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Difference between revisions of "Renal oncocytoma"
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*Cells arranged in nests. | *Cells arranged in nests. | ||
*Nuclei uniform and round.<ref name=Ref_GUP302>{{Ref GUP|302}}</ref> | *Nuclei uniform and round.<ref name=Ref_GUP302>{{Ref GUP|302}}</ref> | ||
**Slightly enlarged nuclei, but '''no significant''' pleomorphism (size variation) - '''important'''. | **Slightly enlarged nuclei, but '''no significant''' pleomorphism (size variation) - '''important'''.‡ | ||
Notes: | Notes: | ||
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**Focal clear cell changes ~15% of cases. | **Focal clear cell changes ~15% of cases. | ||
**Hemorrhage. | **Hemorrhage. | ||
*‡ Focal "degenerative" atypia can be present; it is reported in ~20% of cases.<ref>{{cite journal |authors=Tickoo SK, Amin MB |title=Discriminant nuclear features of renal oncocytoma and chromophobe renal cell carcinoma. Analysis of their potential utility in the differential diagnosis |journal=Am J Clin Pathol |volume=110 |issue=6 |pages=782–7 |date=December 1998 |pmid=9844591 |doi=10.1093/ajcp/110.6.782 |url=}}</ref> | |||
DDx: | DDx: | ||
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==IHC== | ==IHC== | ||
*[[CK7]] -ve<ref name=pmid17683191>{{Cite journal | last1 = Liu | first1 = L. | last2 = Qian | first2 = J. | last3 = Singh | first3 = H. | last4 = Meiers | first4 = I. | last5 = Zhou | first5 = X. | last6 = Bostwick | first6 = DG. | title = Immunohistochemical analysis of chromophobe renal cell carcinoma, renal oncocytoma, and clear cell carcinoma: an optimal and practical panel for differential diagnosis. | journal = Arch Pathol Lab Med | volume = 131 | issue = 8 | pages = 1290-7 | month = Aug | year = 2007 | doi = 10.1043/1543-2165(2007)131[1290:IAOCRC]2.0.CO;2 | PMID = 17683191 }}</ref>/+ve (cytoplasmic) . | *[[CK7]] -ve<ref name=pmid17683191>{{Cite journal | last1 = Liu | first1 = L. | last2 = Qian | first2 = J. | last3 = Singh | first3 = H. | last4 = Meiers | first4 = I. | last5 = Zhou | first5 = X. | last6 = Bostwick | first6 = DG. | title = Immunohistochemical analysis of chromophobe renal cell carcinoma, renal oncocytoma, and clear cell carcinoma: an optimal and practical panel for differential diagnosis. | journal = Arch Pathol Lab Med | volume = 131 | issue = 8 | pages = 1290-7 | month = Aug | year = 2007 | doi = 10.1043/1543-2165(2007)131[1290:IAOCRC]2.0.CO;2 | PMID = 17683191 }}</ref>/+ve (cytoplasmic). | ||
**[[Chromophobe renal cell carcinoma]] = cell membrane +ve. | **[[Chromophobe renal cell carcinoma]] = cell membrane +ve. | ||
**Based on a mRNA study it was suggested that <50% CK7 immunostaining favours oncocytoma.<ref name=pmid16927643>{{Cite journal | last1 = Adley | first1 = BP. | last2 = Papavero | first2 = V. | last3 = Sugimura | first3 = J. | last4 = Teh | first4 = BT. | last5 = Yang | first5 = XJ. | title = Diagnostic value of cytokeratin 7 and parvalbumin in differentiating chromophobe renal cell carcinoma from renal oncocytoma. | journal = Anal Quant Cytol Histol | volume = 28 | issue = 4 | pages = 228-36 | month = Aug | year = 2006 | doi = | PMID = 16927643 }}</ref> | |||
*PAX8 +ve.<ref name=pmid22135028>{{Cite journal | last1 = Hu | first1 = Y. | last2 = Hartmann | first2 = A. | last3 = Stoehr | first3 = C. | last4 = Zhang | first4 = S. | last5 = Wang | first5 = M. | last6 = Tacha | first6 = D. | last7 = Montironi | first7 = R. | last8 = Lopez-Beltran | first8 = A. | last9 = Cheng | first9 = L. | title = PAX8 is expressed in the majority of renal epithelial neoplasms: an immunohistochemical study of 223 cases using a mouse monoclonal antibody. | journal = J Clin Pathol | volume = 65 | issue = 3 | pages = 254-6 | month = Mar | year = 2012 | doi = 10.1136/jclinpath-2011-200508 | PMID = 22135028 }}</ref> | *PAX8 +ve.<ref name=pmid22135028>{{Cite journal | last1 = Hu | first1 = Y. | last2 = Hartmann | first2 = A. | last3 = Stoehr | first3 = C. | last4 = Zhang | first4 = S. | last5 = Wang | first5 = M. | last6 = Tacha | first6 = D. | last7 = Montironi | first7 = R. | last8 = Lopez-Beltran | first8 = A. | last9 = Cheng | first9 = L. | title = PAX8 is expressed in the majority of renal epithelial neoplasms: an immunohistochemical study of 223 cases using a mouse monoclonal antibody. | journal = J Clin Pathol | volume = 65 | issue = 3 | pages = 254-6 | month = Mar | year = 2012 | doi = 10.1136/jclinpath-2011-200508 | PMID = 22135028 }}</ref> | ||
*[[CD117]] +ve.<ref>{{Cite journal | last1 = Krüger | first1 = S. | last2 = Sotlar | first2 = K. | last3 = Kausch | first3 = I. | last4 = Horny | first4 = HP. | title = Expression of KIT (CD117) in renal cell carcinoma and renal oncocytoma. | journal = Oncology | volume = 68 | issue = 2-3 | pages = 269-75 | month = | year = 2005 | doi = 10.1159/000086783 | PMID = 16015044 }}</ref> | *[[CD117]] +ve.<ref>{{Cite journal | last1 = Krüger | first1 = S. | last2 = Sotlar | first2 = K. | last3 = Kausch | first3 = I. | last4 = Horny | first4 = HP. | title = Expression of KIT (CD117) in renal cell carcinoma and renal oncocytoma. | journal = Oncology | volume = 68 | issue = 2-3 | pages = 269-75 | month = | year = 2005 | doi = 10.1159/000086783 | PMID = 16015044 }}</ref> | ||
**ChRCC also +ve. | **ChRCC also +ve. | ||
*GATA-3 usually -ve (38 cases negative of 47 cases).<ref name=pmid2431520>{{cite journal |authors=Gonzalez-Roibon N, Faraj SF, Munari E, Bezerra SM, Albadine R, Sharma R, Argani P, Allaf ME, Netto GJ |title=Comprehensive profile of GATA binding protein 3 immunohistochemical expression in primary and metastatic renal neoplasms |journal=Hum Pathol |volume=45 |issue=2 |pages=244–8 |date=February 2014 |pmid=24315206 |doi=10.1016/j.humpath.2013.08.020 |url=}}</ref> | |||
**+ve in [[low-grade oncocytic renal tumour]]. | |||
Others: | Others: | ||
| Line 113: | Line 117: | ||
A panel: | A panel: | ||
*CK7, PAX8, CD117, CD10, [[Mueller-Mowry stain]]. | *CK7, PAX8, CD117, CD10, [[Mueller-Mowry stain]], GATA-3. | ||
===Comparison between some renal tumours with eosinophilic cytoplasm=== | |||
{| class="wikitable sortable" | |||
!Tumour | |||
![[CK7]] | |||
![[CD117]] | |||
![[GATA3]] | |||
|- | |||
| Renal oncocytoma | |||
| -ve † | |||
| +ve | |||
| -ve/+ve | |||
|- | |||
| [[Chromophobe renal cell carcinoma]] | |||
| +ve ‡ | |||
| +ve | |||
| -ve | |||
|- | |||
| [[Low-grade oncocytic tumour]] | |||
| +ve | |||
| -ve | |||
| +ve | |||
|- | |||
|} | |||
† may have scattered positive cells<br> | |||
‡ diffuse and strong | |||
==Sign out== | ==Sign out== | ||