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Difference between revisions of "Granular cell tumour"
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==General== | ==General== | ||
*A nerve shealth tumour.<ref name=pmid22668577>{{cite journal |authors=Izquierdo F, Suárez-Vilela D, Honrado E |title=Perineurial cells in granular cell tumors and neoplasms with perineural invasion: an immunohistochemical study |journal=Am J Dermatopathol |volume=34 |issue=8 |pages=800–9 |date=December 2012 |pmid=22668577 |doi=10.1097/DAD.0b013e31824ba93b |url=}}</ref> | |||
*Rare. | *Rare. | ||
*Usually benign. | *Usually benign. | ||
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***Size: 1-3 micrometers. | ***Size: 1-3 micrometers. | ||
***Poorly demarcated (on light microscopy). | ***Poorly demarcated (on light microscopy). | ||
*Nested architecture. | **Poorly defined cellular borders. | ||
*Nested architecture or syncytial growth pattern. | |||
*+/-Pustulo-ovoid bodies (focal eosinophilic granules surrounded by a clear halo).<ref name=pmid22760808>{{Cite journal | last1 = Fernandes | first1 = BF. | last2 = Belfort Neto | first2 = R. | last3 = Odashiro | first3 = AN. | last4 = Pereira | first4 = PR. | last5 = Burnier | first5 = MN. | title = Clinical and histopathological features of orbital granular cell tumor: case report. | journal = Arq Bras Oftalmol | volume = 75 | issue = 2 | pages = 137-9 | month = | year = | doi = | PMID = 22760808 }}</ref> | |||
*+/-Pseudoepitheliomatous hyperplasia. | *+/-Pseudoepitheliomatous hyperplasia. | ||
**May mimic [[SCC]]. | **May mimic [[SCC]]. | ||
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==Special stains== | ==Special stains== | ||
*PAS +ve. | *PAS +ve. | ||
*PASD +ve (pustulo-ovoid bodies). | |||
==IHC== | ==IHC== | ||
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*Vimentin +ve (membranous). | *Vimentin +ve (membranous). | ||
*Calretinin +ve (90-95%).<ref name=pmid12579997>{{Cite journal | last1 = Fine | first1 = SW. | last2 = Li | first2 = M. | title = Expression of calretinin and the alpha-subunit of inhibin in granular cell tumors. | journal = Am J Clin Pathol | volume = 119 | issue = 2 | pages = 259-64 | month = Feb | year = 2003 | doi = 10.1309/GRH4-JWX6-J9J7-QQTA | PMID = 12579997 }}</ref> | *Calretinin +ve (90-95%).<ref name=pmid12579997>{{Cite journal | last1 = Fine | first1 = SW. | last2 = Li | first2 = M. | title = Expression of calretinin and the alpha-subunit of inhibin in granular cell tumors. | journal = Am J Clin Pathol | volume = 119 | issue = 2 | pages = 259-64 | month = Feb | year = 2003 | doi = 10.1309/GRH4-JWX6-J9J7-QQTA | PMID = 12579997 }}</ref> | ||
*SOX10 +ve (11 of 11 cases).<ref name=pmid37026754>{{cite journal |authors=Malik F, Bernieh A, Saad AG |title=Esophageal Granular Cell Tumor in Children: A Clinicopathologic Study of 11 Cases and Review of the Literature |journal=Am J Clin Pathol |volume=160 |issue=1 |pages=106–112 |date=July 2023 |pmid=37026754 |doi=10.1093/ajcp/aqad025 |url=}}</ref> | |||
===Images=== | ===Images=== | ||