucinous infiltrative mass | | Gross = white/yellow mucinous infiltrative mass | ||
| Grossing = [[orchiectomy grossing]] | | Grossing = [[orchiectomy grossing]] | ||
| Staging = [[testicular cancer staging]] | |||
| Site = [[testis]], other | | Site = [[testis]], other | ||
| Assdx = | | Assdx = | ||
Line 81: | Line 82: | ||
DDx: | DDx: | ||
*[[Embryonal carcinoma]]. | *[[Embryonal carcinoma]] - more [[nuclear atypia]], nuclei usually overlap and classically vesicular. | ||
*[[Mixed germ cell tumour]]. | *[[Mixed germ cell tumour]]. | ||
==== | ===Images=== | ||
====Case 1==== | |||
<gallery> | <gallery> | ||
Image:Mixed_germ_cell_tumour_-_very_high_mag.jpg|Yolk sac tumour. (WC/Nephron) | Image:Mixed_germ_cell_tumour_-_very_high_mag.jpg|Yolk sac tumour. (WC/Nephron) | ||
</gallery> | </gallery> | ||
www | |||
====Case 2==== | |||
<gallery> | |||
Image: Yolk sac tumour with hyaline bodies -- intermed mag.jpg | YST with hyaline bodies - intermed. mag. (WC) | |||
Image: Yolk sac tumour with hyaline bodies -- high mag.jpg | YST with hyaline bodies - high mag. (WC) | |||
Image: Yolk sac tumour with hyaline bodies -- very high mag.jpg | YST with hyaline bodies - very high mag. (WC) | |||
</gallery> | |||
====Case 3==== | |||
<gallery> | |||
Image: Yolk sac tumour -- low mag.jpg | YST - low mag. (WC) | |||
Image: Yolk sac tumour -- intermed mag.jpg | YST - intermed. mag. (WC) | |||
Image: Yolk sac tumour -- high mag.jpg | YST - high mag. (WC) | |||
Image: Yolk sac tumour -- very high mag.jpg | YST - very high mag. (WC) | |||
</gallery> | |||
===www images=== | |||
*[http://webpathology.com/image.asp?case=34&n=6 Hepatoid Pattern (webpathology.com)]. | *[http://webpathology.com/image.asp?case=34&n=6 Hepatoid Pattern (webpathology.com)]. | ||
*[http://www.webpathology.com/image.asp?case=34&n=5 Schiller-Duval body (webpathology.com)]. | *[http://www.webpathology.com/image.asp?case=34&n=5 Schiller-Duval body (webpathology.com)]. | ||
Line 100: | Line 118: | ||
*OCT3 -ve. | *OCT3 -ve. | ||
**Positive in [[seminoma]] and [[embryonal carcinoma]]. | **Positive in [[seminoma]] and [[embryonal carcinoma]]. | ||
*Alpha-fetoprotein (abbreviated AFP) +ve. | *[[Alpha-fetoprotein]] (abbreviated AFP) +ve. | ||
*Glypican 3 +ve. | *[[Glypican 3]] +ve. | ||
**More sensitive than AFP.<ref name=pmid20438407>{{Cite journal | last1 = Emerson | first1 = RE. | last2 = Ulbright | first2 = TM. | title = Intratubular germ cell neoplasia of the testis and its associated cancers: the use of novel biomarkers. | journal = Pathology | volume = 42 | issue = 4 | pages = 344-55 | month = Jun | year = 2010 | doi = 10.3109/00313021003767355 | PMID = 20438407 }}</ref> | **More sensitive than AFP.<ref name=pmid20438407>{{Cite journal | last1 = Emerson | first1 = RE. | last2 = Ulbright | first2 = TM. | title = Intratubular germ cell neoplasia of the testis and its associated cancers: the use of novel biomarkers. | journal = Pathology | volume = 42 | issue = 4 | pages = 344-55 | month = Jun | year = 2010 | doi = 10.3109/00313021003767355 | PMID = 20438407 }}</ref> | ||
*CD117 +ve (~60% +ve in a series of 52 solid YSTs<ref>{{cite journal |authors=Kao CS, Idrees MT, Young RH, Ulbright TM |title=Solid pattern yolk sac tumor: a morphologic and immunohistochemical study of 52 cases |journal=Am J Surg Pathol |volume=36 |issue=3 |pages=360–7 |date=March 2012 |pmid=22261704 |doi=10.1097/PAS.0b013e31823c510b |url=}}</ref>). | |||
Others: | Others: | ||
*CK19 +ve.<ref>{{Cite journal | last1 = Bremmer | first1 = F. | last2 = Ströbel | first2 = P. | last3 = Hubertus | first3 = H. | last4 = Strecker | first4 = J. | last5 = Gaisa | first5 = N. | last6 = Strauß | first6 = A. | last7 = Schweyer | first7 = S. | last8 = Radzun | first8 = H-J. | last9 = Behnes | first9 = C-L | title = CK19 is a sensitive marker for yolk sac tumours of the testis. | journal = Diagnostic Pathology | volume = 10 | issue = 7 | pages = | month = | year = 2015 | doi = 10.1186/s13000-015-0243-y | PMID = | url = www.diagnosticpathology.org/content/10/1/7Cached }}</ref> | *[[CK19]] +ve.<ref>{{Cite journal | last1 = Bremmer | first1 = F. | last2 = Ströbel | first2 = P. | last3 = Hubertus | first3 = H. | last4 = Strecker | first4 = J. | last5 = Gaisa | first5 = N. | last6 = Strauß | first6 = A. | last7 = Schweyer | first7 = S. | last8 = Radzun | first8 = H-J. | last9 = Behnes | first9 = C-L | title = CK19 is a sensitive marker for yolk sac tumours of the testis. | journal = Diagnostic Pathology | volume = 10 | issue = 7 | pages = | month = | year = 2015 | doi = 10.1186/s13000-015-0243-y | PMID = | url = www.diagnosticpathology.org/content/10/1/7Cached }}</ref> | ||
**Seminoma -ve, embryonal carcinoma -ve, ITGCN -ve, normal testis -ve. | **Seminoma -ve, embryonal carcinoma -ve, [[GCNIS]] (ITGCN) -ve, normal testis -ve. | ||
*Cytokeratin +ve.{{fact}} | *Cytokeratin +ve.{{fact}} | ||
*CD30 -ve. | *CD30 -ve. | ||
Line 113: | Line 132: | ||
*Alpha-1-antitrypsin +ve (abbreviated A1A).<ref name=pmid89123>{{Cite journal | last1 = Beilby | first1 = JO. | last2 = Horne | first2 = CH. | last3 = Milne | first3 = GD. | last4 = Parkinson | first4 = C. | title = Alpha-fetoprotein, alpha-1-antitrypsin, and transferrin in gonadal yolk-sac tumours. | journal = J Clin Pathol | volume = 32 | issue = 5 | pages = 455-61 | month = May | year = 1979 | doi = | PMID = 89123 }}</ref> | *Alpha-1-antitrypsin +ve (abbreviated A1A).<ref name=pmid89123>{{Cite journal | last1 = Beilby | first1 = JO. | last2 = Horne | first2 = CH. | last3 = Milne | first3 = GD. | last4 = Parkinson | first4 = C. | title = Alpha-fetoprotein, alpha-1-antitrypsin, and transferrin in gonadal yolk-sac tumours. | journal = J Clin Pathol | volume = 32 | issue = 5 | pages = 455-61 | month = May | year = 1979 | doi = | PMID = 89123 }}</ref> | ||
*[[CDX2]] +ve in 8 of 20 cases with YST (versus glypican-3).<ref name=pmid19578052>{{Cite journal | last1 = Bing | first1 = Z. | last2 = Pasha | first2 = T. | last3 = Tomaszewski | first3 = JE. | last4 = Zhang | first4 = P. | title = CDX2 expression in yolk sac component of testicular germ cell tumors. | journal = Int J Surg Pathol | volume = 17 | issue = 5 | pages = 373-7 | month = Oct | year = 2009 | doi = 10.1177/1066896909338598 | PMID = 19578052 }}</ref> | *[[CDX2]] +ve in 8 of 20 cases with YST (versus glypican-3).<ref name=pmid19578052>{{Cite journal | last1 = Bing | first1 = Z. | last2 = Pasha | first2 = T. | last3 = Tomaszewski | first3 = JE. | last4 = Zhang | first4 = P. | title = CDX2 expression in yolk sac component of testicular germ cell tumors. | journal = Int J Surg Pathol | volume = 17 | issue = 5 | pages = 373-7 | month = Oct | year = 2009 | doi = 10.1177/1066896909338598 | PMID = 19578052 }}</ref> | ||
*SOX2 -ve (0 of 17<ref name=pmid19369635>{{cite journal |authors=Nonaka D |title=Differential expression of SOX2 and SOX17 in testicular germ cell tumors |journal=Am J Clin Pathol |volume=131 |issue=5 |pages=731–6 |date=May 2009 |pmid=19369635 |doi=10.1309/AJCP7MNCNBCRN8NO |url=}}</ref>). | |||
*SOX17 +ve (17 of 17 cases<ref name=pmid19369635/>). | |||
A panel: | |||
*SALL4 +ve, AE1/AE3 +ve, CD30 -ve, glypican-3 +ve. | |||
==See also== | ==See also== |
edits