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Difference between revisions of "Eosinophilic, solid and cystic renal cell carcinoma"
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Eosinophilic, solid and cystic renal cell carcinoma (view source)
Revision as of 03:16, 25 April 2024
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| IHC = [[PAX8]] +ve, [[CK20]] +ve, [[CK7]] -ve, CA9 -ve, CD117 -ve, HMB-45 -ve | | IHC = [[PAX8]] +ve, [[CK20]] +ve, [[CK7]] -ve, CA9 -ve, CD117 -ve, HMB-45 -ve | ||
| EM = | | EM = | ||
| Molecular = | | Molecular = [[Renal neoplasms with TSC/mTOR pathway mutations|TSC/mTOR pathway mutations]] | ||
| IF = | | IF = | ||
| Gross = solid and cystic | | Gross = solid and cystic | ||
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'''Eosinophilic, solid and cystic renal cell carcinoma''', abbreviated '''ESC-RCC''', is recently described, evolving [[kidney tumour]] that is presumed to be [[malignant]].<ref name=pmid26414221>{{Cite journal | last1 = Trpkov | first1 = K. | last2 = Hes | first2 = O. | last3 = Bonert | first3 = M. | last4 = Lopez | first4 = JI. | last5 = Bonsib | first5 = SM. | last6 = Nesi | first6 = G. | last7 = Comperat | first7 = E. | last8 = Sibony | first8 = M. | last9 = Berney | first9 = DM. | title = Eosinophilic, Solid, and Cystic Renal Cell Carcinoma: Clinicopathologic Study of 16 Unique, Sporadic Neoplasms Occurring in Women. | journal = Am J Surg Pathol | volume = | issue = | pages = | month = Sep | year = 2015 | doi = 10.1097/PAS.0000000000000508 | PMID = 26414221 }}</ref> | '''Eosinophilic, solid and cystic renal cell carcinoma''', abbreviated '''ESC-RCC''', is recently described, evolving [[kidney tumour]] that is presumed to be [[malignant]].<ref name=pmid26414221>{{Cite journal | last1 = Trpkov | first1 = K. | last2 = Hes | first2 = O. | last3 = Bonert | first3 = M. | last4 = Lopez | first4 = JI. | last5 = Bonsib | first5 = SM. | last6 = Nesi | first6 = G. | last7 = Comperat | first7 = E. | last8 = Sibony | first8 = M. | last9 = Berney | first9 = DM. | title = Eosinophilic, Solid, and Cystic Renal Cell Carcinoma: Clinicopathologic Study of 16 Unique, Sporadic Neoplasms Occurring in Women. | journal = Am J Surg Pathol | volume = | issue = | pages = | month = Sep | year = 2015 | doi = 10.1097/PAS.0000000000000508 | PMID = 26414221 }}</ref> | ||
It is ''not'' within the | It is ''not'' within the WHO 2016 classification of [[renal tumours|renal neoplasia]]. | ||
==General== | ==General== | ||
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*CA9 -ve. | *CA9 -ve. | ||
*HMB-45 -ve. | *HMB-45 -ve. | ||
==Molecular== | |||
*[[Renal neoplasms with TSC/mTOR pathway mutations|TSC/mTOR pathway mutations]].<ref name=pmid35203531>{{cite journal |authors=Pivovarcikova K, Alaghehbandan R, Vanecek T, Ohashi R, Pitra T, Hes O |title=TSC/mTOR Pathway Mutation Associated Eosinophilic/Oncocytic Renal Neoplasms: A Heterogeneous Group of Tumors with Distinct Morphology, Immunohistochemical Profile, and Similar Genetic Background |journal=Biomedicines |volume=10 |issue=2 |pages= |date=January 2022 |pmid=35203531 |pmc=8869370 |doi=10.3390/biomedicines10020322 |url=}}</ref> | |||
==See also== | ==See also== | ||