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Difference between revisions of "High-grade prostatic intraepithelial neoplasia"
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High-grade prostatic intraepithelial neoplasia (view source)
Revision as of 17:21, 3 April 2024
, 3 Aprilno edit summary
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| Micro = nuclear changes (hyperchromatic nuclei, nucleoli present, +/-increased NC ratio, mild-to-moderate nuclear enlargement), medium-to-large glands with the architecture of HGPIN (tufted, micropapillary, flat) | | Micro = nuclear changes (hyperchromatic nuclei, nucleoli present, +/-increased NC ratio, mild-to-moderate nuclear enlargement), medium-to-large glands with the architecture of HGPIN (tufted, micropapillary, flat) | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = [[basal cell hyperplasia]], [[prostatic adenocarcinoma]], [[PIN-like prostatic ductal adenocarcinoma]], [[atypical small acinar proliferation]] (biopsy only), [[atypical | | LMDDx = [[basal cell hyperplasia]], [[prostatic adenocarcinoma]], [[PIN-like prostatic ductal adenocarcinoma]], [[atypical small acinar proliferation]] (biopsy only), [[atypical intraductal proliferation]] | ||
| Stains = | | Stains = | ||
| IHC = AMACR +ve, basal cells present (p63 +ve, CK34betaE12 +ve) | | IHC = AMACR +ve, basal cells present (p63 +ve, CK34betaE12 +ve) | ||
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*Benign prostate - HGPIN has nuclear changes. | *Benign prostate - HGPIN has nuclear changes. | ||
**Central zone typically has small nucleoli;<ref>{{Cite journal | last1 = Egevad | first1 = L. | title = Cytology of the central zone of the prostate. | journal = Diagn Cytopathol | volume = 28 | issue = 5 | pages = 239-44 | month = May | year = 2003 | doi = 10.1002/dc.10275 | PMID = 12722118 }}</ref> however, the glands are larger. | **Central zone typically has small nucleoli;<ref>{{Cite journal | last1 = Egevad | first1 = L. | title = Cytology of the central zone of the prostate. | journal = Diagn Cytopathol | volume = 28 | issue = 5 | pages = 239-44 | month = May | year = 2003 | doi = 10.1002/dc.10275 | PMID = 12722118 }}</ref> however, the glands are larger. | ||
*[[Atypical intraductal proliferation]] - a [[waffle diagnosis]] when criteria insufficient for [[intraductal carcinoma of the prostate]]. | |||
===HGPIN architecture=== | ===HGPIN architecture=== | ||